Summary: Testicular haploid expressed repeat
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Testicular haploid expressed repeat Provide feedback
This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions [1,2]. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice .
Nayernia K, von Mering MH, Kraszucka K, Burfeind P, Wehrend A, Kohler M, Schmid M, Engel W;, Biol Reprod. 1999;60:1488-1495.: A novel testicular haploid expressed gene (THEG) involved in mouse spermatid-sertoli cell interaction. PUBMED:10330110 EPMC:10330110
Mannan A, Lucke K, Dixkens C, Neesen J, Kamper M, Engel W, Burfeind P;, Cytogenet Cell Genet. 2000;91:171-179.: Alternative splicing, chromosome assignment and subcellular localization of the testicular haploid expressed gene (THEG). PUBMED:11173852 EPMC:11173852
Mannan AU, Nayernia K, Mueller C, Burfeind P, Adham IM, Engel W;, Biol Reprod. 2003;69:788-796.: Male mice lacking the Theg (testicular haploid expressed gene) protein undergo normal spermatogenesis and are fertile. PUBMED:12748127 EPMC:12748127
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This family is new in this Pfam release.
|Number in seed:||37|
|Number in full:||329|
|Average length of the domain:||51.20 aa|
|Average identity of full alignment:||24 %|
|Average coverage of the sequence by the domain:||50.06 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||1|
|Download:||download the raw HMM for this family|
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