Summary: Transcriptional regulator of RNA polII, SAGA, subunit
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Transcriptional regulator of RNA polII, SAGA, subunit Provide feedback
The yeast SAGA complex is a multifunctional coactivator that regulates transcription by RNA polymerase II [1,2]. It is formed of five major modular subunits and shows a high degree of structural conservation to human TFTC and STAGA . The complex can also be conceived of as consisting of two histone-fold-containing core subunits, and this family is one of these. As a family it is likely to carry binding regions for interactions with a number of the other components of the complex.
Koltovaya NA, Guerasimova AS, Tchekhouta IA, Devin AB;, Yeast. 2003;20:955-971.: NET1 and HFI1 genes of yeast mediate both chromosome maintenance and mitochondrial rho(-) mutagenesis. PUBMED:12898711 EPMC:12898711
Martinez E, Palhan VB, Tjernberg A, Lymar ES, Gamper AM, Kundu TK, Chait BT, Roeder RG;, Mol Cell Biol. 2001;21:6782-6795.: Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo. PUBMED:11564863 EPMC:11564863
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR024738
The yeast Spt-Ada-Gcn5-Acetyl (SAGA) transferase complex is a multifunctional coactivator involved in multiple cellular processes [PUBMED:17694076], including regulation of transcription by RNA polymerase II [PUBMED:12898711, PUBMED:15260971]. It is formed of five major modular subunits and shows a high degree of structural conservation to human TFTC and STAGA [PUBMED:11564863]. This entry represents Ada1 (known as Tada1 in higher eukaryotes), one of the subunits that constitute the SAGA core. It also functions as a component of the SALSA and SLIK complexes.
|Cellular component||SAGA-type complex (GO:0070461)|
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|Seed source:||Pfam-B_319 (release 24.0)|
|Author:||Wood V, Coggill P|
|Number in seed:||65|
|Number in full:||356|
|Average length of the domain:||212.60 aa|
|Average identity of full alignment:||22 %|
|Average coverage of the sequence by the domain:||55.99 %|
|HMM build commands:||
build method: hmmbuild --amino -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||2|
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