Summary: Extended Signal Peptide of Type V secretion system
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Extended Signal Peptide of Type V secretion system Provide feedback
This conserved domain is called ESPR for Extended Signal Peptide Region. It is present at the N-terminus of the signal peptides of proteins belonging to the Type V secretion systems, including the autotransporters (T5aSS), TpsA exoproteins of the two-partner system (T5bSS) and trimeric autotransporters (TAAs). So far, the ESPR is present only in Gram-negative bacterial proteins originating from the classes Beta- and Gamma-proteobacteria. ESPR severely impairs inner membrane translocation, suggesting that it adopts a particular conformation or it interacts with a cytoplasmic or inner membrane co-factor, prior to exportation. Deletion of ESPR causes mis-folding of the TAAs passenger domain in the periplasm , substantially impairing its translocation across the outer membrane .
Desvaux M, Cooper LM, Filenko NA, Scott-Tucker A, Turner SM, Cole JA, Henderson IR;, FEMS Microbiol Lett. 2006;264:22-30.: The unusual extended signal peptide region of the type V secretion system is phylogenetically restricted. PUBMED:17020545 EPMC:17020545
Desvaux M, Scott-Tucker A, Turner SM, Cooper LM, Huber D, Nataro JP, Henderson IR;, Microbiology. 2007;153:59-70.: A conserved extended signal peptide region directs posttranslational protein translocation via a novel mechanism. PUBMED:17185535 EPMC:17185535
Leyton DL, Rossiter AE, Henderson IR;, Nat Rev Microbiol. 2012;10:213-225.: From self sufficiency to dependence: mechanisms and factors important for autotransporter biogenesis. PUBMED:22337167 EPMC:22337167
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This tab holds annotation information from the InterPro database.
InterPro entry IPR024973
The extended signal peptide region (ESPR) is a highly conserved region found at the N terminus of the signal peptides of proteins belonging to the Type V secretion systems [PUBMED:17020545, PUBMED:17185535]. These proteins include the autotransporters (T5aSS), TpsA exoproteins of the two-partner system (T5bSS) and trimeric autotransporters (T5cSS). ESPR severely impairs inner membrane translocation, suggesting that it adopts a particular conformation or it interacts with a cytoplasmic or inner membrane co-factor, prior to exportation.
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Curation and family details
|Seed source:||Desvaux M|
|Author:||Coggill P, Desvaux M|
|Number in seed:||290|
|Number in full:||2495|
|Average length of the domain:||24.40 aa|
|Average identity of full alignment:||44 %|
|Average coverage of the sequence by the domain:||1.62 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||1|
|Download:||download the raw HMM for this family|
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