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5  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: IL2RA_HUMAN (P01589)

Summary

This is the summary of UniProt entry IL2RA_HUMAN (P01589).

Description: Interleukin-2 receptor subunit alpha
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 272 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
sig_p n/a 1 21
Pfam A Sushi 24 82
disorder n/a 35 37
disorder n/a 87 132
Pfam A Sushi 125 184
disorder n/a 136 137
disorder n/a 169 171
disorder n/a 179 181
disorder n/a 185 214
Pfam B Pfam-B_20370 197 242
transmembrane n/a 239 261
low_complexity n/a 249 259

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P01589. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MDSYLLMWGL LTFIMVPGCQ AELCDDDPPE IPHATFKAMA YKEGTMLNCE
50
51
CKRGFRRIKS GSLYMLCTGN SSHSSWDNQC QCTSSATRNT TKQVTPQPEE
100
101
QKERKTTEMQ SPMQPVDQAS LPGHCREPPP WENEATERIY HFVVGQMVYY
150
151
QCVQGYRALH RGPAESVCKM THGKTRWTQP QLICTGEMET SQFPGEEKPQ
200
201
ASPEGRPESE TSCLVTTTDF QIQTEMAATM ETSIFTTEYQ VAVAGCVFLL
250
251
ISVLLLSGLT WQRRQRKSRR TI                              
272
 

Show the unformatted sequence.

Checksums:
CRC64:83D907C8C81D2C0E
MD5:723e6a9f9f8cfdcc65f91030b8b08423

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Sushi 125 - 177 3IU3 K 104 - 156 Jmol AstexViewer SPICE
125 - 179 3IU3 I 104 - 158 Jmol AstexViewer SPICE
J 104 - 158 Jmol AstexViewer SPICE
125 - 182 3NFP K 104 - 161 Jmol AstexViewer SPICE
125 - 184 1Z92 B 104 - 163 Jmol AstexViewer SPICE
2B5I D 104 - 163 Jmol AstexViewer SPICE
2ERJ A 104 - 163 Jmol AstexViewer SPICE
E 104 - 163 Jmol AstexViewer SPICE
3NFP I 104 - 163 Jmol AstexViewer SPICE
24 - 82 1Z92 B 3 - 61 Jmol AstexViewer SPICE
2B5I D 3 - 61 Jmol AstexViewer SPICE
2ERJ A 3 - 61 Jmol AstexViewer SPICE
E 3 - 61 Jmol AstexViewer SPICE
3IU3 I 3 - 61 Jmol AstexViewer SPICE
J 3 - 61 Jmol AstexViewer SPICE
K 3 - 61 Jmol AstexViewer SPICE
3NFP I 3 - 61 Jmol AstexViewer SPICE
K 3 - 61 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.