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52  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: EGFR_HUMAN (P00533)

Summary

This is the summary of UniProt entry EGFR_HUMAN (P00533).

Description: Epidermal growth factor receptor EC=2.7.10.1
Source organism: Homo sapiens (Human)
Length: 1210 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
sig_p n/a 1 24
low_complexity n/a 7 25
Pfam A Recep_L_domain 57 168
Pfam A Furin-like 177 338
Pfam A Recep_L_domain 361 481
Pfam A GF_recep_IV 505 637
transmembrane n/a 646 667
low_complexity n/a 651 666
low_complexity n/a 675 692
Pfam A Pkinase_Tyr 712 968
disorder n/a 983 985
low_complexity n/a 1002 1015
low_complexity n/a 1025 1046
disorder n/a 1034 1037
disorder n/a 1061 1064
disorder n/a 1068 1085
disorder n/a 1087 1139
disorder n/a 1143 1145
disorder n/a 1150 1154
disorder n/a 1157 1185
disorder n/a 1187 1195
disorder n/a 1198 1201

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P00533. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MRPSGTAGAA LLALLAALCP ASRALEEKKV CQGTSNKLTQ LGTFEDHFLS
50
51
LQRMFNNCEV VLGNLEITYV QRNYDLSFLK TIQEVAGYVL IALNTVERIP
100
101
LENLQIIRGN MYYENSYALA VLSNYDANKT GLKELPMRNL QEILHGAVRF
150
151
SNNPALCNVE SIQWRDIVSS DFLSNMSMDF QNHLGSCQKC DPSCPNGSCW
200
201
GAGEENCQKL TKIICAQQCS GRCRGKSPSD CCHNQCAAGC TGPRESDCLV
250
251
CRKFRDEATC KDTCPPLMLY NPTTYQMDVN PEGKYSFGAT CVKKCPRNYV
300
301
VTDHGSCVRA CGADSYEMEE DGVRKCKKCE GPCRKVCNGI GIGEFKDSLS
350
351
INATNIKHFK NCTSISGDLH ILPVAFRGDS FTHTPPLDPQ ELDILKTVKE
400
401
ITGFLLIQAW PENRTDLHAF ENLEIIRGRT KQHGQFSLAV VSLNITSLGL
450
451
RSLKEISDGD VIISGNKNLC YANTINWKKL FGTSGQKTKI ISNRGENSCK
500
501
ATGQVCHALC SPEGCWGPEP RDCVSCRNVS RGRECVDKCN LLEGEPREFV
550
551
ENSECIQCHP ECLPQAMNIT CTGRGPDNCI QCAHYIDGPH CVKTCPAGVM
600
601
GENNTLVWKY ADAGHVCHLC HPNCTYGCTG PGLEGCPTNG PKIPSIATGM
650
651
VGALLLLLVV ALGIGLFMRR RHIVRKRTLR RLLQERELVE PLTPSGEAPN
700
701
QALLRILKET EFKKIKVLGS GAFGTVYKGL WIPEGEKVKI PVAIKELREA
750
751
TSPKANKEIL DEAYVMASVD NPHVCRLLGI CLTSTVQLIT QLMPFGCLLD
800
801
YVREHKDNIG SQYLLNWCVQ IAKGMNYLED RRLVHRDLAA RNVLVKTPQH
850
851
VKITDFGLAK LLGAEEKEYH AEGGKVPIKW MALESILHRI YTHQSDVWSY
900
901
GVTVWELMTF GSKPYDGIPA SEISSILEKG ERLPQPPICT IDVYMIMVKC
950
951
WMIDADSRPK FRELIIEFSK MARDPQRYLV IQGDERMHLP SPTDSNFYRA
1000
1001
LMDEEDMDDV VDADEYLIPQ QGFFSSPSTS RTPLLSSLSA TSNNSTVACI
1050
1051
DRNGLQSCPI KEDSFLQRYS SDPTGALTED SIDDTFLPVP EYINQSVPKR
1100
1101
PAGSVQNPVY HNQPLNPAPS RDPHYQDPHS TAVGNPEYLN TVQPTCVNST
1150
1151
FDSPAHWAQK GSHQISLDNP DYQQDFFPKE AKPNGIFKGS TAENAEYLRV
1200
1201
APQSSEFIGA                                            
1210
 

Show the unformatted sequence.

