Summary: COMPASS (Complex proteins associated with Set1p) component N
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The n-SET or N-SET domain is a component of the COMPASS complex, associated with SET1, conserved in yeasts and in other eukaryotes up to humans. The COMPASS complex functions to methylate the fourth lysine of Histone 3 and for the silencing of genes close to the telomeres of chromosomes . This domain promotes trimethylation in conjunction with an RRM domain  and is necessary for binding of the Spp1 component of COMPASS into the complex .
Roguev A, Schaft D, Shevchenko A, Pijnappel WW, Wilm M, Aasland R, Stewart AF; , EMBO J 2001;20:7137-7148.: The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4. PUBMED:11742990 EPMC:11742990
Krogan NJ, Dover J, Khorrami S, Greenblatt JF, Schneider J, Johnston M, Shilatifard A; , J Biol Chem. 2002;277:10753-10755.: COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression. PUBMED:11805083 EPMC:11805083
Dehe PM, Dichtl B, Schaft D, Roguev A, Pamblanco M, Lebrun R, Rodriguez-Gil A, Mkandawire M, Landsberg K, Shevchenko A, Shevchenko A, Rosaleny LE, Tordera V, Chavez S, Stewart AF, Geli V; , J Biol Chem. 2006;281:35404-35412.: Protein interactions within the Set1 complex and their roles in the regulation of histone 3 lysine 4 methylation. PUBMED:16921172 EPMC:16921172
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR024657
The COMPASS complex (complex proteins associated with Set1p) is conserved in yeasts and in other eukaryotes up to humans. The COMPASS complex functions to methylate the fourth lysine of Histone 3 and for the silencing of genes close to the telomeres of chromosomes [PUBMED:11805083].
Five domains are conserved in Saccharomyces cerevisiae Set1 and other eukaryotic Set1-related proteins: an amino-terminal RNA-recognition motif (RRM), a semi-conserved central domain, an N-SET domain, the catalytic SET domain, and the C-terminal post-SET domain. This entry represents the N-SET domain, which promotes trimethylation in conjunction with the RRM domain [PUBMED:15775977] and is necessary for binding of the Spp1 component of COMPASS into the complex [PUBMED:16921172].
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Curation and family details
|Seed source:||Pfam-B_7375 (release 23.0)|
|Number in seed:||31|
|Number in full:||286|
|Average length of the domain:||151.20 aa|
|Average identity of full alignment:||32 %|
|Average coverage of the sequence by the domain:||11.68 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||3|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the N-SET domain has been found. There are 5 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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