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0  structures 39  species 0  interactions 215  sequences 6  architectures

Family: CEP170_C (PF15308)

Summary: CEP170 C-terminus

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This is the Wikipedia entry entitled "CEP170". More...

CEP170 Edit Wikipedia article

Centrosomal protein 170kDa
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CEP170; FAM68A; KAB; KIAA0470
External IDs OMIM613023 MGI1918348 HomoloGene22844 GeneCards: CEP170 Gene
Orthologs
Species Human Mouse
Entrez 9859 545389
Ensembl ENSG00000143702 ENSMUSG00000057335
UniProt Q5SW79 Q6A065
RefSeq (mRNA) NM_001042404 NM_001024722
RefSeq (protein) NP_001035863 NP_001093107
Location (UCSC) Chr 1:
243.29 – 243.42 Mb
Chr 1:
176.73 – 176.81 Mb
PubMed search [1] [2]

Centrosomal protein 170kDa, also known as CEP170, is a protein that in humans is encoded by the CEP170 gene.[1][2]

Function[edit]

The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with the intraflagellar transport protein 81 (IFT81), the SH3-domain containing protein PRAX-1, and is phosphorylated by cyclin dependent kinase 1 ( Cdk1 ) and polo-like kinase 1 ( PLK1 ), and functions in maintaining Microtubule organization, cell morphology and cilium stability.[1]

The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined.[1]

References[edit]

  1. ^ a b c "Entrez Gene: CEP170 centrosomal protein 170kDa". 
  2. ^ Guarguaglini G, Duncan PI, Stierhof YD, Holmström T, Duensing S, Nigg EA (March 2005). "The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles". Molecular Biology of the Cell 16 (3): 1095–107. doi:10.1091/mbc.E04-10-0939. PMC 551476. PMID 15616186. 

Further reading[edit]


This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

CEP170 C-terminus Provide feedback

This family includes the C-terminus of centrosomal protein of 170 kDa (CEP170) [1].

Literature references

  1. Guarguaglini G, Duncan PI, Stierhof YD, Holmstrom T, Duensing S, Nigg EA;, Mol Biol Cell. 2005;16:1095-1107.: The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles. PUBMED:15616186 EPMC:15616186


External database links

This tab holds annotation information from the InterPro database.

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Domain organisation

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Alignments

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

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(14)
Full
(215)
Representative proteomes NCBI
(196)
Meta
(0)
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(4)
RP35
(11)
RP55
(30)
RP75
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  Seed
(14)
Full
(215)
Representative proteomes NCBI
(196)
Meta
(0)
RP15
(4)
RP35
(11)
RP55
(30)
RP75
(63)
Alignment:
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(14)
Full
(215)
Representative proteomes NCBI
(196)
Meta
(0)
RP15
(4)
RP35
(11)
RP55
(30)
RP75
(63)
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You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

External links

MyHits provides a collection of tools to handle multiple sequence alignments. For example, one can refine a seed alignment (sequence addition or removal, re-alignment or manual edition) and then search databases for remote homologs using HMMER3.

Pfam alignments:

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This family is new in this Pfam release.

Seed source: Jackhmmer:Q96L14
Previous IDs: none
Type: Family
Author: Eberhardt RY, Coggill P, Hetherington K
Number in seed: 14
Number in full: 215
Average length of the domain: 476.50 aa
Average identity of full alignment: 42 %
Average coverage of the sequence by the domain: 45.21 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 27.0 27.0
Trusted cut-off 61.9 48.6
Noise cut-off 20.6 22.8
Model length: 691
Family (HMM) version: 1
Download: download the raw HMM for this family

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