Summary
This is the summary of UniProt entry ODPX_HUMAN (O00330).
| Description: | Pyruvate dehydrogenase protein X component, mitochondrial |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
View Pfam proteome data. |
| Length: | 501 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| Pfam A | Biotin_lipoyl | 57 | 131 |
| disorder | n/a | 139 | 173 |
| low_complexity | n/a | 141 | 170 |
| disorder | n/a | 179 | 180 |
| Pfam A | E3_binding | 180 | 218 |
| disorder | n/a | 191 | 216 |
| disorder | n/a | 221 | 275 |
| low_complexity | n/a | 233 | 251 |
| Pfam A | 2-oxoacid_dh | 272 | 501 |
| disorder | n/a | 462 | 463 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession O00330. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MAASWRLGCD PRLLRYLVGF PGRRSVGLVK GALGWSVSRG ANWRWFHSTQ
50 51
WLRGDPIKIL MPSLSPTMEE GNIVKWLKKE GEAVSAGDAL CEIETDKAVV
100 101
TLDASDDGIL AKIVVEEGSK NIRLGSLIGL IVEEGEDWKH VEIPKDVGPP
150 151
PPVSKPSEPR PSPEPQISIP VKKEHIPGTL RFRLSPAARN ILEKHSLDAS
200 201
QGTATGPRGI FTKEDALKLV QLKQTGKITE SRPTPAPTAT PTAPSPLQAT
250 251
AGPSYPRPVI PPVSTPGQPN AVGTFTEIPA SNIRRVIAKR LTESKSTVPH
300 301
AYATADCDLG AVLKVRQDLV KDDIKVSVND FIIKAAAVTL KQMPDVNVSW
350 351
DGEGPKQLPF IDISVAVATD KGLLTPIIKD AAAKGIQEIA DSVKALSKKA
400 401
RDGKLLPEEY QGGSFSISNL GMFGIDEFTA VINPPQACIL AVGRFRPVLK
450 451
LTEDEEGNAK LQQRQLITVT MSSDSRVVDD ELATRFLKSF KANLENPIRL
500 501
A
501
Show the unformatted sequence. |
| Checksums: |
CRC64:9CF0C1DAE9E12EF9
MD5:9ab33d8d8e33ab025570b12a0abd6c34
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| Biotin_lipoyl | 57 - 131 | 2DNC | A | 8 - 82 | Jmol AstexViewer SPICE |
| E3_binding | 180 - 218 | 2F60 | K | 127 - 165 | Jmol AstexViewer SPICE |
| 183 - 218 | 1ZY8 | K | 130 - 165 | Jmol AstexViewer SPICE | |
| L | 130 - 165 | Jmol AstexViewer SPICE | |||
| M | 130 - 165 | Jmol AstexViewer SPICE | |||
| N | 130 - 165 | Jmol AstexViewer SPICE | |||
| O | 130 - 165 | Jmol AstexViewer SPICE | |||
| 2F5Z | K | 130 - 165 | Jmol AstexViewer SPICE | ||
| L | 130 - 165 | Jmol AstexViewer SPICE | |||
| M | 130 - 165 | Jmol AstexViewer SPICE | |||
| N | 130 - 165 | Jmol AstexViewer SPICE | |||
| O | 130 - 165 | Jmol AstexViewer SPICE |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.