Summary
This is the summary of UniProt entry HG2A_HUMAN (P04233).
| Description: | HLA class II histocompatibility antigen gamma chain |
| Source organism: |
Homo sapiens (Human) |
| Length: | 296 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| disorder | n/a | 1 | 41 |
| Pfam A | MHC2-interact | 17 | 129 |
| transmembrane | n/a | 48 | 72 |
| disorder | n/a | 83 | 84 |
| disorder | n/a | 89 | 106 |
| disorder | n/a | 108 | 110 |
| disorder | n/a | 121 | 122 |
| disorder | n/a | 125 | 134 |
| Pfam A | MHCassoc_trimer | 136 | 207 |
| disorder | n/a | 200 | 212 |
| Pfam A | Thyroglobulin_1 | 207 | 271 |
| disorder | n/a | 214 | 216 |
| disorder | n/a | 224 | 226 |
| disorder | n/a | 263 | 274 |
| disorder | n/a | 282 | 296 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession P04233. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MHRRRSRSCR EDQKPVMDDQ RDLISNNEQL PMLGRRPGAP ESKCSRGALY
50 51
TGFSILVTLL LAGQATTAYF LYQQQGRLDK LTVTSQNLQL ENLRMKLPKP
100 101
PKPVSKMRMA TPLLMQALPM GALPQGPMQN ATKYGNMTED HVMHLLQNAD
150 151
PLKVYPPLKG SFPENLRHLK NTMETIDWKV FESWMHHWLL FEMSRHSLEQ
200 201
KPTDAPPKVL TKCQEEVSHI PAVHPGSFRP KCDENGNYLP LQCYGSIGYC
250 251
WCVFPNGTEV PNTRSRGHHN CSESLELEDP SSGLGVTKQD LGPVPM
296
Show the unformatted sequence. |
| Checksums: |
CRC64:27A13F252D5FB91D
MD5:2991837d7224dd528e45e3d8d09b87ab
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| MHC2-interact | 103 - 116 | 3QXD | C | 87 - 100 | Jmol AstexViewer SPICE |
| F | 87 - 100 | Jmol AstexViewer SPICE | |||
| 103 - 117 | 1A6A | C | 87 - 101 | Jmol AstexViewer SPICE | |
| 1MUJ | C | 87 - 101 | Jmol AstexViewer SPICE | ||
| 103 - 119 | 3PDO | C | 103 - 119 | Jmol AstexViewer SPICE | |
| 104 - 117 | 3QXA | C | 88 - 101 | Jmol AstexViewer SPICE | |
| 105 - 116 | 3QXA | F | 89 - 100 | Jmol AstexViewer SPICE | |
| 106 - 120 | 3PGC | C | 106 - 120 | Jmol AstexViewer SPICE | |
| F | 106 - 120 | Jmol AstexViewer SPICE | |||
| 3PGD | C | 106 - 120 | Jmol AstexViewer SPICE | ||
| F | 106 - 120 | Jmol AstexViewer SPICE | |||
| MHCassoc_trimer | 136 - 207 | 1IIE | A | 120 - 191 | Jmol AstexViewer SPICE |
| B | 120 - 191 | Jmol AstexViewer SPICE | |||
| C | 120 - 191 | Jmol AstexViewer SPICE | |||
| Thyroglobulin_1 | 210 - 271 | 1ICF | I | 194 - 255 | Jmol AstexViewer SPICE |
| J | 194 - 255 | Jmol AstexViewer SPICE | |||
| 1L3H | A | 1 - 62 | Jmol AstexViewer SPICE |