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4  structures 13  species 0  interactions 17  sequences 2  architectures

Family: PMAIP1 (PF15150)

Summary: Phorbol-12-myristate-13-acetate-induced

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This is the Wikipedia entry entitled "Phorbol-12-myristate-13-acetate-induced protein 1". More...

Phorbol-12-myristate-13-acetate-induced protein 1 Edit Wikipedia article

Phorbol-12-myristate-13-acetate-induced protein 1
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM604959 HomoloGene88883 GeneCards: PMAIP1 Gene
RNA expression pattern
PBB GE PMAIP1 204286 s at tn.png
PBB GE PMAIP1 204285 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5366 n/a
Ensembl ENSG00000141682 n/a
UniProt Q13794 n/a
RefSeq (mRNA) NM_021127 n/a
RefSeq (protein) NP_066950 n/a
Location (UCSC) Chr 18:
57.57 – 57.57 Mb
PubMed search [1] n/a

Phorbol-12-myristate-13-acetate-induced protein 1 is a protein that in humans is encoded by the PMAIP1 gene, and is also known as Noxa.[1][2][3]

Noxa (Latin for damage) is a pro-apoptotic member of the Bcl-2 protein family.[4] Bcl-2 family members can form hetero- or homodimers, and they act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The expression of Noxa is regulated by the tumor suppressor p53, and Noxa has been shown to be involved in p53-mediated apoptosis.


Noxa has been shown to interact with MCL1,[5][6] BCL2-like 1[5][7] and Bcl-2.[5][7]

See also[edit]


  1. ^ Hijikata M, Kato N, Sato T, Kagami Y, Shimotohno K (October 1990). "Molecular cloning and characterization of a cDNA for a novel phorbol-12-myristate-13-acetate-responsive gene that is highly expressed in an adult T-cell leukemia cell line". J Virol 64 (10): 4632–9. PMC 247947. PMID 2398525. 
  2. ^ Jansson AK, Emterling AM, Arbman G, Sun XF (July 2003). "Noxa in colorectal cancer: a study on DNA, mRNA and protein expression". Oncogene 22 (30): 4675–8. doi:10.1038/sj.onc.1206655. PMID 12879012. 
  3. ^ "Entrez Gene: PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1". 
  4. ^ Oda, E.; Ohki R., Murasawa H., Nemoto J., Shibue T., Yamashita T., Tokino T., Taniguchi T. and Tanaka N. (May 2000). "Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis". Science 288 (5468): 1053–1058. doi:10.1126/science.288.5468.1053. PMID 10807576. 
  5. ^ a b c Chen, Lin; Willis Simon N, Wei Andrew, Smith Brian J, Fletcher Jamie I, Hinds Mark G, Colman Peter M, Day Catherine L, Adams Jerry M, Huang David C S (February 2005). "Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function". Mol. Cell (United States) 17 (3): 393–403. doi:10.1016/j.molcel.2004.12.030. ISSN 1097-2765. PMID 15694340. 
  6. ^ Willis, Simon N; Chen Lin, Dewson Grant, Wei Andrew, Naik Edwina, Fletcher Jamie I, Adams Jerry M, Huang David C S (June 2005). "Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins". Genes Dev. (United States) 19 (11): 1294–305. doi:10.1101/gad.1304105. ISSN 0890-9369. PMC 1142553. PMID 15901672. 
  7. ^ a b Oda, E; Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N (May 2000). "Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis". Science (UNITED STATES) 288 (5468): 1053–8. doi:10.1126/science.288.5468.1053. ISSN 0036-8075. PMID 10807576. 

Further reading[edit]

External links[edit]

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Phorbol-12-myristate-13-acetate-induced Provide feedback

This family carries a BH3 domain between residues 23 and 40.

Literature references

  1. Kelekar A, Thompson CB;, Trends Cell Biol. 1998;8:324-330.: Bcl-2-family proteins: the role of the BH3 domain in apoptosis. PUBMED:9704409 EPMC:9704409

  2. Lutz RJ;, Biochem Soc Trans. 2000;28:51-56.: Role of the BH3 (Bcl-2 homology 3) domain in the regulation of apoptosis and Bcl-2-related proteins. PUBMED:10816098 EPMC:10816098

External database links

This tab holds annotation information from the InterPro database.

No InterPro data for this Pfam family.

Domain organisation

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We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database using the family HMM. We also generate alignments using four representative proteomes (RP) sets, the NCBI sequence database, and our metagenomics sequence database. More...

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You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

External links

MyHits provides a collection of tools to handle multiple sequence alignments. For example, one can refine a seed alignment (sequence addition or removal, re-alignment or manual edition) and then search databases for remote homologs using HMMER3.

Pfam alignments:

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HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...


This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

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Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

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This family is new in this Pfam release.

Seed source: Jackhmmer:Q13794
Previous IDs: none
Type: Family
Author: Eberhardt RY, Coggill P, Hetherington K
Number in seed: 3
Number in full: 17
Average length of the domain: 50.50 aa
Average identity of full alignment: 67 %
Average coverage of the sequence by the domain: 80.49 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 27.0 27.0
Trusted cut-off 27.5 33.8
Noise cut-off 25.1 24.3
Model length: 54
Family (HMM) version: 1
Download: download the raw HMM for this family

Species distribution

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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the PMAIP1 domain has been found. There are 4 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.

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