Summary: Paramyxovirus non-structural protein c
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Paramyxovirus non-structural protein c Provide feedback
This family consist of the C proteins (C', C, Y1, Y2) found in Paramyxovirinae; human parainfluenza, and sendai virus. The C proteins effect viral RNA synthesis having both a positive and negative effect during the course of infection . Paramyxovirus have a negative strand ssRNA genome of 15.3kb form which six mRNAs are transcribed, five of these are monocistronic. The P/C mRNA is polycistronic and has two overlapping open reading frames P and C, C encodes the nested C proteins C', C, Y1 and Y2 .
Latorre P, Cadd T, Itoh M, Curran J, Kolakofsky D; , J Virol 1998;72:5984-5993.: The various Sendai virus C proteins are not functionally equivalent and exert both positive and negative effects on viral RNA accumulation during the course of infection. PUBMED:9621061 EPMC:9621061
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR002608
This family consist of the C proteins (C', C, Y1, Y2) found in the Paramyxovirinae, e.g. Human parainfluenza virus 3, and Sendai virus. The C proteins effect viral RNA synthesis having both a positive and negative effect during the course of infection [PUBMED:9621061]. The paramyxovirinae have a negative-strand ssRNA genome of 15.3 kb from which six mRNAs are transcribed, five of these are monocistronic. The P/C mRNA is polycistronic and has two overlapping open reading frames P and C, C encodes the nested C proteins C', C, Y1 and Y2 [PUBMED:2542021].
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|Biological process||evasion by virus of host immune response (GO:0030683)|
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Curation and family details
|Seed source:||Pfam-B_1202 (release 4.1)|
|Author:||Bashton M, Bateman A|
|Number in seed:||4|
|Number in full:||36|
|Average length of the domain:||194.90 aa|
|Average identity of full alignment:||70 %|
|Average coverage of the sequence by the domain:||97.69 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||13|
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