Summary: Myogenic determination factor 5
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Myogenic determination factor 5 Edit Wikipedia article
|crystal structure of myod bhlh domain bound to dna: perspectives on dna recognition and implications for transcriptional activation|
In molecular biology, the myogenic determination factor 5 proteins are a family of proteins found in eukaryotes. This family includes the Myf5 protein, which is responsible for directing cells to the skeletal myocyte lineage during development. Myf5 is likely to act in a similar way to the other MRF4 proteins such as MyoD which perform the same function. These are histone acetyltransferases and histone deacetylases which activate and repress genes involved in the myocyte lineage.
Myogenic determination factor 5 proteins contain three conserved protein domains. A C-terminal Myf5 domain, a central basic helix-loop-helix (bHLH) domain and an N-terminal basic domain. The bHLH region mediates specific DNA binding. With 12 residues of the basic domain involved in DNA binding. The basic domain forms an extended alpha helix in the structure.
- ^ Hamamori Y, Wu HY, Sartorelli V, Kedes L (November 1997). "The basic domain of myogenic basic helix-loop-helix (bHLH) proteins is the novel target for direct inhibition by another bHLH protein, Twist". Mol. Cell. Biol. 17 (11): 6563â73. PMC 232510. PMID 9343420. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=232510.
- ^ Molkentin JD, Olson EN (September 1996). "Combinatorial control of muscle development by basic helix-loop-helix and MADS-box transcription factors". Proc. Natl. Acad. Sci. U.S.A. 93 (18): 9366â73. doi:10.1073/pnas.93.18.9366. PMC 38433. PMID 8790335. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=38433.
Myogenic determination factor 5 Provide feedback
This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The family is found in association with PF00010 PF01586. There is a conserved CSD sequence motif. Myf5 is responsible for directing cells to the skeletal myocyte lineage during development. Myf5 is likely to act in a similar way to the other MRF4 proteins such as MyoD which perform the same function. These are histone acetyltransferases and histone deacetylases which activate and repress genes involved in the myocyte lineage.
Ye HQ, Chen SL, Xu JY;, Comp Biochem Physiol B Biochem Mol Biol. 2007;147:452-459.: Molecular cloning and characterization of the Myf5 gene in sea perch (Lateolabrax japonicus). PUBMED:17395511 EPMC:17395511
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR022032
This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The family is found in association with , . There is a conserved CSD sequence motif. Myf5 is responsible for directing cells to the skeletal myocyte lineage during development. Myf5 is likely to act in a similar way to the other MRF4 proteins such as MyoD which perform the same function. These are histone acetyltransferases and histone deacetylases which activate and repress genes involved in the myocyte lineage.
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Curation and family details
|Seed source:||PFAM-B_2654 (release 23.0)|
|Number in seed:||28|
|Number in full:||259|
|Average length of the domain:||63.60 aa|
|Average identity of full alignment:||47 %|
|Average coverage of the sequence by the domain:||25.66 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||3|
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