Summary
This is the summary of UniProt entry PLXB1_HUMAN (O43157).
| Description: | Plexin-B1 |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
View Pfam proteome data. |
| Length: | 2135 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| sig_p | n/a | 1 | 19 |
| disorder | n/a | 31 | 35 |
| Pfam A | Sema | 35 | 460 |
| disorder | n/a | 75 | 76 |
| disorder | n/a | 79 | 97 |
| low_complexity | n/a | 120 | 138 |
| disorder | n/a | 129 | 131 |
| disorder | n/a | 141 | 144 |
| low_complexity | n/a | 168 | 180 |
| disorder | n/a | 308 | 309 |
| low_complexity | n/a | 310 | 320 |
| disorder | n/a | 340 | 341 |
| disorder | n/a | 375 | 378 |
| disorder | n/a | 382 | 391 |
| disorder | n/a | 443 | 447 |
| Pfam A | PSI | 481 | 529 |
| low_complexity | n/a | 507 | 516 |
| disorder | n/a | 671 | 889 |
| low_complexity | n/a | 682 | 710 |
| low_complexity | n/a | 734 | 754 |
| low_complexity | n/a | 757 | 764 |
| low_complexity | n/a | 951 | 968 |
| Pfam A | TIG | 1070 | 1159 |
| disorder | n/a | 1086 | 1087 |
| disorder | n/a | 1089 | 1090 |
| disorder | n/a | 1139 | 1146 |
| disorder | n/a | 1150 | 1156 |
| Pfam A | TIG | 1162 | 1248 |
| disorder | n/a | 1168 | 1172 |
| disorder | n/a | 1179 | 1180 |
| disorder | n/a | 1210 | 1222 |
| disorder | n/a | 1228 | 1229 |
| disorder | n/a | 1247 | 1251 |
| Pfam A | TIG | 1252 | 1374 |
| disorder | n/a | 1257 | 1259 |
| disorder | n/a | 1298 | 1302 |
| disorder | n/a | 1305 | 1306 |
| disorder | n/a | 1375 | 1397 |
| disorder | n/a | 1446 | 1453 |
| transmembrane | n/a | 1491 | 1511 |
| coiled_coil | n/a | 1515 | 1535 |
| Pfam A | Plexin_cytopl | 1561 | 2102 |
| disorder | n/a | 1587 | 1592 |
| disorder | n/a | 1800 | 1803 |
| disorder | n/a | 1864 | 1872 |
| disorder | n/a | 1883 | 1906 |
| low_complexity | n/a | 1892 | 1910 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession O43157. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MPALGPALLQ ALWAGWVLTL QPLPPTAFTP NGTYLQHLAR DPTSGTLYLG
50 51
ATNFLFQLSP GLQLEATVST GPVLDSRDCL PPVMPDECPQ AQPTNNPNQL
100 101
LLVSPGALVV CGSVHQGVCE QRRLGQLEQL LLRPERPGDT QYVAANDPAV
150 151
STVGLVAQGL AGEPLLFVGR GYTSRGVGGG IPPITTRALW PPDPQAAFSY
200 201
EETAKLAVGR LSEYSHHFVS AFARGASAYF LFLRRDLQAQ SRAFRAYVSR
250 251
VCLRDQHYYS YVELPLACEG GRYGLIQAAA VATSREVAHG EVLFAAFSSA
300 301
APPTVGRPPS AAAGASGASA LCAFPLDEVD RLANRTRDAC YTREGRAEDG
350 351
TEVAYIEYDV NSDCAQLPVD TLDAYPCGSD HTPSPMASRV PLEATPILEW
400 401
PGIQLTAVAV TMEDGHTIAF LGDSQGQLHR VYLGPGSDGH PYSTQSIQQG
450 451
SAVSRDLTFD GTFEHLYVMT QSTLLKVPVA SCAQHLDCAS CLAHRDPYCG
500 501
WCVLLGRCSR RSECSRGQGP EQWLWSFQPE LGCLQVAAMS PANISREETR
550 551
EVFLSVPDLP PLWPGESYSC HFGEHQSPAL LTGSGVMCPS PDPSEAPVLP
600 601
RGADYVSVSV ELRFGAVVIA KTSLSFYDCV AVTELRPSAQ CQACVSSRWG
650 651
CNWCVWQHLC THKASCDAGP MVASHQSPLV SPDPPARGGP SPSPPTAPKA
