Summary: Type I membrane glycoproteins cell-cell fusogen
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Type I membrane glycoproteins cell-cell fusogen Provide feedback
EFF-AFF was first identified when EFF1 mutants were found to block cell fusion in all epidermal and vulval epithelia in the worm . However, fusion between the anchor cell and the utse syncytium that establishes a continuous uterine-vulval tube proceeds normally in eff-1 mutants and thus Aff1 was established as necessary for this and the fusion of heterologous cells in C. elegans . The transmembrane forms of FF proteins, like most viral fusogens, possess an N-terminal signal sequence followed by a long extracellular portion, a predicted transmembrane domain, and a short intracellular tail. A striking conservation in the position and number of all 16 cysteines in the extracellular portion of FF proteins from different nematode species suggests that these proteins are folded in a similar 3D structure that is essential for their fusogenic activity . C. elegans AFF-1 and EFF-1 proteins are essential for developmental cell-to-cell fusion and can merge insect cells. Thus FFs comprise an ancient family of cellular fusogens that can promote fusion when expressed on a viral particle .
Mohler WA, Shemer G, del Campo JJ, Valansi C, Opoku-Serebuoh E, Scranton V, Assaf N, White JG, Podbilewicz B;, Dev Cell. 2002;2:355-362.: The type I membrane protein EFF-1 is essential for developmental cell fusion. PUBMED:11879640 EPMC:11879640
Sapir A, Choi J, Leikina E, Avinoam O, Valansi C, Chernomordik LV, Newman AP, Podbilewicz B;, Dev Cell. 2007;12:683-698.: AFF-1, a FOS-1-regulated fusogen, mediates fusion of the anchor cell in C. elegans. PUBMED:17488621 EPMC:17488621
Avinoam O, Fridman K, Valansi C, Abutbul I, Zeev-Ben-Mordehai T, Maurer UE, Sapir A, Danino D, Grunewald K, White JM, Podbilewicz B;, Science. 2011;332:589-592.: Conserved eukaryotic fusogens can fuse viral envelopes to cells. PUBMED:21436398 EPMC:21436398
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This tab holds annotation information from the InterPro database.
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This family is new in this Pfam release.
|Seed source:||Podbilewicz B, , Pfam-B_25631 (release 26.0)|
|Author:||Podbilewicz B, Coggill P|
|Number in seed:||4|
|Number in full:||33|
|Average length of the domain:||393.20 aa|
|Average identity of full alignment:||31 %|
|Average coverage of the sequence by the domain:||92.34 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||1|
|Download:||download the raw HMM for this family|
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