Summary: Mrr N-terminal domain
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Mrr N-terminal domain Provide feedback
This domain is found at the N-terminus of the Mrr restriction endonuclease catalytic domain, PF04471 [1,2]. Fold recognition analysis predicts that it is a diverged member of the winged helix variant of helix turn helix proteins. It may play a role in DNA sequence recognition .
Bujnicki JM, Rychlewski L; , Gene 2001;267:183-191.: Identification of a PD-(D/E)XK-like domain with a novel configuration of the endonuclease active site in the methyl-directed restriction enzyme Mrr and its homologs. PUBMED:11313145 EPMC:11313145
Orlowski J, Mebrhatu MT, Michiels CW, Bujnicki JM, Aertsen A;, Biochem Biophys Res Commun. 2008;377:862-866.: Mutational analysis and a structural model of methyl-directed restriction enzyme Mrr. PUBMED:18951880 EPMC:18951880
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR025745
This domain is found N-terminal to the catalytic domain in Mrr restriction endonucleases [PUBMED:11313145, PUBMED:18951880]. It is also found in other proteins, including predicted methyltransferases and ATPases. Fold recognition analysis predicts that it is a diverged member of the winged helix variant of helix turn helix proteins. It may play a role in DNA sequence recognition [PUBMED:18951880].
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Curation and family details
|Number in seed:||132|
|Number in full:||557|
|Average length of the domain:||89.00 aa|
|Average identity of full alignment:||25 %|
|Average coverage of the sequence by the domain:||28.56 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||1|
|Download:||download the raw HMM for this family|
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