Summary
This is the summary of UniProt entry CO2A1_HUMAN (P02458).
| Description: | Collagen alpha-1(II) chain |
| Source organism: |
Homo sapiens (Human) |
| Length: | 1487 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| sig_p | n/a | 1 | 25 |
| low_complexity | n/a | 9 | 21 |
| Pfam A | VWC | 34 | 89 |
| disorder | n/a | 96 | 1286 |
| low_complexity | n/a | 98 | 110 |
| Pfam A | Collagen | 116 | 182 |
| low_complexity | n/a | 117 | 135 |
| low_complexity | n/a | 153 | 177 |
| low_complexity | n/a | 197 | 271 |
| Pfam A | Collagen | 199 | 260 |
| Pfam A | Collagen | 237 | 317 |
| low_complexity | n/a | 309 | 325 |
| low_complexity | n/a | 330 | 382 |
| Pfam A | Collagen | 360 | 437 |
| low_complexity | n/a | 390 | 412 |
| low_complexity | n/a | 416 | 451 |
| Pfam A | Collagen | 429 | 498 |
| low_complexity | n/a | 464 | 510 |
| low_complexity | n/a | 579 | 600 |
| low_complexity | n/a | 621 | 633 |
| low_complexity | n/a | 636 | 687 |
| low_complexity | n/a | 696 | 711 |
| low_complexity | n/a | 729 | 753 |
| Pfam A | Collagen | 732 | 808 |
| low_complexity | n/a | 783 | 849 |
| Pfam A | Collagen | 792 | 860 |
| Pfam A | Collagen | 843 | 917 |
| low_complexity | n/a | 854 | 885 |
| low_complexity | n/a | 888 | 903 |
| low_complexity | n/a | 906 | 930 |
| low_complexity | n/a | 948 | 966 |
| low_complexity | n/a | 1017 | 1032 |
| low_complexity | n/a | 1038 | 1053 |
| low_complexity | n/a | 1062 | 1081 |
| low_complexity | n/a | 1137 | 1176 |
| Pfam A | Collagen | 1158 | 1217 |
| low_complexity | n/a | 1179 | 1192 |
| low_complexity | n/a | 1197 | 1217 |
| Pfam A | COLFI | 1269 | 1486 |
| low_complexity | n/a | 1333 | 1345 |
| disorder | n/a | 1335 | 1336 |
Show or hide domain scores.
Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
Note: it can take a few seconds for this image to be generated and loaded.
Show sources update panel.
Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession P02458. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MIRLGAPQTL VLLTLLVAAV LRCQGQDVQE AGSCVQDGQR YNDKDVWKPE
50 51
PCRICVCDTG TVLCDDIICE DVKDCLSPEI PFGECCPICP TDLATASGQP
100 101
GPKGQKGEPG DIKDIVGPKG PPGPQGPAGE QGPRGDRGDK GEKGAPGPRG
150 151
RDGEPGTPGN PGPPGPPGPP GPPGLGGNFA AQMAGGFDEK AGGAQLGVMQ
200 201
GPMGPMGPRG PPGPAGAPGP QGFQGNPGEP GEPGVSGPMG PRGPPGPPGK
250 251
PGDDGEAGKP GKAGERGPPG PQGARGFPGT PGLPGVKGHR GYPGLDGAKG
300 301
EAGAPGVKGE SGSPGENGSP GPMGPRGLPG ERGRTGPAGA AGARGNDGQP
350 351
GPAGPPGPVG PAGGPGFPGA PGAKGEAGPT GARGPEGAQG PRGEPGTPGS
400 401
PGPAGASGNP GTDGIPGAKG SAGAPGIAGA PGFPGPRGPP GPQGATGPLG
450 451
PKGQTGEPGI AGFKGEQGPK GEPGPAGPQG APGPAGEEGK RGARGEPGGV
500 501
GPIGPPGERG APGNRGFPGQ DGLAGPKGAP GERGPSGLAG PKGANGDPGR
550 551
PGEPGLPGAR GLTGRPGDAG PQGKVGPSGA PGEDGRPGPP GPQGARGQPG
600 601
VMGFPGPKGA NGEPGKAGEK GLPGAPGLRG LPGKDGETGA AGPPGPAGPA
650 651
GERGEQGAPG PSGFQGLPGP PGPPGEGGKP GDQGVPGEAG APGLVGPRGE
700 701
RGFPGERGSP GAQGLQGPRG LPGTPGTDGP KGASGPAGPP GAQGPPGLQG
750 751
MPGERGAAGI AGPKGDRGDV GEKGPEGAPG KDGGRGLTGP IGPPGPAGAN
800 801
GEKGEVGPPG PAGSAGARGA PGERGETGPP GPAGFAGPPG ADGQPGAKGE
850 851
QGEAGQKGDA GAPGPQGPSG APGPQGPTGV TGPKGARGAQ GPPGATGFPG
900 901
AAGRVGPPGS NGNPGPPGPP GPSGKDGPKG ARGDSGPPGR AGEPGLQGPA
950 951
GPPGEKGEPG DDGPSGAEGP PGPQGLAGQR GIVGLPGQRG ERGFPGLPGP
1000 1001
SGEPGKQGAP GASGDRGPPG PVGPPGLTGP AGEPGREGSP GADGPPGRDG
1050 1051
AAGVKGDRGE TGAVGAPGAP GPPGSPGPAG PTGKQGDRGE AGAQGPMGPS
1100 1101
GPAGARGIQG PQGPRGDKGE AGEPGERGLK GHRGFTGLQG LPGPPGPSGD
1150 1151
QGASGPAGPS GPRGPPGPVG PSGKDGANGI PGPIGPPGPR GRSGETGPAG
1200 1201
PPGNPGPPGP PGPPGPGIDM SAFAGLGPRE KGPDPLQYMR ADQAAGGLRQ
1250 1251
HDAEVDATLK SLNNQIESIR SPEGSRKNPA RTCRDLKLCH PEWKSGDYWI
1300 1301
DPNQGCTLDA MKVFCNMETG ETCVYPNPAN VPKKNWWSSK SKEKKHIWFG
1350 1351
ETINGGFHFS YGDDNLAPNT ANVQMTFLRL LSTEGSQNIT YHCKNSIAYL
1400 1401
DEAAGNLKKA LLIQGSNDVE IRAEGNSRFT YTALKDGCTK HTGKWGKTVI
1450 1451
EYRSQKTSRL PIIDIAPMDI GGPEQEFGVD IGPVCFL
1487
Show the unformatted sequence. |
| Checksums: |
CRC64:A8312503825BF0BB
MD5:79890c4bfb30697f52dbe88409cce3e0
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| VWC | 34 - 89 | 1U5M | A | 10 - 65 | Jmol AstexViewer SPICE |