Summary: TMEM192 family
TMEM192 family Provide feedback
The function of this family of transmembrane proteins is unknown. In vertebrates, proteins in this family are located in the lysosomal membrane and late endosome [1-2]. In Arabidopsis, a member of this family has been found to weakly interact with FRIGIDA, a determinant of flowering time .
Schroder B, Wrocklage C, Hasilik A, Saftig P;, Biol Chem. 2010;391:695-704.: Molecular characterisation of 'transmembrane protein 192' (TMEM192), a novel protein of the lysosomal membrane. PUBMED:20370317 EPMC:20370317
Behnke J, Eskelinen EL, Saftig P, Schroder B;, Biochem J. 2011;434:219-231.: Two dileucine motifs mediate late endosomal/lysosomal targeting of transmembrane protein 192 (TMEM192) and a C-terminal cysteine residue is responsible for disulfide bond formation in TMEM192 homodimers. PUBMED:21143193 EPMC:21143193
Geraldo N, Baurle I, Kidou S, Hu X, Dean C;, Plant Physiol. 2009;150:1611-1618.: FRIGIDA delays flowering in Arabidopsis via a cotranscriptional mechanism involving direct interaction with the nuclear cap-binding complex. PUBMED:19429606 EPMC:19429606
External database links
This tab holds annotation information from the InterPro database.
No InterPro data for this Pfam family.
- the number of sequences which exhibit this architecture
a textual description of the architecture, e.g. Gla, EGF x 2, Trypsin.
This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
- the UniProt description of the protein sequence
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We make a range of alignments for each Pfam-A family:
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Curation and family details
This family is new in this Pfam release.
|Number in seed:||19|
|Number in full:||137|
|Average length of the domain:||206.00 aa|
|Average identity of full alignment:||32 %|
|Average coverage of the sequence by the domain:||76.71 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||1|
|Download:||download the raw HMM for this family|
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