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10  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: HG2A_HUMAN (P04233)

Summary

This is the summary of UniProt entry HG2A_HUMAN (P04233).

Description: HLA class II histocompatibility antigen gamma chain
Source organism: Homo sapiens (Human)
Length: 296 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
disorder n/a 1 41
Pfam A MHC2-interact 17 129
transmembrane n/a 48 72
disorder n/a 83 84
disorder n/a 89 106
disorder n/a 108 110
disorder n/a 121 122
disorder n/a 125 134
Pfam A MHCassoc_trimer 136 207
disorder n/a 200 212
Pfam A Thyroglobulin_1 207 271
disorder n/a 214 216
disorder n/a 224 226
disorder n/a 263 274
disorder n/a 282 296

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P04233. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MHRRRSRSCR EDQKPVMDDQ RDLISNNEQL PMLGRRPGAP ESKCSRGALY
50
51
TGFSILVTLL LAGQATTAYF LYQQQGRLDK LTVTSQNLQL ENLRMKLPKP
100
101
PKPVSKMRMA TPLLMQALPM GALPQGPMQN ATKYGNMTED HVMHLLQNAD
150
151
PLKVYPPLKG SFPENLRHLK NTMETIDWKV FESWMHHWLL FEMSRHSLEQ
200
201
KPTDAPPKVL TKCQEEVSHI PAVHPGSFRP KCDENGNYLP LQCYGSIGYC
250
251
WCVFPNGTEV PNTRSRGHHN CSESLELEDP SSGLGVTKQD LGPVPM    
296
 

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Checksums:
CRC64:27A13F252D5FB91D
MD5:2991837d7224dd528e45e3d8d09b87ab

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
MHC2-interact 103 - 116 3QXD C 87 - 100 Jmol AstexViewer SPICE
F 87 - 100 Jmol AstexViewer SPICE
103 - 117 1A6A C 87 - 101 Jmol AstexViewer SPICE
1MUJ C 87 - 101 Jmol AstexViewer SPICE
103 - 119 3PDO C 103 - 119 Jmol AstexViewer SPICE
104 - 117 3QXA C 88 - 101 Jmol AstexViewer SPICE
105 - 116 3QXA F 89 - 100 Jmol AstexViewer SPICE
106 - 120 3PGC C 106 - 120 Jmol AstexViewer SPICE
F 106 - 120 Jmol AstexViewer SPICE
3PGD C 106 - 120 Jmol AstexViewer SPICE
F 106 - 120 Jmol AstexViewer SPICE
MHCassoc_trimer 136 - 207 1IIE A 120 - 191 Jmol AstexViewer SPICE
B 120 - 191 Jmol AstexViewer SPICE
C 120 - 191 Jmol AstexViewer SPICE
Thyroglobulin_1 210 - 271 1ICF I 194 - 255 Jmol AstexViewer SPICE
J 194 - 255 Jmol AstexViewer SPICE
1L3H A 1 - 62 Jmol AstexViewer SPICE