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25  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: GSHR_HUMAN (P00390)

Summary

This is the summary of UniProt entry GSHR_HUMAN (P00390).

Description: Glutathione reductase, mitochondrial EC=1.8.1.7
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 522 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
low_complexity n/a 17 30
disorder n/a 41 42
disorder n/a 45 55
low_complexity n/a 50 61
Pfam A Pyr_redox_2 66 380
low_complexity n/a 71 94
disorder n/a 202 204
disorder n/a 209 212
Pfam A Pyr_redox 233 312
Pfam A Pyr_redox_dim 411 522
disorder n/a 521 522

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P00390. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MALLPRALSA GAGPSWRRAA RAFRGFLLLL PEPAALTRAL SRAMACRQEP
50
51
QPQGPPPAAG AVASYDYLVI GGGSGGLASA RRAAELGARA AVVESHKLGG
100
101
TCVNVGCVPK KVMWNTAVHS EFMHDHADYG FPSCEGKFNW RVIKEKRDAY
150
151
VSRLNAIYQN NLTKSHIEII RGHAAFTSDP KPTIEVSGKK YTAPHILIAT
200
201
GGMPSTPHES QIPGASLGIT SDGFFQLEEL PGRSVIVGAG YIAVEMAGIL
250
251
SALGSKTSLM IRHDKVLRSF DSMISTNCTE ELENAGVEVL KFSQVKEVKK
300
301
TLSGLEVSMV TAVPGRLPVM TMIPDVDCLL WAIGRVPNTK DLSLNKLGIQ
350
351
TDDKGHIIVD EFQNTNVKGI YAVGDVCGKA LLTPVAIAAG RKLAHRLFEY
400
401
KEDSKLDYNN IPTVVFSHPP IGTVGLTEDE AIHKYGIENV KTYSTSFTPM
450
451
YHAVTKRKTK CVMKMVCANK EEKVVGIHMQ GLGCDEMLQG FAVAVKMGAT
500
501
KADFDNTVAI HPTSSEELVT LR                              
522
 

Show the unformatted sequence.

Checksums:
CRC64:DD8E2BA9D6E3757B
MD5:092d76e9bc45a52e22adc12123c79581

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Pyr_redox 233 - 312 1BWC A 189 - 268 Jmol AstexViewer SPICE
1DNC A 189 - 268 Jmol AstexViewer SPICE
1GRA A 189 - 268 Jmol AstexViewer SPICE
1GRB A 189 - 268 Jmol AstexViewer SPICE
1GRE A 189 - 268 Jmol AstexViewer SPICE
1GRF A 189 - 268 Jmol AstexViewer SPICE
1GRG A 189 - 268 Jmol AstexViewer SPICE
1GRT A 189 - 268 Jmol AstexViewer SPICE
1GSN A 189 - 268 Jmol AstexViewer SPICE
1XAN A 189 - 268 Jmol AstexViewer SPICE
2AAQ A 189 - 268 Jmol AstexViewer SPICE
2GH5 A 189 - 268 Jmol AstexViewer SPICE
B 189 - 268 Jmol AstexViewer SPICE
2GRT A 189 - 268 Jmol AstexViewer SPICE
3DJG X 189 - 268 Jmol AstexViewer SPICE
3DJJ A 189 - 268 Jmol AstexViewer SPICE
3DK4 A 189 - 268 Jmol AstexViewer SPICE
3DK8 A 189 - 268 Jmol AstexViewer SPICE
3DK9 A 189 - 268 Jmol AstexViewer SPICE
3GRS A 189 - 268 Jmol AstexViewer SPICE
3GRT A 189 - 268 Jmol AstexViewer SPICE
3SQP A 189 - 268 Jmol AstexViewer SPICE
B 189 - 268 Jmol AstexViewer SPICE
4GR1 A 189 - 268 Jmol AstexViewer SPICE
4GRT A 189 - 268 Jmol AstexViewer SPICE
5GRT A 189 - 268 Jmol AstexViewer SPICE
Pyr_redox_2 66 - 380 1BWC A 22 - 336 Jmol AstexViewer SPICE
1DNC A 22 - 336 Jmol AstexViewer SPICE
1GRA A 22 - 336 Jmol AstexViewer SPICE
1GRB A 22 - 336 Jmol AstexViewer SPICE
1GRE A 22 - 336 Jmol AstexViewer SPICE
1GRF A 22 - 336 Jmol AstexViewer SPICE
1GRG A 22 - 336 Jmol AstexViewer SPICE
1GRT A 22 - 336 Jmol AstexViewer SPICE
1GSN A 22 - 336 Jmol AstexViewer SPICE
1XAN A 22 - 336 Jmol AstexViewer SPICE
2AAQ A 22 - 336 Jmol AstexViewer SPICE
2GH5 A 22 - 336 Jmol AstexViewer SPICE
B 22 - 336 Jmol AstexViewer SPICE
2GRT A 22 - 336 Jmol AstexViewer SPICE
3DJG X 22 - 336 Jmol AstexViewer SPICE
3DJJ A 22 - 336 Jmol AstexViewer SPICE
3DK4 A 22 - 336 Jmol AstexViewer SPICE
3DK8 A 22 - 336 Jmol AstexViewer SPICE
3DK9 A 22 - 336 Jmol AstexViewer SPICE
3GRS A 22 - 336 Jmol AstexViewer SPICE
3GRT A 22 - 336 Jmol AstexViewer SPICE
3SQP A 22 - 336 Jmol AstexViewer SPICE
B 22 - 336 Jmol AstexViewer SPICE
4GR1 A 22 - 336 Jmol AstexViewer SPICE
4GRT A 22 - 336 Jmol AstexViewer SPICE
5GRT A 22 - 336 Jmol AstexViewer SPICE
Pyr_redox_dim 411 - 522 1BWC A 367 - 478 Jmol AstexViewer SPICE
1DNC A 367 - 478 Jmol AstexViewer SPICE
1GRA A 367 - 478 Jmol AstexViewer SPICE
1GRB A 367 - 478 Jmol AstexViewer SPICE
1GRE A 367 - 478 Jmol AstexViewer SPICE
1GRF A 367 - 478 Jmol AstexViewer SPICE
1GRG A 367 - 478 Jmol AstexViewer SPICE
1GRT A 367 - 478 Jmol AstexViewer SPICE
1GSN A 367 - 478 Jmol AstexViewer SPICE
1XAN A 367 - 478 Jmol AstexViewer SPICE
2AAQ A 367 - 478 Jmol AstexViewer SPICE
2GH5 A 367 - 478 Jmol AstexViewer SPICE
B 367 - 478 Jmol AstexViewer SPICE
2GRT A 367 - 478 Jmol AstexViewer SPICE
3DJG X 367 - 478 Jmol AstexViewer SPICE
3DJJ A 367 - 478 Jmol AstexViewer SPICE
3DK4 A 367 - 478 Jmol AstexViewer SPICE
3DK8 A 367 - 478 Jmol AstexViewer SPICE
3DK9 A 367 - 478 Jmol AstexViewer SPICE
3GRS A 367 - 478 Jmol AstexViewer SPICE
3GRT A 367 - 478 Jmol AstexViewer SPICE
3SQP A 367 - 478 Jmol AstexViewer SPICE
B 367 - 478 Jmol AstexViewer SPICE
4GR1 A 367 - 478 Jmol AstexViewer SPICE
4GRT A 367 - 478 Jmol AstexViewer SPICE
5GRT A 367 - 478 Jmol AstexViewer SPICE
480 - 503 1ALG A 1 - 24 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.