Summary: Capicua transcriptional repressor modulator
Capicua transcriptional repressor modulator Provide feedback
This family of proteins is found in eukaryotes. Proteins in this family are typically between 49 and 781 amino acids in length. There is a conserved IQT sequence motif. ATXN1 directly binds Capicua and modulates Capicua repressor activity in Drosophila and mammalian cells. The polyglutamine expanded mutant type of ATXN-1 does not bind Capicua with as high affinity as wild-type ATXN-1. It is associated with spinocerebellar ataxia type 1 (SCA1).
Lam YC, Bowman AB, Jafar-Nejad P, Lim J, Richman R, Fryer JD, Hyun ED, Duvick LA, Orr HT, Botas J, Zoghbi HY;, Cell. 2006;127:1335-1347.: ATAXIN-1 interacts with the repressor Capicua in its native complex to cause SCA1 neuropathology. PUBMED:17190598 EPMC:17190598
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This tab holds annotation information from the InterPro database.
InterPro entry IPR020997
This entry represents Capicua transcriptional repressor modulator Ataxin-1, which directly binds Capicua and modulates Capicua repressor activity in Drosophila and mammalian cells. It is also thought to be involved in RNA metabolism and the expansion of the polyglutamine tract may alter this function.
Ataxin-1 is typically between 49 and 781 amino acids in length and have a conserved IQT sequence motif. The polyglutamine expanded mutant type of Ataxin-1 does not bind Capicua with as high affinity as wild-type Ataxin-1. It is associated with spinocerebellar ataxia type 1 (SCA1) [PUBMED:17190598].
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|Number in seed:||5|
|Number in full:||77|
|Average length of the domain:||39.00 aa|
|Average identity of full alignment:||78 %|
|Average coverage of the sequence by the domain:||8.02 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||3|
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