Summary: Death-like domain of SPT6
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Death-like domain of SPT6 Provide feedback
This DLD domain maintains the characteristic overall topology of death domains, as it consists of a six-helix bundle with three stacked antiparallel helices and an additional helix inserted between the final two helices of the bundle. Although it is unlikely that the Spt6 DLD functions in an apoptotic process in yeast, its prominent location and the observation that it displays the most highly conserved region of the Spt6 surface suggest that it mediates important intermolecular interactions [1,2].
McDonald SM, Close D, Xin H, Formosa T, Hill CP;, Mol Cell. 2010;40:725-735.: Structure and biological importance of the Spn1-Spt6 interaction, and its regulatory role in nucleosome binding. PUBMED:21094070 EPMC:21094070
Kiely CM, Marguerat S, Garcia JF, Madhani HD, Bahler J, Winston F;, Mol Cell Biol. 2011;31:4193-4204.: Spt6 is required for heterochromatic silencing in the fission yeast Schizosaccharomyces pombe. PUBMED:21844224 EPMC:21844224
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Curation and family details
This family is new in this Pfam release.
|Seed source:||Pfam-B_9510 (release 26.0)|
|Author:||Wood V, Coggill P|
|Number in seed:||4|
|Number in full:||271|
|Average length of the domain:||113.10 aa|
|Average identity of full alignment:||46 %|
|Average coverage of the sequence by the domain:||7.70 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||1|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the DLD domain has been found. There are 2 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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