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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: OREX_HUMAN (O43612)

Summary

This is the summary of UniProt entry OREX_HUMAN (O43612).

Description: Orexin
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 131 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
Pfam A Orexin 1 131
sig_p n/a 1 33
low_complexity n/a 15 37
disorder n/a 67 68
low_complexity n/a 72 85
disorder n/a 77 82
disorder n/a 96 98
low_complexity n/a 116 130

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession O43612. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MNLPSTKVSW AAVTLLLLLL LLPPALLSSG AAAQPLPDCC RQKTCSCRLY
50
51
ELLHGAGNHA AGILTLGKRR SGPPGLQGRL QRLLQASGNH AAGILTMGRR
100
101
AGAEPAPRPC LGRRCSAPAA ASVAPGGQSG I                    
131
 

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Checksums:
CRC64:139D9C33E39E4EF1
MD5:dcec6c1c6f250e370370ae21cc550186

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Orexin 1 - 13 1UVQ C 1 - 13 Jmol AstexViewer SPICE
34 - 66 1R02 A 1 - 33 Jmol AstexViewer SPICE
35 - 66 1WSO A 2 - 33 Jmol AstexViewer SPICE
71 - 97 1CQ0 A 2 - 28 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.