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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: CO2A1_HUMAN (P02458)

Summary

This is the summary of UniProt entry CO2A1_HUMAN (P02458).

Description: Collagen alpha-1(II) chain
Source organism: Homo sapiens (Human)
Length: 1487 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
sig_p n/a 1 25
low_complexity n/a 9 21
Pfam A VWC 34 89
disorder n/a 96 1286
low_complexity n/a 98 110
Pfam A Collagen 116 182
low_complexity n/a 117 135
low_complexity n/a 153 177
low_complexity n/a 197 271
Pfam A Collagen 199 260
Pfam A Collagen 237 317
low_complexity n/a 309 325
low_complexity n/a 330 382
Pfam A Collagen 360 437
low_complexity n/a 390 412
low_complexity n/a 416 451
Pfam A Collagen 429 498
low_complexity n/a 464 510
low_complexity n/a 579 600
low_complexity n/a 621 633
low_complexity n/a 636 687
low_complexity n/a 696 711
low_complexity n/a 729 753
Pfam A Collagen 732 808
low_complexity n/a 783 849
Pfam A Collagen 792 860
Pfam A Collagen 843 917
low_complexity n/a 854 885
low_complexity n/a 888 903
low_complexity n/a 906 930
low_complexity n/a 948 966
low_complexity n/a 1017 1032
low_complexity n/a 1038 1053
low_complexity n/a 1062 1081
low_complexity n/a 1137 1176
Pfam A Collagen 1158 1217
low_complexity n/a 1179 1192
low_complexity n/a 1197 1217
Pfam A COLFI 1269 1486
low_complexity n/a 1333 1345
disorder n/a 1335 1336

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P02458. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MIRLGAPQTL VLLTLLVAAV LRCQGQDVQE AGSCVQDGQR YNDKDVWKPE
50
51
PCRICVCDTG TVLCDDIICE DVKDCLSPEI PFGECCPICP TDLATASGQP
100
101
GPKGQKGEPG DIKDIVGPKG PPGPQGPAGE QGPRGDRGDK GEKGAPGPRG
150
151
RDGEPGTPGN PGPPGPPGPP GPPGLGGNFA AQMAGGFDEK AGGAQLGVMQ
200
201
GPMGPMGPRG PPGPAGAPGP QGFQGNPGEP GEPGVSGPMG PRGPPGPPGK
250
251
PGDDGEAGKP GKAGERGPPG PQGARGFPGT PGLPGVKGHR GYPGLDGAKG
300
301
EAGAPGVKGE SGSPGENGSP GPMGPRGLPG ERGRTGPAGA AGARGNDGQP
350
351
GPAGPPGPVG PAGGPGFPGA PGAKGEAGPT GARGPEGAQG PRGEPGTPGS
400
401
PGPAGASGNP GTDGIPGAKG SAGAPGIAGA PGFPGPRGPP GPQGATGPLG
450
451
PKGQTGEPGI AGFKGEQGPK GEPGPAGPQG APGPAGEEGK RGARGEPGGV
500
501
GPIGPPGERG APGNRGFPGQ DGLAGPKGAP GERGPSGLAG PKGANGDPGR
550
551
PGEPGLPGAR GLTGRPGDAG PQGKVGPSGA PGEDGRPGPP GPQGARGQPG
600
601
VMGFPGPKGA NGEPGKAGEK GLPGAPGLRG LPGKDGETGA AGPPGPAGPA
650
651
GERGEQGAPG PSGFQGLPGP PGPPGEGGKP GDQGVPGEAG APGLVGPRGE
700
701
RGFPGERGSP GAQGLQGPRG LPGTPGTDGP KGASGPAGPP GAQGPPGLQG
750
751
MPGERGAAGI AGPKGDRGDV GEKGPEGAPG KDGGRGLTGP IGPPGPAGAN
800
801
GEKGEVGPPG PAGSAGARGA PGERGETGPP GPAGFAGPPG ADGQPGAKGE
850
851
QGEAGQKGDA GAPGPQGPSG APGPQGPTGV TGPKGARGAQ GPPGATGFPG
900
901
AAGRVGPPGS NGNPGPPGPP GPSGKDGPKG ARGDSGPPGR AGEPGLQGPA
950
951
GPPGEKGEPG DDGPSGAEGP PGPQGLAGQR GIVGLPGQRG ERGFPGLPGP
1000
1001
SGEPGKQGAP GASGDRGPPG PVGPPGLTGP AGEPGREGSP GADGPPGRDG
1050
1051
AAGVKGDRGE TGAVGAPGAP GPPGSPGPAG PTGKQGDRGE AGAQGPMGPS
1100
1101
GPAGARGIQG PQGPRGDKGE AGEPGERGLK GHRGFTGLQG LPGPPGPSGD
1150
1151
QGASGPAGPS GPRGPPGPVG PSGKDGANGI PGPIGPPGPR GRSGETGPAG
1200
1201
PPGNPGPPGP PGPPGPGIDM SAFAGLGPRE KGPDPLQYMR ADQAAGGLRQ
1250
1251
HDAEVDATLK SLNNQIESIR SPEGSRKNPA RTCRDLKLCH PEWKSGDYWI
1300
1301
DPNQGCTLDA MKVFCNMETG ETCVYPNPAN VPKKNWWSSK SKEKKHIWFG
1350
1351
ETINGGFHFS YGDDNLAPNT ANVQMTFLRL LSTEGSQNIT YHCKNSIAYL
1400
1401
DEAAGNLKKA LLIQGSNDVE IRAEGNSRFT YTALKDGCTK HTGKWGKTVI
1450
1451
EYRSQKTSRL PIIDIAPMDI GGPEQEFGVD IGPVCFL              
1487
 

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Checksums:
CRC64:A8312503825BF0BB
MD5:79890c4bfb30697f52dbe88409cce3e0

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
VWC 34 - 89 1U5M A 10 - 65 Jmol AstexViewer SPICE