Summary
This is the summary of UniProt entry A0MJA6_MACFA (A0MJA6).
| Description: | Niemann-Pick C1-like 1 protein |
| Source organism: |
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
(NCBI taxonomy ID
9541)
View Pfam proteome data. |
| Length: | 1332 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| Pfam B | Pfam-B_7269 | 1 | 239 |
| sig_p | n/a | 1 | 21 |
| low_complexity | n/a | 2 | 19 |
| transmembrane | n/a | 284 | 305 |
| disorder | n/a | 316 | 319 |
| Pfam B | Pfam-B_10706 | 341 | 475 |
| transmembrane | n/a | 351 | 372 |
| low_complexity | n/a | 352 | 366 |
| low_complexity | n/a | 436 | 455 |
| Pfam B | Pfam-B_19481 | 477 | 555 |
| transmembrane | n/a | 633 | 654 |
| Pfam A | Sterol-sensing | 661 | 815 |
| transmembrane | n/a | 666 | 690 |
| low_complexity | n/a | 668 | 685 |
| transmembrane | n/a | 696 | 719 |
| transmembrane | n/a | 739 | 761 |
| transmembrane | n/a | 773 | 797 |
| transmembrane | n/a | 843 | 864 |
| low_complexity | n/a | 847 | 861 |
| Pfam A | Patched | 1062 | 1267 |
| low_complexity | n/a | 1064 | 1074 |
| transmembrane | n/a | 1113 | 1133 |
| low_complexity | n/a | 1129 | 1144 |
| transmembrane | n/a | 1140 | 1161 |
| transmembrane | n/a | 1167 | 1185 |
| transmembrane | n/a | 1206 | 1230 |
| low_complexity | n/a | 1238 | 1258 |
| transmembrane | n/a | 1242 | 1265 |
| low_complexity | n/a | 1272 | 1290 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession A0MJA6. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MAEAGLRGWL LWALLLHLAQ SEPYTPIHQP GYCAFYDECG KNPELSGGLM
50 51
TLSNVSCLSN TPARNITGDH LILLQRICPR LYTGPNTQAC CSAKQLVSLE
100 101
ASLSITKALL TRCPACSDNF VSLHCHNTCS PNQSLFINVT RVAQLGAGQL
150 151
PAVVAYEAFY QHSFAEQSYD SCSRVHIPAA ATLAVGSMCG VYGSALCNAQ
200 201
RWLNFQGDTG NGLAPLDITF HLLEPGQAVG SGIQPLNEGV ARCNESQGDD
250 251
AVACSCQDCA ASCPAIAHPQ ALDSTFRLGR MPGGLVLIII LCSVFTVVAI
300 301
LLVGLRVAPT RDKSKTVDPK KGTSLSDKLS FSTHTLLGQF FQGWGTWVAS
350 351
WPLTILVLSV IPVVVLAAGL VFTELTTDPV ELWSAPNSQA RSEKAFHDQH
400 401
FGPFFRTNQV ILTAPNRSSY RYDSLLLGPK NFSGILDLDL LLELLELQER
450 451
LRHLQVWSPE AQRNISLQHI CYAPLNPDNT SLSDCCINSL LQYFQNNRTL
500 501
LLLTANQTLM GQTSQVDWRD HFLYCANAPL TFKDGTALAL SCMADYGAPV
550 551
FPFLAVGGYK GKDYSEAEAL IMTFSLNNYP AGDPRLAQAQ LWEEAFLEEM
600 601
RAFQRRTAGK FQVTFMAERS LEDEINRTTA EDLPIFATSY IVIFLYISLA
650 651
LGSYSSWSRV MVDSKATLGL GGVAVVLGAV MAAMGFFSYL GIRSSLIILQ
700 701
VVPFLVLSVG ADNIFIFVLE YQRLPRRPGE PREVHIGRAL GRVAPSMLLC
750 751
SLSEAICFFL GALTPMPAVR TFALTSGLAV VLDFLLQMSA FVALLSLDSK
800 801
RQEASRLDVC CCVKPRELPL PGQGEGFLLG LFRKAYVPFL LHWITRGVVL
850 851
LLFLALFGVS LYYMCHISVG LDQELALPKD SYLLDYFLFL NRYFETGAPV
900 901
YFVTTSGYNF SSEAGMNAIC SSAGCNNFSF TQKIQYATEF PEQSYLAIPA
950 951
SSWVDDFIDW LTPSSCCRLY ISGPNKDQFC PSTVNSLNCL KNCLSITMGS
1000 1001
VRPSVEQFYK YLPWFLNDRP NIKCPKGGLG AYSTSVNLTS DGQVLASRFM
1050 1051
AYHKPLKNSQ DYTEALRAAR ELAANITADL RKVPGTDPAF EVFPYTVTNV
1100 1101
FYEQYLTILP EGLFMLSLCL VPTFAVCCLL LGLDLRSGLL NLLSIIMILV
1150 1151
DTVGFMALWG ISYNAVSLIN LVSAVGMSVE FVSHITRSFA ISTKPTRLER
1200 1201
AKEATISMGS AVFAGVAMTN LPGILVLGLA KAQLIQIFFF RLNLLITLLG
1250 1251
LLHGLVFLPV ILSYVGPDIN PALALEQKLA EEAAAAAIAA SYPNHPSRVS
1300 1301
TADNIYVNHS FEGSIKGAGA VSNFLPNNGR QF
1332
Show the unformatted sequence. |
| Checksums: |
CRC64:B983F0EBD7E0EFD8
MD5:d73ac259b7a69735034815a9e42e8ac5
|
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.