Summary: S100P-binding protein
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S100P-binding protein Provide feedback
S100PBPR is a family of proteins found in eukaryotes, and localised to cell nuclei where S100P is also present, and the two proteins co-immunoprecipitate. S100P is a member of the S100 family of calcium-binding proteins and there have been several recent reports of its over-expression in pancreatic ductal adenocarcinoma. In situ hybridisation shows S100PBPR transcripts to be found in islet cells but not duct cells of the healthy pancreas. An interaction between S100P and S100PBPR may be involved in early pancreatic cancer.
Dowen SE, Crnogorac-Jurcevic T, Gangeswaran R, Hansen M, Eloranta JJ, Bhakta V, Brentnall TA, Luttges J, Kloppel G, Lemoine NR;, Am J Pathol. 2005;166:81-92.: Expression of S100P and its novel binding partner S100PBPR in early pancreatic cancer. PUBMED:15632002 EPMC:15632002
Blaser H, Eisenbeiss S, Neumann M, Reichman-Fried M, Thisse B, Thisse C, Raz E;, J Cell Sci. 2005;118:4027-4038.: Transition from non-motile behaviour to directed migration during early PGC development in zebrafish. PUBMED:16129886 EPMC:16129886
Deng H, Shi J, Wilkerson M, Meschter S, Dupree W, Lin F;, Am J Clin Pathol. 2008;129:81-88.: Usefulness of S100P in diagnosis of adenocarcinoma of pancreas on fine-needle aspiration biopsy specimens. PUBMED:18089492 EPMC:18089492
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Curation and family details
This family is new in this Pfam release.
|Number in seed:||9|
|Number in full:||68|
|Average length of the domain:||252.40 aa|
|Average identity of full alignment:||51 %|
|Average coverage of the sequence by the domain:||84.12 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||1|
|Download:||download the raw HMM for this family|
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