Adenovirus minor core protein PV

No Pfam abstract.

InterPro entry IPR005608

The nucleoprotein core of adenoviruses consists of a double-stranded DNA molecule, with a covalently linked terminal protein at each end, in association with the highly basic protein VII and the mu peptide, and the more loosely associated protein V PUBMED:11038369. Protein V is also associated with the capsid and appears to provide a bridge between these two structures. After infection of the host cell, the capsid proteins become disassociated and the core is rapidly transported, in a process involving the cellular microtubules, to the nucleus where transcription of viral genes is initiated.

This entry represents protein V of adenoviruses. It has been suggested, though not proven, that this protein is involved in transport of the core virus particle to the nucleus through interaction with the cellular p32 protein PUBMED:9680131. p32 is a protein that is postulated, though again not proven, to be part of a rapid transport system between mitochondria and the nucleus. Protein V is not essential for viral reproduction, but its deletion leads to reduced thermostability and infectivity suggesting that it may play some role in viral assembly PUBMED:17208253.

Gene Ontology

External database links

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Very large alignments can often cause problems for the formatting tool above. If you find that downloading or viewing a large alignment is problematic, you can also download a gzip-compressed, Stockholm-format file containing the seed or full alignment for this family.

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

The main seed and full alignments are generated using sequences from the UniProt sequence database. However, we also generate alignments using sequences from the NCBI sequence database and the "metaseq" metagenomics dataset.

You can view alignments from these two additional datasets using the form above, or you can download alignments of NCBI or metagenomics sequences, as gzip-compressed files.

External links

MyHits provides a collection of tools to handle multiple sequence alignments. For example, one can refine a seed alignment (sequence addition or removal, re-alignment or manual edition) and then search databases for remote homologs using HMMER2.

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

This page displays the phylogenetic tree for this family. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed or full alignments.

Note: You can also download the data files for the seed, full, NCBI or metagenomics trees.

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation

HMM information