Checksums:
CRC64:D8A2A50B4EFB6ED2
MD5:99d03b567dbcdd7fb0dd21fb40d5d283

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Furin-like 177 - 338 1IVO A 153 - 314 Jmol AstexViewer SPICE
B 153 - 314 Jmol AstexViewer SPICE
1MOX A 153 - 314 Jmol AstexViewer SPICE
B 153 - 314 Jmol AstexViewer SPICE
1NQL A 153 - 314 Jmol AstexViewer SPICE
1YY9 A 153 - 314 Jmol AstexViewer SPICE
3NJP A 153 - 314 Jmol AstexViewer SPICE
B 153 - 314 Jmol AstexViewer SPICE
3QWQ A 153 - 314 Jmol AstexViewer SPICE
263 - 338 3B2V A 239 - 314 Jmol AstexViewer SPICE
311 - 326 3G5V C 287 - 302 Jmol AstexViewer SPICE
3G5Y E 287 - 302 Jmol AstexViewer SPICE
334 - 338 3P0Y A 310 - 314 Jmol AstexViewer SPICE
335 - 338 3B2U A 311 - 314 Jmol AstexViewer SPICE
B 311 - 314 Jmol AstexViewer SPICE
E 311 - 314 Jmol AstexViewer SPICE
I 311 - 314 Jmol AstexViewer SPICE
M 311 - 314 Jmol AstexViewer SPICE
P 311 - 314 Jmol AstexViewer SPICE
S 311 - 314 Jmol AstexViewer SPICE
V 311 - 314 Jmol AstexViewer SPICE
3C09 A 311 - 314 Jmol AstexViewer SPICE
D 311 - 314 Jmol AstexViewer SPICE
GF_recep_IV 505 - 524 1MOX A 481 - 500 Jmol AstexViewer SPICE
3C09 A 481 - 500 Jmol AstexViewer SPICE
D 481 - 500 Jmol AstexViewer SPICE
505 - 525 1MOX B 481 - 501 Jmol AstexViewer SPICE
505 - 526 3B2U A 481 - 502 Jmol AstexViewer SPICE
B 481 - 502 Jmol AstexViewer SPICE
E 481 - 502 Jmol AstexViewer SPICE
I 481 - 502 Jmol AstexViewer SPICE
M 481 - 502 Jmol AstexViewer SPICE
P 481 - 502 Jmol AstexViewer SPICE
S 481 - 502 Jmol AstexViewer SPICE
V 481 - 502 Jmol AstexViewer SPICE
505 - 527 3P0Y A 481 - 503 Jmol AstexViewer SPICE
505 - 536 1IVO A 481 - 512 Jmol AstexViewer SPICE
B 481 - 512 Jmol AstexViewer SPICE
505 - 637 1NQL A 481 - 613 Jmol AstexViewer SPICE
1YY9 A 481 - 613 Jmol AstexViewer SPICE
3B2V A 481 - 613 Jmol AstexViewer SPICE
3NJP A 481 - 613 Jmol AstexViewer SPICE
B 481 - 613 Jmol AstexViewer SPICE
3QWQ A 481 - 613 Jmol AstexViewer SPICE
Pkinase_Tyr 712 - 721 1Z9I A 44 - 53 Jmol AstexViewer SPICE
712 - 968 1M14 A 688 - 944 Jmol AstexViewer SPICE
1M17 A 688 - 944 Jmol AstexViewer SPICE
1XKK A 712 - 968 Jmol AstexViewer SPICE
2EB2 A 712 - 968 Jmol AstexViewer SPICE
2EB3 A 712 - 968 Jmol AstexViewer SPICE
2GS2 A 688 - 944 Jmol AstexViewer SPICE
2GS6 A 688 - 944 Jmol AstexViewer SPICE
2GS7 A 688 - 944 Jmol AstexViewer SPICE
B 688 - 944 Jmol AstexViewer SPICE
2ITN A 712 - 968 Jmol AstexViewer SPICE
2ITO A 712 - 968 Jmol AstexViewer SPICE
2ITP A 712 - 968 Jmol AstexViewer SPICE
2ITQ A 712 - 968 Jmol AstexViewer SPICE
2ITT A 712 - 968 Jmol AstexViewer SPICE
2ITU A 712 - 968 Jmol AstexViewer SPICE
2ITV A 712 - 968 Jmol AstexViewer SPICE
2ITW A 712 - 968 Jmol AstexViewer SPICE
