Summary
This is the summary of UniProt entry TLX2_HUMAN (O43763).
| Description: | T-cell leukemia homeobox protein 2 |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
View Pfam proteome data. |
| Length: | 284 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| disorder | n/a | 1 | 57 |
| low_complexity | n/a | 27 | 48 |
| disorder | n/a | 60 | 108 |
| low_complexity | n/a | 61 | 80 |
| low_complexity | n/a | 83 | 116 |
| disorder | n/a | 131 | 133 |
| disorder | n/a | 137 | 165 |
| Pfam A | Homeobox | 158 | 214 |
| low_complexity | n/a | 182 | 194 |
| disorder | n/a | 212 | 220 |
| low_complexity | n/a | 217 | 252 |
| disorder | n/a | 223 | 227 |
| disorder | n/a | 229 | 231 |
| disorder | n/a | 234 | 235 |
| disorder | n/a | 238 | 248 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession O43763. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MEPGMLGPHN LPHHEPISFG IDQILSGPET PGGGLGLGRG GQGHGENGAF
50 51
SGGYHGASGY GPAGSLAPLP GSSGVGPGGV IRVPAHRPLP VPPPAGGAPA
100 101
VPGPSGLGGA GGLAGLTFPW MDSGRRFAKD RLTAALSPFS GTRRIGHPYQ
150 151
NRTPPKRKKP RTSFSRSQVL ELERRFLRQK YLASAERAAL AKALRMTDAQ
200 201
VKTWFQNRRT KWRRQTAEER EAERHRAGRL LLHLQQDALP RPLRPPLPPD
250 251
PLCLHNSSLF ALQNLQPWAE DNKVASVSGL ASVV
284
Show the unformatted sequence. |
| Checksums: |
CRC64:794B07A9E7817939
MD5:f5c706dd6676a2eea99993102fb9055d
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| Homeobox | 164 - 214 | 3A03 | A | 164 - 214 | Jmol AstexViewer SPICE |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.