Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
0  structures 298  species 0  interactions 360  sequences 3  architectures

Family: BCIP (PF13862)

Summary: p21-C-terminal region-binding protein

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

p21-C-terminal region-binding protein Provide feedback

This family of p21-binding proteins is important as a modulator of p21 activity. The domain binds the C-terminal region of p21 in a ternary complex with CDK2, which results in inhibition of the kinase activity of CDK2.

Literature references

  1. Ono T, Kitaura H, Ugai H, Murata T, Yokoyama KK, Iguchi-Ariga SM, Ariga H;, J Biol Chem. 2000;275:31145-31154.: TOK-1, a novel p21Cip1-binding protein that cooperatively enhances p21-dependent inhibitory activity toward CDK2 kinase. PUBMED:10878006 EPMC:10878006

  2. Meng X, Liu J, Shen Z;, Gene. 2003;302:139-146.: Genomic structure of the human BCCIP gene and its expression in cancer. PUBMED:12527204 EPMC:12527204

  3. Lu H, Yue J, Meng X, Nickoloff JA, Shen Z;, Nucleic Acids Res. 2007;35:7160-7170.: BCCIP regulates homologous recombination by distinct domains and suppresses spontaneous DNA damage. PUBMED:17947333 EPMC:17947333

  4. Ash SC, Yang DQ, Britt DE;, Biochem Biophys Res Commun. 2008;371:333-338.: LYRIC/AEG-1 overexpression modulates BCCIPalpha protein levels in prostate tumor cells. PUBMED:18440304 EPMC:18440304


External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR025602

This family of proteins includes BRCA2 and CDKN1A-interacting protein (BCCIP), which may promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A/p21 [PUBMED:10878006]. The family also includes the related protein Bcp1, which is Involved in nuclear export of the lipid kinase MSS4 and of the 60S ribosomal subunit in yeast [PUBMED:12912920].

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

Loading domain graphics...

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database using the family HMM. We also generate alignments using four representative proteomes (RP) sets, the NCBI sequence database, and our metagenomics sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(87)
Full
(360)
Representative proteomes NCBI
(367)
Meta
(11)
RP15
(82)
RP35
(134)
RP55
(194)
RP75
(238)
Jalview View  View  View  View  View  View  View  View 
HTML View  View  View  View  View  View     
PP/heatmap 1 View  View  View  View  View     
Pfam viewer View  View             

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(87)
Full
(360)
Representative proteomes NCBI
(367)
Meta
(11)
RP15
(82)
RP35
(134)
RP55
(194)
RP75
(238)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(87)
Full
(360)
Representative proteomes NCBI
(367)
Meta
(11)
RP15
(82)
RP35
(134)
RP55
(194)
RP75
(238)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

External links

MyHits provides a collection of tools to handle multiple sequence alignments. For example, one can refine a seed alignment (sequence addition or removal, re-alignment or manual edition) and then search databases for remote homologs using HMMER3.

Pfam alignments:

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Jackhmmer:Q9P287
Previous IDs: none
Type: Family
Author: Coggill P
Number in seed: 87
Number in full: 360
Average length of the domain: 198.30 aa
Average identity of full alignment: 28 %
Average coverage of the sequence by the domain: 65.46 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 20.7 20.7
Trusted cut-off 21.5 25.5
Noise cut-off 20.4 19.5
Model length: 194
Family (HMM) version: 1
Download: download the raw HMM for this family

Species distribution

Sunburst controls

Show

This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

Loading sunburst data...

Tree controls

Hide

The tree shows the occurrence of this domain across different species. More...

Loading...

Please note: for large trees this can take some time. While the tree is loading, you can safely switch away from this tab but if you browse away from the family page entirely, the tree will not be loaded.