Summary: Translocation protein Sec62
Translocation protein Sec62 Provide feedback
No Pfam abstract.
External database links
|Transporter classification:||1.A.15 3.A.5|
This tab holds annotation information from the InterPro database.
InterPro entry IPR004728Members of the NSCC2 family have been sequenced from various yeast, fungal and animals species including Saccharomyces cerevisiae, Drosophila melanogaster and Homo sapiens. These proteins are the Sec62 proteins, believed to be associated with the Sec61 and Sec63 constituents of the general protein secretary systems of yeast microsomes. They are also the non-selective cation (NS) channels of the mammalian cytoplasmic membrane. The yeast Sec62 protein has been shown to be essential for cell growth. The mammalian NS channel proteins have been implicated in platelet derived growth factor(PGDF) dependent single channel current in fibroblasts. These channels are essentially closed in serum deprived tissue-culture cells and are specifically opened by exposure to PDGF. These channels are reported to exhibit equal selectivity for Na+, K+ and Cs+ with low permeability to Ca2+, and no permeability to anions.
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|Cellular component||integral to membrane (GO:0016021)|
|Molecular function||protein transporter activity (GO:0008565)|
|Biological process||protein transport (GO:0015031)|
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We make a range of alignments for each Pfam-A family:
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Curation and family details
|Author:||TIGRFAMs, Griffiths-Jones SR|
|Number in seed:||6|
|Number in full:||341|
|Average length of the domain:||199.00 aa|
|Average identity of full alignment:||29 %|
|Average coverage of the sequence by the domain:||55.86 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||11|
|Download:||download the raw HMM for this family|
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