Summary: Biotin-lipoyl like
This is the Wikipedia entry entitled "Biotin attachment domain". More...
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Biotin attachment domain Edit Wikipedia article
Biotin/lipoyl attachment domain has a conserved lysine residue that binds biotin or lipoic acid. Biotin plays a catalytic role in some carboxyl transfer reactions and is covalently attached, via an amide bond, to a lysine residue in enzymes requiring this coenzyme. Lipoamide acyltransferases have an essential cofactor, lipoic acid, which is covalently bound via an amide linkage to a lysine group. The lipoic acid cofactor is found in a variety of proteins.
 Human proteins containing this domain
- Kumar GK, Shenoy BC, Wood HG, Samols D, Xie Y, Park VL, Beegen H (1992). "The importance of methionine residues for the catalysis of the biotin enzyme, transcarboxylase. Analysis by site-directed mutagenesis". J. Biol. Chem. 267 (26): 18407–18412. PMID 1526981.
- Guest JR, Russell GC (1991). "Sequence similarities within the family of dihydrolipoamide acyltransferases and discovery of a previously unidentified fungal enzyme". Biochim. Biophys. Acta 1076 (2): 225–232. PMID 1825611.
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Biotin-lipoyl like Provide feedback
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Internal database links
|Similarity to PfamA using HHSearch:||QRPTase_N Biotin_lipoyl Biotin_lipoyl HlyD PTS_EIIA_1 NQRA PYNP_C HlyD_2 HlyD_3|
External database links
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This superfamily contains proteins with a hybrid motif . This motif is embedded in structurally diverse proteins.
The clan contains the following 17 members:Apocytochr_F_C Biotin_lipoyl Biotin_lipoyl_2 Complex1_51K DUF2118 DUF2254 GCV_H HlyD HlyD_2 HlyD_3 NQRA OEP Peptidase_M23 PTS_EIIA_1 PYNP_C QRPTase_N RnfC_N
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Curation and family details
|Number in seed:||99|
|Number in full:||2242|
|Average length of the domain:||54.60 aa|
|Average identity of full alignment:||29 %|
|Average coverage of the sequence by the domain:||15.15 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||1|
|Download:||download the raw HMM for this family|
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