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8  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: RAF1_HUMAN (P04049)

Summary

This is the summary of UniProt entry RAF1_HUMAN (P04049).

Description: RAF proto-oncogene serine/threonine-protein kinase EC=2.7.11.1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 648 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
disorder n/a 44 49
Pfam A RBD 56 131
Pfam A C1_1 139 187
disorder n/a 207 209
disorder n/a 212 228
disorder n/a 232 334
low_complexity n/a 283 301
Pfam A Pkinase_Tyr 349 606
disorder n/a 620 622

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P04049. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MEHIQGAWKT ISNGFGFKDA VFDGSSCISP TIVQQFGYQR RASDDGKLTD
50
51
PSKTSNTIRV FLPNKQRTVV NVRNGMSLHD CLMKALKVRG LQPECCAVFR
100
101
LLHEHKGKKA RLDWNTDAAS LIGEELQVDF LDHVPLTTHN FARKTFLKLA
150
151
FCDICQKFLL NGFRCQTCGY KFHEHCSTKV PTMCVDWSNI RQLLLFPNST
200
201
IGDSGVPALP SLTMRRMRES VSRMPVSSQH RYSTPHAFTF NTSSPSSEGS
250
251
LSQRQRSTST PNVHMVSTTL PVDSRMIEDA IRSHSESASP SALSSSPNNL
300
301
SPTGWSQPKT PVPAQRERAP VSGTQEKNKI RPRGQRDSSY YWEIEASEVM
350
351
LSTRIGSGSF GTVYKGKWHG DVAVKILKVV DPTPEQFQAF RNEVAVLRKT
400
401
RHVNILLFMG YMTKDNLAIV TQWCEGSSLY KHLHVQETKF QMFQLIDIAR
450
451
QTAQGMDYLH AKNIIHRDMK SNNIFLHEGL TVKIGDFGLA TVKSRWSGSQ
500
501
QVEQPTGSVL WMAPEVIRMQ DNNPFSFQSD VYSYGIVLYE LMTGELPYSH
550
551
INNRDQIIFM VGRGYASPDL SKLYKNCPKA MKRLVADCVK KVKEERPLFP
600
601
QILSSIELLQ HSLPKINRSA SEPSLHRAAH TEDINACTLT TSPRLPVF  
648
 

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Checksums:
CRC64:EF821B5349711BC3
MD5:d231d020cb5d921e3a7c5bbe10089245

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
C1_1 139 - 187 1FAQ A 139 - 187 Jmol AstexViewer SPICE
1FAR A 139 - 187 Jmol AstexViewer SPICE
Pkinase_Tyr 349 - 606 3OMV A 349 - 606 Jmol AstexViewer SPICE
B 349 - 606 Jmol AstexViewer SPICE
RBD 56 - 131 1C1Y B 56 - 131 Jmol AstexViewer SPICE
1GUA B 56 - 131 Jmol AstexViewer SPICE
1RFA A 56 - 131 Jmol AstexViewer SPICE
3KUC B 56 - 131 Jmol AstexViewer SPICE
3KUD B 56 - 131 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.