Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
15  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: LDLR_HUMAN (P01130)

Summary

This is the summary of UniProt entry LDLR_HUMAN (P01130).

Description: Low-density lipoprotein receptor
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 860 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
sig_p n/a 1 24
low_complexity n/a 11 24
Pfam A Ldl_recept_a 25 63
Pfam A Ldl_recept_a 66 104
Pfam A Ldl_recept_a 107 143
Pfam A Ldl_recept_a 146 184
Pfam A Ldl_recept_a 195 231
Pfam A Ldl_recept_a 234 270
Pfam A Ldl_recept_a 274 313
Pfam A Ldl_recept_b 439 483
Pfam A Ldl_recept_b 486 526
Pfam A Ldl_recept_b 529 570
Pfam A Ldl_recept_b 573 615
Pfam A Ldl_recept_b 616 656
Pfam A FXa_inhibition 671 711
low_complexity n/a 713 726
disorder n/a 730 734
disorder n/a 736 755
disorder n/a 775 780
transmembrane n/a 789 810
low_complexity n/a 797 809
Pfam B Pfam-B_2213 802 832

Show or hide domain scores.

Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

Note: it can take a few seconds for this image to be generated and loaded.

Loading feature alignment...

Show sources update panel.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P01130. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGPWGWKLRW TVALLLAAAG TAVGDRCERN EFQCQDGKCI SYKWVCDGSA
50
51
ECQDGSDESQ ETCLSVTCKS GDFSCGGRVN RCIPQFWRCD GQVDCDNGSD
100
101
EQGCPPKTCS QDEFRCHDGK CISRQFVCDS DRDCLDGSDE ASCPVLTCGP
150
151
ASFQCNSSTC IPQLWACDND PDCEDGSDEW PQRCRGLYVF QGDSSPCSAF
200
201
EFHCLSGECI HSSWRCDGGP DCKDKSDEEN CAVATCRPDE FQCSDGNCIH
250
251
GSRQCDREYD CKDMSDEVGC VNVTLCEGPN KFKCHSGECI TLDKVCNMAR
300
301
DCRDWSDEPI KECGTNECLD NNGGCSHVCN DLKIGYECLC PDGFQLVAQR
350
351
RCEDIDECQD PDTCSQLCVN LEGGYKCQCE EGFQLDPHTK ACKAVGSIAY
400
401
LFFTNRHEVR KMTLDRSEYT SLIPNLRNVV ALDTEVASNR IYWSDLSQRM
450
451
ICSTQLDRAH GVSSYDTVIS RDIQAPDGLA VDWIHSNIYW TDSVLGTVSV
500
501
ADTKGVKRKT LFRENGSKPR AIVVDPVHGF MYWTDWGTPA KIKKGGLNGV
550
551
DIYSLVTENI QWPNGITLDL LSGRLYWVDS KLHSISSIDV NGGNRKTILE
600
601
DEKRLAHPFS LAVFEDKVFW TDIINEAIFS ANRLTGSDVN LLAENLLSPE
650
651
DMVLFHNLTQ PRGVNWCERT TLSNGGCQYL CLPAPQINPH SPKFTCACPD
700
701
GMLLARDMRS CLTEAEAAVA TQETSTVRLK VSSTAVRTQH TTTRPVPDTS
750
751
RLPGATPGLT TVEIVTMSHQ ALGDVAGRGN EKKPSSVRAL SIVLPIVLLV
800
801
FLCLGVFLLW KNWRLKNINS INFDNPVYQK TTEDEVHICH NQDGYSYPSR
850
851
QMVSLEDDVA                                            
860
 

Show the unformatted sequence.