2ITX A 712 - 968 Jmol AstexViewer SPICE
2ITY A 712 - 968 Jmol AstexViewer SPICE
2ITZ A 712 - 968 Jmol AstexViewer SPICE
2J5E A 712 - 968 Jmol AstexViewer SPICE
2J5F A 712 - 968 Jmol AstexViewer SPICE
2J6M A 712 - 968 Jmol AstexViewer SPICE
2JIT A 712 - 968 Jmol AstexViewer SPICE
B 712 - 968 Jmol AstexViewer SPICE
2JIU A 712 - 968 Jmol AstexViewer SPICE
B 712 - 968 Jmol AstexViewer SPICE
2JIV A 712 - 968 Jmol AstexViewer SPICE
B 712 - 968 Jmol AstexViewer SPICE
2RF9 A 688 - 944 Jmol AstexViewer SPICE
B 688 - 944 Jmol AstexViewer SPICE
2RFD A 688 - 944 Jmol AstexViewer SPICE
B 688 - 944 Jmol AstexViewer SPICE
2RFE A 688 - 944 Jmol AstexViewer SPICE
B 688 - 944 Jmol AstexViewer SPICE
C 688 - 944 Jmol AstexViewer SPICE
D 688 - 944 Jmol AstexViewer SPICE
2RGP A 712 - 968 Jmol AstexViewer SPICE
3BEL A 712 - 968 Jmol AstexViewer SPICE
3GOP A 688 - 944 Jmol AstexViewer SPICE
3GT8 A 688 - 944 Jmol AstexViewer SPICE
B 688 - 944 Jmol AstexViewer SPICE
C 688 - 944 Jmol AstexViewer SPICE
D 688 - 944 Jmol AstexViewer SPICE
3IKA A 712 - 968 Jmol AstexViewer SPICE
B 712 - 968 Jmol AstexViewer SPICE
3LZB A 688 - 944 Jmol AstexViewer SPICE
B 688 - 944 Jmol AstexViewer SPICE
C 688 - 944 Jmol AstexViewer SPICE
D 688 - 944 Jmol AstexViewer SPICE
3POZ A 712 - 968 Jmol AstexViewer SPICE
3UG1 A 712 - 968 Jmol AstexViewer SPICE
3UG2 A 712 - 968 Jmol AstexViewer SPICE
3VJN A 712 - 968 Jmol AstexViewer SPICE
3VJO A 712 - 968 Jmol AstexViewer SPICE
Recep_L_domain 361 - 481 1IVO A 337 - 457 Jmol AstexViewer SPICE
B 337 - 457 Jmol AstexViewer SPICE
1MOX A 337 - 457 Jmol AstexViewer SPICE
B 337 - 457 Jmol AstexViewer SPICE
1NQL A 337 - 457 Jmol AstexViewer SPICE
1YY9 A 337 - 457 Jmol AstexViewer SPICE
3B2U A 337 - 457 Jmol AstexViewer SPICE
B 337 - 457 Jmol AstexViewer SPICE
E 337 - 457 Jmol AstexViewer SPICE
I 337 - 457 Jmol AstexViewer SPICE
M 337 - 457 Jmol AstexViewer SPICE
P 337 - 457 Jmol AstexViewer SPICE
S 337 - 457 Jmol AstexViewer SPICE
V 337 - 457 Jmol AstexViewer SPICE
3B2V A 337 - 457 Jmol AstexViewer SPICE
3C09 A 337 - 457 Jmol AstexViewer SPICE
D 337 - 457 Jmol AstexViewer SPICE
3NJP A 337 - 457 Jmol AstexViewer SPICE
B 337 - 457 Jmol AstexViewer SPICE
3P0Y A 337 - 457 Jmol AstexViewer SPICE
3QWQ A 337 - 457 Jmol AstexViewer SPICE
57 - 168 1IVO A 33 - 144 Jmol AstexViewer SPICE
B 33 - 144 Jmol AstexViewer SPICE
1MOX A 33 - 144 Jmol AstexViewer SPICE
B 33 - 144 Jmol AstexViewer SPICE
1NQL A 33 - 144 Jmol AstexViewer SPICE
1YY9 A 33 - 144 Jmol AstexViewer SPICE
3NJP A 33 - 144 Jmol AstexViewer SPICE
B 33 - 144 Jmol AstexViewer SPICE
3QWQ A 33 - 144 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.