Summary: Phosphoprotein associated with glycosphingolipid-enriched
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Phosphoprotein associated with glycosphingolipid-enriched Provide feedback
PAG, or Cbp/PAG (Csk binding protein/phospho-protein associated with glycosphingolipid-enriched microdomains) is a transmembrane family that has a negative regulatory role in T-cell activation through being an adapter for C-terminal Src kinase, Csk. This family of proteins is found in eukaryotes.
Brdicka T, Pavlistova D, Leo A, Bruyns E, Korinek V, Angelisova P, Scherer J, Shevchenko A, Hilgert I, Cerny J, Drbal K, Kuramitsu Y, Kornacker B, Horejsi V, Schraven B;, J Exp Med. 2000;191:1591-1604.: Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation. PUBMED:10790433 EPMC:10790433
Brdickova N, Brdicka T, Andera L, Spicka J, Angelisova P, Milgram SL, Horejsi V;, FEBS Lett. 2001;507:133-136.: Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton. PUBMED:11684085 EPMC:11684085
Davidson D, Bakinowski M, Thomas ML, Horejsi V, Veillette A;, Mol Cell Biol. 2003;23:2017-2028.: Phosphorylation-dependent regulation of T-cell activation by PAG/Cbp, a lipid raft-associated transmembrane adaptor. PUBMED:12612075 EPMC:12612075
Kalland ME, Solheim SA, Skanland SS, Tasken K, Berge T;, Exp Cell Res. 2012;318:1611-1619.: Modulation of proximal signaling in normal and transformed B cells by transmembrane adapter Cbp/PAG. PUBMED:22659621 EPMC:22659621
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This family is new in this Pfam release.
|Number in seed:||5|
|Number in full:||46|
|Average length of the domain:||401.30 aa|
|Average identity of full alignment:||61 %|
|Average coverage of the sequence by the domain:||99.17 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||1|
|Download:||download the raw HMM for this family|
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