Summary
This is the summary of UniProt entry GABR2_HUMAN (O75899).
| Description: | Gamma-aminobutyric acid type B receptor subunit 2 |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
View Pfam proteome data. |
| Length: | 941 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| disorder | n/a | 1 | 19 |
| sig_p | n/a | 1 | 45 |
| low_complexity | n/a | 10 | 64 |
| disorder | n/a | 54 | 56 |
| Pfam A | ANF_receptor | 76 | 427 |
| disorder | n/a | 333 | 345 |
| Pfam B | Pfam-B_19518 | 429 | 468 |
| transmembrane | n/a | 479 | 502 |
| Pfam A | 7tm_3 | 491 | 747 |
| transmembrane | n/a | 522 | 543 |
| transmembrane | n/a | 555 | 576 |
| low_complexity | n/a | 583 | 601 |
| transmembrane | n/a | 597 | 618 |
| transmembrane | n/a | 653 | 676 |
| transmembrane | n/a | 696 | 712 |
| transmembrane | n/a | 718 | 741 |
| disorder | n/a | 758 | 768 |
| disorder | n/a | 771 | 779 |
| disorder | n/a | 783 | 786 |
| disorder | n/a | 788 | 790 |
| coiled_coil | n/a | 788 | 815 |
| disorder | n/a | 810 | 814 |
| disorder | n/a | 816 | 828 |
| disorder | n/a | 837 | 840 |
| disorder | n/a | 849 | 884 |
| Pfam B | Pfam-B_46 | 871 | 939 |
| disorder | n/a | 886 | 887 |
| disorder | n/a | 921 | 922 |
| disorder | n/a | 925 | 927 |
| disorder | n/a | 929 | 935 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession O75899. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MASPRSSGQP GPPPPPPPPP ARLLLLLLLP LLLPLAPGAW GWARGAPRPP
50 51
PSSPPLSIMG LMPLTKEVAK GSIGRGVLPA VELAIEQIRN ESLLRPYFLD
100 101
LRLYDTECDN AKGLKAFYDA IKYGPNHLMV FGGVCPSVTS IIAESLQGWN
150 151
LVQLSFAATT PVLADKKKYP YFFRTVPSDN AVNPAILKLL KHYQWKRVGT
200 201
LTQDVQRFSE VRNDLTGVLY GEDIEISDTE SFSNDPCTSV KKLKGNDVRI
250 251
ILGQFDQNMA AKVFCCAYEE NMYGSKYQWI IPGWYEPSWW EQVHTEANSS
300 301
RCLRKNLLAA MEGYIGVDFE PLSSKQIKTI SGKTPQQYER EYNNKRSGVG
350 351
PSKFHGYAYD GIWVIAKTLQ RAMETLHASS RHQRIQDFNY TDHTLGRIIL
400 401
NAMNETNFFG VTGQVVFRNG ERMGTIKFTQ FQDSREVKVG EYNAVADTLE
450 451
IINDTIRFQG SEPPKDKTII LEQLRKISLP LYSILSALTI LGMIMASAFL
500 501
FFNIKNRNQK LIKMSSPYMN NLIILGGMLS YASIFLFGLD GSFVSEKTFE
550 551
TLCTVRTWIL TVGYTTAFGA MFAKTWRVHA IFKNVKMKKK IIKDQKLLVI
600 601
VGGMLLIDLC ILICWQAVDP LRRTVEKYSM EPDPAGRDIS IRPLLEHCEN
650 651
THMTIWLGIV YAYKGLLMLF GCFLAWETRN VSIPALNDSK YIGMSVYNVG
700 701
IMCIIGAAVS FLTRDQPNVQ FCIVALVIIF CSTITLCLVF VPKLITLRTN
750 751
PDAATQNRRF QFTQNQKKED SKTSTSVTSV NQASTSRLEG LQSENHRLRM
800 801
KITELDKDLE EVTMQLQDTP EKTTYIKQNH YQELNDILNL GNFTESTDGG
850 851
KAILKNHLDQ NPQLQWNTTE PSRTCKDPIE DINSPEHIQR RLSLQLPILH
900 901
HAYLPSIGGV DASCVSPCVS PTASPRHRHV PPSFRVMVSG L
941
Show the unformatted sequence. |
| Checksums: |
CRC64:09F1773DB0673C5D
MD5:08040fb9c44fc49546749460463d5028
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| ANF_receptor | 76 - 427 | 4F11 | A | 76 - 427 | Jmol AstexViewer SPICE |
| 4F12 | A | 76 - 427 | Jmol AstexViewer SPICE |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.