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12  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TNFA_HUMAN (P01375)

Summary

This is the summary of UniProt entry TNFA_HUMAN (P01375).

Description: Tumor necrosis factor
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 233 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
disorder n/a 13 19
transmembrane n/a 30 55
low_complexity n/a 31 39
disorder n/a 85 92
Pfam A TNF 102 233

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P01375. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSTESMIRDV ELAEEALPKK TGGPQGSRRC LFLSLFSFLI VAGATTLFCL
50
51
LHFGVIGPQR EEFPRDLSLI SPLAQAVRSS SRTPSDKPVA HVVANPQAEG
100
101
QLQWLNRRAN ALLANGVELR DNQLVVPSEG LYLIYSQVLF KGQGCPSTHV
150
151
LLTHTISRIA VSYQTKVNLL SAIKSPCQRE TPEGAEAKPW YEPIYLGGVF
200
201
QLEKGDRLSA EINRPDYLDF AESGQVYFGI IAL                  
233
 

Show the unformatted sequence.

Checksums:
CRC64:3DF90F96C9031FFE
MD5:60ada54e69e411bcf6b08e9dacff7a48

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
TNF 102 - 233 1A8M A 26 - 157 Jmol AstexViewer SPICE
B 26 - 157 Jmol AstexViewer SPICE
C 26 - 157 Jmol AstexViewer SPICE
1TNF A 26 - 157 Jmol AstexViewer SPICE
B 26 - 157 Jmol AstexViewer SPICE
C 26 - 157 Jmol AstexViewer SPICE
2AZ5 A 26 - 157 Jmol AstexViewer SPICE
B 26 - 157 Jmol AstexViewer SPICE
C 26 - 157 Jmol AstexViewer SPICE
D 26 - 157 Jmol AstexViewer SPICE
2E7A A 26 - 157 Jmol AstexViewer SPICE
B 26 - 157 Jmol AstexViewer SPICE
C 26 - 157 Jmol AstexViewer SPICE
2TUN A 26 - 157 Jmol AstexViewer SPICE
B 26 - 157 Jmol AstexViewer SPICE
C 26 - 157 Jmol AstexViewer SPICE
D 26 - 157 Jmol AstexViewer SPICE
E 26 - 157 Jmol AstexViewer SPICE
F 26 - 157 Jmol AstexViewer SPICE
2ZJC A 26 - 157 Jmol AstexViewer SPICE
B 26 - 157 Jmol AstexViewer SPICE
C 26 - 157 Jmol AstexViewer SPICE
2ZPX A 26 - 157 Jmol AstexViewer SPICE
B 26 - 157 Jmol AstexViewer SPICE
C 26 - 157 Jmol AstexViewer SPICE
3ALQ A 26 - 157 Jmol AstexViewer SPICE
B 26 - 157 Jmol AstexViewer SPICE
C 26 - 157 Jmol AstexViewer SPICE
D 26 - 157 Jmol AstexViewer SPICE
E 26 - 157 Jmol AstexViewer SPICE
F 26 - 157 Jmol AstexViewer SPICE
3IT8 A 26 - 157 Jmol AstexViewer SPICE
B 26 - 157 Jmol AstexViewer SPICE
C 26 - 157 Jmol AstexViewer SPICE
G 26 - 157 Jmol AstexViewer SPICE
H 26 - 157 Jmol AstexViewer SPICE
I 26 - 157 Jmol AstexViewer SPICE
3L9J T 26 - 157 Jmol AstexViewer SPICE
4TSV A 26 - 157 Jmol AstexViewer SPICE
5TSW A 26 - 157 Jmol AstexViewer SPICE
B 26 - 157 Jmol AstexViewer SPICE
C 26 - 157 Jmol AstexViewer SPICE
D 26 - 157 Jmol AstexViewer SPICE
E 26 - 157 Jmol AstexViewer SPICE
F 26 - 157 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.