Summary
This is the summary of UniProt entry ACTN4_HUMAN (O43707).
| Description: | Alpha-actinin-4 |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
View Pfam proteome data. |
| Length: | 911 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| Pfam B | Pfam-B_7425 | 1 | 52 |
| disorder | n/a | 13 | 20 |
| low_complexity | n/a | 14 | 29 |
| disorder | n/a | 22 | 30 |
| Pfam A | CH | 53 | 154 |
| disorder | n/a | 102 | 104 |
| Pfam A | CH | 166 | 269 |
| Pfam A | Spectrin | 293 | 403 |
| disorder | n/a | 377 | 378 |
| disorder | n/a | 383 | 385 |
| Pfam A | Spectrin | 413 | 518 |
| coiled_coil | n/a | 449 | 483 |
| disorder | n/a | 516 | 517 |
| Pfam A | Spectrin | 528 | 639 |
| disorder | n/a | 574 | 575 |
| disorder | n/a | 584 | 585 |
| disorder | n/a | 601 | 603 |
| disorder | n/a | 605 | 606 |
| disorder | n/a | 634 | 652 |
| Pfam A | Spectrin | 649 | 752 |
| Pfam A | EF-hand_6 | 769 | 798 |
| disorder | n/a | 812 | 813 |
| Pfam A | EFhand_Ca_insen | 841 | 907 |
| disorder | n/a | 866 | 867 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession O43707. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MVDYHAANQS YQYGPSSAGN GAGGGGSMGD YMAQEDDWDR DLLLDPAWEK
50 51
QQRKTFTAWC NSHLRKAGTQ IENIDEDFRD GLKLMLLLEV ISGERLPKPE
100 101
RGKMRVHKIN NVNKALDFIA SKGVKLVSIG AEEIVDGNAK MTLGMIWTII
150 151
LRFAIQDISV EETSAKEGLL LWCQRKTAPY KNVNVQNFHI SWKDGLAFNA
200 201
LIHRHRPELI EYDKLRKDDP VTNLNNAFEV AEKYLDIPKM LDAEDIVNTA
250 251
RPDEKAIMTY VSSFYHAFSG AQKAETAANR ICKVLAVNQE NEHLMEDYEK
300 301
LASDLLEWIR RTIPWLEDRV PQKTIQEMQQ KLEDFRDYRR VHKPPKVQEK
350 351
CQLEINFNTL QTKLRLSNRP AFMPSEGKMV SDINNGWQHL EQAEKGYEEW
400 401
LLNEIRRLER LDHLAEKFRQ KASIHEAWTD GKEAMLKHRD YETATLSDIK
450 451
ALIRKHEAFE SDLAAHQDRV EQIAAIAQEL NELDYYDSHN VNTRCQKICD
500 501
QWDALGSLTH SRREALEKTE KQLEAIDQLH LEYAKRAAPF NNWMESAMED
550 551
LQDMFIVHTI EEIEGLISAH DQFKSTLPDA DREREAILAI HKEAQRIAES
600 601
NHIKLSGSNP YTTVTPQIIN SKWEKVQQLV PKRDHALLEE QSKQQSNEHL
650 651
RRQFASQANV VGPWIQTKME EIGRISIEMN GTLEDQLSHL KQYERSIVDY
700 701
KPNLDLLEQQ HQLIQEALIF DNKHTNYTME HIRVGWEQLL TTIARTINEV
750 751
ENQILTRDAK GISQEQMQEF RASFNHFDKD HGGALGPEEF KACLISLGYD
800 801
VENDRQGEAE FNRIMSLVDP NHSGLVTFQA FIDFMSRETT DTDTADQVIA
850 851
SFKVLAGDKN FITAEELRRE LPPDQAEYCI ARMAPYQGPD AVPGALDYKS
900 901
FSTALYGESD L
911
Show the unformatted sequence. |
| Checksums: |
CRC64:461580C3F22937D1
MD5:3789ab974b87069e27ca8cb710aed338
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| CH | 166 - 269 | 2R0O | A | 166 - 269 | Jmol AstexViewer SPICE |
| B | 166 - 269 | Jmol AstexViewer SPICE | |||
| 53 - 154 | 2R0O | A | 53 - 154 | Jmol AstexViewer SPICE | |
| B | 53 - 154 | Jmol AstexViewer SPICE | |||
| Spectrin | 528 - 639 | 1WLX | A | 12 - 123 | Jmol AstexViewer SPICE |
| 734 - 752 | 1YDI | B | 741 - 759 | Jmol AstexViewer SPICE |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.