Summary: RNAPII transcription regulator C-terminal
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RNAPII transcription regulator C-terminal Provide feedback
MMS19 is required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription . This C-terminal domain, along with the N-terminal, MMS19_N, form part of a silencing complex in fission yeast that contains Dos2, Rik1, Mms19 and Cdc20 (the catalytic subunit of DNA polymerase-epsilon). This complex regulates RNA polymerase II (RNA Pol II) activity in heterochromatin and is required for DNA replication and heterochromatin assembly . This domain apparently shares homology with some HEAT repeat sequences.
Queimado L, Rao M, Schultz RA, Koonin EV, Aravind L, Nardo T, Stefanini M, Friedberg EC;, Nucleic Acids Res. 2001;29:1884-1891.: Cloning the human and mouse MMS19 genes and functional complementation of a yeast mms19 deletion mutant. PUBMED:11328871 EPMC:11328871
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This tab holds annotation information from the InterPro database.
InterPro entry IPR024687
This domain, approximately 60 amino acids in length, is found in the N-terminal region of MMS19 proteins. MMS19 is required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription [PUBMED:11328871].
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Curation and family details
|Author:||Gavin OL, Coggill P|
|Number in seed:||60|
|Number in full:||284|
|Average length of the domain:||381.10 aa|
|Average identity of full alignment:||21 %|
|Average coverage of the sequence by the domain:||40.43 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||3|
|Download:||download the raw HMM for this family|
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