700 701
LATPAPDTLP VEPGAPSTAT ASDISPGASP SLLSPWGPWA GSGSISSPGS
750 751
TGSPLHEEPS PPSPQNGPGT AVPAPTDFRP SATPEDLLAS PLSPSEVAAV
800 801
PPADPGPEAL HPTVPLDLPP ATVPATTFPG AMGSVKPALD WLTREGGELP
850 851
EADEWTGGDA PAFSTSTLLS GDGDSAELEG PPAPLILPSS LDYQYDTPGL
900 901
WELEEATLGA SSCPCVESVQ GSTLMPVHVE REIRLLGRNL HLFQDGPGDN
950 951
ECVMELEGLE VVVEARVECE PPPDTQCHVT CQQHQLSYEA LQPELRVGLF
1000 1001
LRRAGRLRVD SAEGLHVVLY DCSVGHGDCS RCQTAMPQYG CVWCEGERPR
1050 1051
CVTREACGEA EAVATQCPAP LIHSVEPLTG PVDGGTRVTI RGSNLGQHVQ
1100 1101
DVLGMVTVAG VPCAVDAQEY EVSSSLVCIT GASGEEVAGA TAVEVPGRGR
1150 1151
GVSEHDFAYQ DPKVHSIFPA RGPRAGGTRL TLNGSKLLTG RLEDIRVVVG
1200 1201
DQPCHLLPEQ QSEQLRCETS PRPTPATLPV AVWFGATERR LQRGQFKYTL
1250 1251
DPNITSAGPT KSFLSGGREI CVRGQNLDVV QTPRIRVTVV SRMLQPSQGL
1300 1301
GRRRRVVPET ACSLGPSCSS QQFEEPCHVN SSQLITCRTP ALPGLPEDPW
1350 1351
VRVEFILDNL VFDFATLNPT PFSYEADPTL QPLNPEDPTM PFRHKPGSVF
1400 1401
SVEGENLDLA MSKEEVVAMI GDGPCVVKTL TRHHLYCEPP VEQPLPRHHA
1450 1451
LREAPDSLPE FTVQMGNLRF SLGHVQYDGE SPGAFPVAAQ VGLGVGTSLL
1500 1501
ALGVIIIVLM YRRKSKQALR DYKKVQIQLE NLESSVRDRC KKEFTDLMTE
1550 1551
MTDLTSDLLG SGIPFLDYKV YAERIFFPGH RESPLHRDLG VPESRRPTVE
1600 1601
QGLGQLSNLL NSKLFLTKFI HTLESQRTFS ARDRAYVASL LTVALHGKLE
1650 1651
YFTDILRTLL SDLVAQYVAK NPKLMLRRTE TVVEKLLTNW MSICLYTFVR
1700 1701
DSVGEPLYML FRGIKHQVDK GPVDSVTGKA KYTLNDNRLL REDVEYRPLT
1750 1751
LNALLAVGPG AGEAQGVPVK VLDCDTISQA KEKMLDQLYK GVPLTQRPDP
1800 1801
RTLDVEWRSG VAGHLILSDE DVTSEVQGLW RRLNTLQHYK VPDGATVALV
1850 1851
PCLTKHVLRE NQDYVPGERT PMLEDVDEGG IRPWHLVKPS DEPEPPRPRR
1900 1901
GSLRGGERER AKAIPEIYLT RLLSMKGTLQ KFVDDLFQVI LSTSRPVPLA
1950 1951
VKYFFDLLDE QAQQHGISDQ DTIHIWKTNS LPLRFWINII KNPQFVFDVQ
2000 2001
TSDNMDAVLL VIAQTFMDAC TLADHKLGRD SPINKLLYAR DIPRYKRMVE
2050 2051
RYYADIRQTV PASDQEMNSV LAELSWNYSG DLGARVALHE LYKYINKYYD
2100 2101
QIITALEEDG TAQKMQLGYR LQQIAAAVEN KVTDL
2135
Show the unformatted sequence. |
| Checksums: |
CRC64:12A81B68AF1D340F
MD5:c88eeb35f895084b1337a95e610a1c32
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| Plexin_cytopl | 1561 - 2102 | 3SU8 | X | 1561 - 2102 | Jmol AstexViewer SPICE |
| 1563 - 2102 | 3HM6 | X | 1563 - 2102 | Jmol AstexViewer SPICE | |
| 3SUA | D | 1563 - 2102 | Jmol AstexViewer SPICE | ||
| E | 1563 - 2102 | Jmol AstexViewer SPICE | |||
| F | 1563 - 2102 | Jmol AstexViewer SPICE | |||
| 1743 - 1862 | 2JPH | A | 3 - 122 | Jmol AstexViewer SPICE | |
| 1746 - 1852 | 2R2O | A | 1746 - 1852 | Jmol AstexViewer SPICE | |
| B | 1746 - 1852 | Jmol AstexViewer SPICE | |||
| 2REX | A | 1746 - 1852 | Jmol AstexViewer SPICE | ||
| C | 1746 - 1852 | Jmol AstexViewer SPICE | |||
| PSI | 481 - 529 | 3OL2 | B | 481 - 529 | Jmol AstexViewer SPICE |
| Sema | 35 - 460 | 3OL2 | B | 35 - 460 | Jmol AstexViewer SPICE |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.