Checksums:
CRC64:A4C28E9B8BADAD5E
MD5:2fa95af0f24f46a4393b630463a5e94f

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
FXa_inhibition 671 - 711 1IJQ A 650 - 690 Jmol AstexViewer SPICE
B 650 - 690 Jmol AstexViewer SPICE
1N7D A 650 - 690 Jmol AstexViewer SPICE
3M0C C 650 - 690 Jmol AstexViewer SPICE
3P5B L 650 - 690 Jmol AstexViewer SPICE
3P5C L 650 - 690 Jmol AstexViewer SPICE
Ldl_recept_a 107 - 143 1N7D A 86 - 122 Jmol AstexViewer SPICE
2FCW B 86 - 122 Jmol AstexViewer SPICE
146 - 184 1N7D A 125 - 163 Jmol AstexViewer SPICE
2FCW B 125 - 163 Jmol AstexViewer SPICE
2LGP A 125 - 163 Jmol AstexViewer SPICE
147 - 184 2KRI B 126 - 163 Jmol AstexViewer SPICE
195 - 231 1N7D A 174 - 210 Jmol AstexViewer SPICE
2LGP A 174 - 210 Jmol AstexViewer SPICE
196 - 231 1AJJ A 4 - 39 Jmol AstexViewer SPICE
234 - 270 1D2J A 213 - 249 Jmol AstexViewer SPICE
1F8Z A 1 - 37 Jmol AstexViewer SPICE
1N7D A 213 - 249 Jmol AstexViewer SPICE
25 - 63 1F5Y A 6 - 44 Jmol AstexViewer SPICE
1LDL A 4 - 42 Jmol AstexViewer SPICE
274 - 313 1N7D A 253 - 292 Jmol AstexViewer SPICE
1XFE A 4 - 43 Jmol AstexViewer SPICE
276 - 313 3M0C C 255 - 292 Jmol AstexViewer SPICE
3P5C L 255 - 292 Jmol AstexViewer SPICE
66 - 104 1F5Y A 47 - 85 Jmol AstexViewer SPICE
1LDR A 3 - 41 Jmol AstexViewer SPICE
1N7D A 45 - 83 Jmol AstexViewer SPICE
Ldl_recept_b 439 - 483 1IJQ A 418 - 462 Jmol AstexViewer SPICE
B 418 - 462 Jmol AstexViewer SPICE
1N7D A 418 - 462 Jmol AstexViewer SPICE
3M0C C 418 - 462 Jmol AstexViewer SPICE
3P5B L 418 - 462 Jmol AstexViewer SPICE
3P5C L 418 - 462 Jmol AstexViewer SPICE
486 - 526 1IJQ A 465 - 505 Jmol AstexViewer SPICE
B 465 - 505 Jmol AstexViewer SPICE
1N7D A 465 - 505 Jmol AstexViewer SPICE
3M0C C 465 - 505 Jmol AstexViewer SPICE
3P5B L 465 - 505 Jmol AstexViewer SPICE
3P5C L 465 - 505 Jmol AstexViewer SPICE
529 - 570 1IJQ A 508 - 549 Jmol AstexViewer SPICE
B 508 - 549 Jmol AstexViewer SPICE
1N7D A 508 - 549 Jmol AstexViewer SPICE
3M0C C 508 - 549 Jmol AstexViewer SPICE
3P5B L 508 - 549 Jmol AstexViewer SPICE
3P5C L 508 - 549 Jmol AstexViewer SPICE
573 - 615 1IJQ A 552 - 594 Jmol AstexViewer SPICE
B 552 - 594 Jmol AstexViewer SPICE
1N7D A 552 - 594 Jmol AstexViewer SPICE
3M0C C 552 - 594 Jmol AstexViewer SPICE
3P5B L 552 - 594 Jmol AstexViewer SPICE
3P5C L 552 - 594 Jmol AstexViewer SPICE
616 - 656 1IJQ A 595 - 635 Jmol AstexViewer SPICE
B 595 - 635 Jmol AstexViewer SPICE
1N7D A 595 - 635 Jmol AstexViewer SPICE
3M0C C 595 - 635 Jmol AstexViewer SPICE
3P5B L 595 - 635 Jmol AstexViewer SPICE
3P5C L 595 - 635 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.