Summary
This is the summary of UniProt entry GSHR_HUMAN (P00390).
| Description: | Glutathione reductase, mitochondrial EC=1.8.1.7 |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
View Pfam proteome data. |
| Length: | 522 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| low_complexity | n/a | 17 | 30 |
| disorder | n/a | 41 | 42 |
| disorder | n/a | 45 | 55 |
| low_complexity | n/a | 50 | 61 |
| Pfam A | Pyr_redox_2 | 66 | 380 |
| low_complexity | n/a | 71 | 94 |
| disorder | n/a | 202 | 204 |
| disorder | n/a | 209 | 212 |
| Pfam A | Pyr_redox | 233 | 312 |
| Pfam A | Pyr_redox_dim | 411 | 522 |
| disorder | n/a | 521 | 522 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession P00390. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MALLPRALSA GAGPSWRRAA RAFRGFLLLL PEPAALTRAL SRAMACRQEP
50 51
QPQGPPPAAG AVASYDYLVI GGGSGGLASA RRAAELGARA AVVESHKLGG
100 101
TCVNVGCVPK KVMWNTAVHS EFMHDHADYG FPSCEGKFNW RVIKEKRDAY
150 151
VSRLNAIYQN NLTKSHIEII RGHAAFTSDP KPTIEVSGKK YTAPHILIAT
200 201
GGMPSTPHES QIPGASLGIT SDGFFQLEEL PGRSVIVGAG YIAVEMAGIL
250 251
SALGSKTSLM IRHDKVLRSF DSMISTNCTE ELENAGVEVL KFSQVKEVKK
300 301
TLSGLEVSMV TAVPGRLPVM TMIPDVDCLL WAIGRVPNTK DLSLNKLGIQ
350 351
TDDKGHIIVD EFQNTNVKGI YAVGDVCGKA LLTPVAIAAG RKLAHRLFEY
400 401
KEDSKLDYNN IPTVVFSHPP IGTVGLTEDE AIHKYGIENV KTYSTSFTPM
450 451
YHAVTKRKTK CVMKMVCANK EEKVVGIHMQ GLGCDEMLQG FAVAVKMGAT
500 501
KADFDNTVAI HPTSSEELVT LR
522
Show the unformatted sequence. |
| Checksums: |
CRC64:DD8E2BA9D6E3757B
MD5:092d76e9bc45a52e22adc12123c79581
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.