Summary: Cell cycle regulatory protein
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Cell cycle regulatory protein Provide feedback
Speedy (Spy1) is a cell cycle regulatory protein which activates CDK2, the major kinase that allows progression through G1/S phase and further replication events . Spy1 expression overcomes a p27-induced cell cycle arrest to allow for DNA synthesis, so cell cycle progression occurs due to an interaction between Spy1 and p27 . Spy1 is also known as Ringo protein A.
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR020984
Speedy (Spy1) is a cell cycle regulatory protein which activates CDK2, the major kinase that allows progression through G1/S phase and further replication events. Spy1 expression overcomes a p27-induced cell cycle arrest to allow for DNA synthesis, so cell cycle progression occurs due to an interaction between Spy1 and p27 [PUBMED:17671428]. Spy1 is also known as Ringo protein A.
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Curation and family details
|Seed source:||Pfam-B_3875 (release 23.0)|
|Author:||Pollington J, Finn RD|
|Number in seed:||6|
|Number in full:||228|
|Average length of the domain:||110.50 aa|
|Average identity of full alignment:||46 %|
|Average coverage of the sequence by the domain:||48.09 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||3|
|Download:||download the raw HMM for this family|
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