Summary: Pab87 octamerisation domain
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Pab87 octamerisation domain Provide feedback
This domain was first characterised as the C-terminal domain of Pab87 serine protease from Pyrococcus abyssi . The domain is reported to play a crucial role in Pab87 octamerisation and active site compartmentalisation. Its up-and-down 8-stranded beta-barrel 3D structure is reminiscent of the one found in lipocalins.
Delfosse V, Girard E, Birck C, Delmarcelle M, Delarue M, Poch O, Schultz P, Mayer C;, PLoS One. 2009;4:e4712.: Structure of the archaeal pab87 peptidase reveals a novel self-compartmentalizing protease family. PUBMED:19266066 EPMC:19266066
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR025879
This domain was first characterised as the C-terminal domain of Pab87 serine protease from Pyrococcus abyssi [PUBMED:19266066]. The domain is reported to play a crucial role in Pab87 octamerisation and active site compartmentalisation. Its up-and-down 8-stranded beta-barrel 3D structure is reminiscent of the one found in lipocalins.
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This example describes an architecture with one
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1Cannot generate PP/Heatmap alignments for seeds; no PP data available
Key: available, not generated, — not available.
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Curation and family details
|Number in seed:||6|
|Number in full:||15|
|Average length of the domain:||95.70 aa|
|Average identity of full alignment:||34 %|
|Average coverage of the sequence by the domain:||22.07 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||1|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Pab87_oct domain has been found. There are 8 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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