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22  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: GLCM_HUMAN (P04062)

Summary

This is the summary of UniProt entry GLCM_HUMAN (P04062).

Description: Glucosylceramidase EC=3.2.1.45
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 536 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
sig_p n/a 1 39
Pfam A Glyco_hydro_30 40 533
disorder n/a 90 92
low_complexity n/a 316 327

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P04062. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MEFSSPSREE CPKPLSRVSI MAGSLTGLLL LQAVSWASGA RPCIPKSFGY
50
51
SSVVCVCNAT YCDSFDPPTF PALGTFSRYE STRSGRRMEL SMGPIQANHT
100
101
GTGLLLTLQP EQKFQKVKGF GGAMTDAAAL NILALSPPAQ NLLLKSYFSE
150
151
EGIGYNIIRV PMASCDFSIR TYTYADTPDD FQLHNFSLPE EDTKLKIPLI
200
201
HRALQLAQRP VSLLASPWTS PTWLKTNGAV NGKGSLKGQP GDIYHQTWAR
250
251
YFVKFLDAYA EHKLQFWAVT AENEPSAGLL SGYPFQCLGF TPEHQRDFIA
300
301
RDLGPTLANS THHNVRLLML DDQRLLLPHW AKVVLTDPEA AKYVHGIAVH
350
351
WYLDFLAPAK ATLGETHRLF PNTMLFASEA CVGSKFWEQS VRLGSWDRGM
400
401
QYSHSIITNL LYHVVGWTDW NLALNPEGGP NWVRNFVDSP IIVDITKDTF
450
451
YKQPMFYHLG HFSKFIPEGS QRVGLVASQK NDLDAVALMH PDGSAVVVVL
500
501
NRSSKDVPLT IKDPAVGFLE TISPGYSIHT YLWRRQ               
536
 

Show the unformatted sequence.

Checksums:
CRC64:FA1E15684344A0E6
MD5:12025762cb73a22fb22d75ab63d2ead5

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Glyco_hydro_30 40 - 533 1OGS A 1 - 494 Jmol AstexViewer SPICE
B 1 - 494 Jmol AstexViewer SPICE
1Y7V A 1 - 494 Jmol AstexViewer SPICE
B 1 - 494 Jmol AstexViewer SPICE
2F61 A 1 - 494 Jmol AstexViewer SPICE
B 1 - 494 Jmol AstexViewer SPICE
2J25 A 1 - 494 Jmol AstexViewer SPICE
B 1 - 494 Jmol AstexViewer SPICE
2NSX A 1 - 494 Jmol AstexViewer SPICE
B 1 - 494 Jmol AstexViewer SPICE
C 1 - 494 Jmol AstexViewer SPICE
D 1 - 494 Jmol AstexViewer SPICE
2NT0 A 1 - 494 Jmol AstexViewer SPICE
B 1 - 494 Jmol AstexViewer SPICE
C 1 - 494 Jmol AstexViewer SPICE
D 1 - 494 Jmol AstexViewer SPICE
2NT1 A 1 - 494 Jmol AstexViewer SPICE
B 1 - 494 Jmol AstexViewer SPICE
C 1 - 494 Jmol AstexViewer SPICE
D 1 - 494 Jmol AstexViewer SPICE
2V3D A 1 - 494 Jmol AstexViewer SPICE
B 1 - 494 Jmol AstexViewer SPICE
2V3E A 1 - 494 Jmol AstexViewer SPICE
B 1 - 494 Jmol AstexViewer SPICE
2V3F A 1 - 494 Jmol AstexViewer SPICE
B 1 - 494 Jmol AstexViewer SPICE
2WCG A 1 - 494 Jmol AstexViewer SPICE
B 1 - 494 Jmol AstexViewer SPICE
2WKL A 1 - 494 Jmol AstexViewer SPICE
B 1 - 494 Jmol AstexViewer SPICE
2XWD A 1 - 494 Jmol AstexViewer SPICE
B 1 - 494 Jmol AstexViewer SPICE
2XWE A 1 - 494 Jmol AstexViewer SPICE
B 1 - 494 Jmol AstexViewer SPICE
3GXD A 1 - 494 Jmol AstexViewer SPICE
B 1 - 494 Jmol AstexViewer SPICE
C 1 - 494 Jmol AstexViewer SPICE
D 1 - 494 Jmol AstexViewer SPICE
3GXF A 1 - 494 Jmol AstexViewer SPICE
B 1 - 494 Jmol AstexViewer SPICE
C 1 - 494 Jmol AstexViewer SPICE
D 1 - 494 Jmol AstexViewer SPICE
3GXI A 1 - 494 Jmol AstexViewer SPICE
B 1 - 494 Jmol AstexViewer SPICE
C 1 - 494 Jmol AstexViewer SPICE
D 1 - 494 Jmol AstexViewer SPICE
3GXM A 1 - 494 Jmol AstexViewer SPICE
B 1 - 494 Jmol AstexViewer SPICE
C 1 - 494 Jmol AstexViewer SPICE
D 1 - 494 Jmol AstexViewer SPICE
3KE0 A 1 - 494 Jmol AstexViewer SPICE
B 1 - 494 Jmol AstexViewer SPICE
3KEH A 1 - 494 Jmol AstexViewer SPICE
B 1 - 494 Jmol AstexViewer SPICE
3RIK A 1 - 494 Jmol AstexViewer SPICE
B 1 - 494 Jmol AstexViewer SPICE
C 1 - 494 Jmol AstexViewer SPICE
D 1 - 494 Jmol AstexViewer SPICE
3RIL A 1 - 494 Jmol AstexViewer SPICE
B 1 - 494 Jmol AstexViewer SPICE
C 1 - 494 Jmol AstexViewer SPICE
D 1 - 494 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.