Summary: EmbC C-terminal domain
This is the Wikipedia entry entitled "Arabinosyltransferase". More...
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Arabinosyltransferase Edit Wikipedia article
In molecular biology, an arabinosyltransferase is a transferase enzyme acting upon arabinose. This enzyme is involved in polymerisation of arabinogalactan (an essential component of the mycobacterial cell wall). In terms of mycobacteria, the more precise term is arabinofuranosyltransferase, since the arabinose residues occur only in a furanose form.
- Belanger AE, Besra GS, Ford ME, Mikusova K, Belisle JT, Brennan PJ, Inamine JM (October 1996). "The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol". Proc. Natl. Acad. Sci. U.S.A. 93 (21): 11919–24. doi:10.1073/pnas.93.21.11919. PMC 38159. PMID 8876238.
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EmbC C-terminal domain Provide feedback
Arabinosyltransferase is involved in arabinogalactan (AG) biosynthesis pathway in mycobacteria. AG is a component of the macromolecular assembly of the mycolyl-AG-peptidoglycan complex of the cell wall. This enzyme has important clinical applications as it is believed to be the target of the antimycobacterial drug Ethambutol . This domain represents the C-terminal extracellular domain that is likely to bind to carbohydrate .
Belanger AE, Besra GS, Ford ME, Mikusova K, Belisle JT, Brennan PJ, Inamine JM; , Proc Natl Acad Sci U S A 1996;93:11919-11924.: The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol. PUBMED:8876238 EPMC:8876238
Alderwick LJ, Lloyd GS, Ghadbane H, May JW, Bhatt A, Eggeling L, Futterer K, Besra GS;, PLoS Pathog. 2011;7:e1001299.: The C-terminal domain of the Arabinosyltransferase Mycobacterium tuberculosis EmbC is a lectin-like carbohydrate binding module. PUBMED:21383969 EPMC:21383969
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This tab holds annotation information from the InterPro database.
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We make a range of alignments for each Pfam-A family:
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Curation and family details
This family is new in this Pfam release.
|Seed source:||Pfam-B_4670 (release 7.5)|
|Number in seed:||7|
|Number in full:||454|
|Average length of the domain:||346.80 aa|
|Average identity of full alignment:||41 %|
|Average coverage of the sequence by the domain:||34.95 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||1|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Arabino_trans_C domain has been found. There are 1 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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