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38  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CD4_HUMAN (P01730)

Summary

This is the summary of UniProt entry CD4_HUMAN (P01730).

Description: T-cell surface glycoprotein CD4
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 458 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
sig_p n/a 1 25
low_complexity n/a 10 22
Pfam A V-set 21 129
disorder n/a 72 75
disorder n/a 79 82
Pfam A C2-set 125 203
disorder n/a 147 159
Pfam A CD4-extracel 205 316
Pfam A C2-set 317 390
transmembrane n/a 397 420
low_complexity n/a 398 418
Pfam A Tcell_CD4_Cterm 426 453

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P01730. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MNRGVPFRHL LLVLQLALLP AATQGKKVVL GKKGDTVELT CTASQKKSIQ
50
51
FHWKNSNQIK ILGNQGSFLT KGPSKLNDRA DSRRSLWDQG NFPLIIKNLK
100
101
IEDSDTYICE VEDQKEEVQL LVFGLTANSD THLLQGQSLT LTLESPPGSS
150
151
PSVQCRSPRG KNIQGGKTLS VSQLELQDSG TWTCTVLQNQ KKVEFKIDIV
200
201
VLAFQKASSI VYKKEGEQVE FSFPLAFTVE KLTGSGELWW QAERASSSKS
250
251
WITFDLKNKE VSVKRVTQDP KLQMGKKLPL HLTLPQALPQ YAGSGNLTLA
300
301
LEAKTGKLHQ EVNLVVMRAT QLQKNLTCEV WGPTSPKLML SLKLENKEAK
350
351
VSKREKAVWV LNPEAGMWQC LLSDSGQVLL ESNIKVLPTW STPVQPMALI
400
401
VLGGVAGLLL FIGLGIFFCV RCRHRRRQAE RMSQIKRLLS EKKTCQCPHR
450
451
FQKTCSPI                                              
458
 

Show the unformatted sequence.

Checksums:
CRC64:20ED893F9E56D236
MD5:91ad571225fa48d4b2c4698eadd20e4a

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
C2-set 125 - 200 2B4C C 100 - 175 Jmol AstexViewer SPICE
125 - 201 3LQA C 100 - 176 Jmol AstexViewer SPICE
125 - 203 1CDH A 100 - 178 Jmol AstexViewer SPICE
1CDI A 100 - 178 Jmol AstexViewer SPICE
1CDJ A 100 - 178 Jmol AstexViewer SPICE
1CDU A 100 - 178 Jmol AstexViewer SPICE
1CDY A 100 - 178 Jmol AstexViewer SPICE
1G9M C 100 - 178 Jmol AstexViewer SPICE
1G9N C 100 - 178 Jmol AstexViewer SPICE
1GC1 C 100 - 178 Jmol AstexViewer SPICE
1JL4 D 100 - 178 Jmol AstexViewer SPICE
1RZJ C 100 - 178 Jmol AstexViewer SPICE
1RZK C 100 - 178 Jmol AstexViewer SPICE
1WIO A 100 - 178 Jmol AstexViewer SPICE
B 100 - 178 Jmol AstexViewer SPICE
1WIP A 100 - 178 Jmol AstexViewer SPICE
B 100 - 178 Jmol AstexViewer SPICE
1WIQ A 100 - 178 Jmol AstexViewer SPICE
B 100 - 178 Jmol AstexViewer SPICE
2NXY B 1100 - 1178 Jmol AstexViewer SPICE
2NXZ B 1100 - 1178 Jmol AstexViewer SPICE
2NY0 B 1100 - 1178 Jmol AstexViewer SPICE
2NY1 B 1100 - 1178 Jmol AstexViewer SPICE
2NY2 B 1100 - 1178 Jmol AstexViewer SPICE
2NY3 B 1100 - 1178 Jmol AstexViewer SPICE
2NY4 B 1100 - 1178 Jmol AstexViewer SPICE
2NY5 C 1100 - 1178 Jmol AstexViewer SPICE
2NY6 B 1100 - 1178 Jmol AstexViewer SPICE
2QAD B 100 - 178 Jmol AstexViewer SPICE
F 100 - 178 Jmol AstexViewer SPICE
3CD4 A 100 - 178 Jmol AstexViewer SPICE
3JWD C 1100 - 1178 Jmol AstexViewer SPICE
D 1100 - 1178 Jmol AstexViewer SPICE
3JWO C 1100 - 1178 Jmol AstexViewer SPICE
3O2D A 100 - 178 Jmol AstexViewer SPICE
3S4S G 100 - 178 Jmol AstexViewer SPICE
H 100 - 178 Jmol AstexViewer SPICE
3S5L G 100 - 178 Jmol AstexViewer SPICE
H 100 - 178 Jmol AstexViewer SPICE
3T0E E 100 - 178 Jmol AstexViewer SPICE
317 - 388 1WIO A 292 - 363 Jmol AstexViewer SPICE
B 292 - 363 Jmol AstexViewer SPICE
1WIP A 292 - 363 Jmol AstexViewer SPICE
B 292 - 363 Jmol AstexViewer SPICE
1WIQ A 292 - 363 Jmol AstexViewer SPICE
B 292 - 363 Jmol AstexViewer SPICE
3T0E E 292 - 363 Jmol AstexViewer SPICE
CD4-extracel 205 - 316 1WIO A 180 - 291 Jmol AstexViewer SPICE
B 180 - 291 Jmol AstexViewer SPICE
1WIP A 180 - 291 Jmol AstexViewer SPICE
B 180 - 291 Jmol AstexViewer SPICE
1WIQ A 180 - 291 Jmol AstexViewer SPICE
B 180 - 291 Jmol AstexViewer SPICE
3T0E E 180 - 291 Jmol AstexViewer SPICE
Tcell_CD4_Cterm 426 - 453 1Q68 A 401 - 428 Jmol AstexViewer SPICE
2KLU A 401 - 428 Jmol AstexViewer SPICE
431 - 441 3B71 D 406 - 416 Jmol AstexViewer SPICE
E 406 - 416 Jmol AstexViewer SPICE
432 - 440 2JKR P 2 - 10 Jmol AstexViewer SPICE
Q 2 - 10 Jmol AstexViewer SPICE
2JKT P 2 - 10 Jmol AstexViewer SPICE
Q 2 - 10 Jmol AstexViewer SPICE
433 - 441 3B71 F 408 - 416 Jmol AstexViewer SPICE
V-set 26 - 127 3S4S H 1 - 102 Jmol AstexViewer SPICE
26 - 129 1CDH A 1 - 104 Jmol AstexViewer SPICE
1CDI A 1 - 104 Jmol AstexViewer SPICE
1CDJ A 1 - 104 Jmol AstexViewer SPICE
1CDU A 1 - 104 Jmol AstexViewer SPICE
1CDY A 1 - 104 Jmol AstexViewer SPICE
1G9M C 1 - 104 Jmol AstexViewer SPICE
1G9N C 1 - 104 Jmol AstexViewer SPICE
1GC1 C 1 - 104 Jmol AstexViewer SPICE
1JL4 D 1 - 104 Jmol AstexViewer SPICE
1RZJ C 1 - 104 Jmol AstexViewer SPICE
1RZK C 1 - 104 Jmol AstexViewer SPICE
1WIO A 1 - 104 Jmol AstexViewer SPICE
B 1 - 104 Jmol AstexViewer SPICE
1WIP A 1 - 104 Jmol AstexViewer SPICE
B 1 - 104 Jmol AstexViewer SPICE
1WIQ A 1 - 104 Jmol AstexViewer SPICE
B 1 - 104 Jmol AstexViewer SPICE
2B4C C 1 - 104 Jmol AstexViewer SPICE
2NXY B 1001 - 1104 Jmol AstexViewer SPICE
2NXZ B 1001 - 1104 Jmol AstexViewer SPICE
2NY0 B 1001 - 1104 Jmol AstexViewer SPICE
2NY1 B 1001 - 1104 Jmol AstexViewer SPICE
2NY2 B 1001 - 1104 Jmol AstexViewer SPICE
2NY3 B 1001 - 1104 Jmol AstexViewer SPICE
2NY4 B 1001 - 1104 Jmol AstexViewer SPICE
2NY5 C 1001 - 1104 Jmol AstexViewer SPICE
2NY6 B 1001 - 1104 Jmol AstexViewer SPICE
2QAD B 1 - 104 Jmol AstexViewer SPICE
F 1 - 104 Jmol AstexViewer SPICE
3CD4 A 1 - 104 Jmol AstexViewer SPICE
3JWD C 1001 - 1104 Jmol AstexViewer SPICE
D 1001 - 1104 Jmol AstexViewer SPICE
3JWO C 1001 - 1104 Jmol AstexViewer SPICE
3O2D A 1 - 104 Jmol AstexViewer SPICE
3S4S G 1 - 104 Jmol AstexViewer SPICE
3S5L H 1 - 104 Jmol AstexViewer SPICE
3T0E E 1 - 104 Jmol AstexViewer SPICE
27 - 128 3S5L G 2 - 103 Jmol AstexViewer SPICE
27 - 129 3LQA C 2 - 104 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.