Summary
This is the summary of UniProt entry NTRK1_HUMAN (P04629).
| Description: | High affinity nerve growth factor receptor EC=2.7.10.1 |
| Source organism: |
Homo sapiens (Human) |
| Length: | 796 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| sig_p | n/a | 1 | 33 |
| low_complexity | n/a | 29 | 42 |
| low_complexity | n/a | 82 | 96 |
| disorder | n/a | 178 | 179 |
| Pfam A | Ig_2 | 194 | 284 |
| disorder | n/a | 394 | 411 |
| transmembrane | n/a | 416 | 439 |
| disorder | n/a | 482 | 484 |
| Pfam A | Pkinase_Tyr | 510 | 781 |
| low_complexity | n/a | 617 | 631 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession P04629. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MLRGGRRGQL GWHSWAAGPG SLLAWLILAS AGAAPCPDAC CPHGSSGLRC
50 51
TRDGALDSLH HLPGAENLTE LYIENQQHLQ HLELRDLRGL GELRNLTIVK
100 101
SGLRFVAPDA FHFTPRLSRL NLSFNALESL SWKTVQGLSL QELVLSGNPL
150 151
HCSCALRWLQ RWEEEGLGGV PEQKLQCHGQ GPLAHMPNAS CGVPTLKVQV
200 201
PNASVDVGDD VLLRCQVEGR GLEQAGWILT ELEQSATVMK SGGLPSLGLT
250 251
LANVTSDLNR KNVTCWAEND VGRAEVSVQV NVSFPASVQL HTAVEMHHWC
300 301
IPFSVDGQPA PSLRWLFNGS VLNETSFIFT EFLEPAANET VRHGCLRLNQ
350 351
PTHVNNGNYT LLAANPFGQA SASIMAAFMD NPFEFNPEDP IPVSFSPVDT
400 401
NSTSGDPVEK KDETPFGVSV AVGLAVFACL FLSTLLLVLN KCGRRNKFGI
450 451
NRPAVLAPED GLAMSLHFMT LGGSSLSPTE GKGSGLQGHI IENPQYFSDA
500 501
CVHHIKRRDI VLKWELGEGA FGKVFLAECH NLLPEQDKML VAVKALKEAS
550 551
ESARQDFQRE AELLTMLQHQ HIVRFFGVCT EGRPLLMVFE YMRHGDLNRF
600 601
LRSHGPDAKL LAGGEDVAPG PLGLGQLLAV ASQVAAGMVY LAGLHFVHRD
650 651
LATRNCLVGQ GLVVKIGDFG MSRDIYSTDY YRVGGRTMLP IRWMPPESIL
700 701
YRKFTTESDV WSFGVVLWEI FTYGKQPWYQ LSNTEAIDCI TQGRELERPR
750 751
ACPPEVYAIM RGCWQREPQQ RHSIKDVHAR LQALAQAPPV YLDVLG
796
Show the unformatted sequence. |
| Checksums: |
CRC64:6C15C721E336B601
MD5:4a99a7644710818e8173e9bbb71bee17
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| Ig_2 | 194 - 284 | 2IFG | A | 194 - 284 | Jmol AstexViewer SPICE |
| B | 194 - 284 | Jmol AstexViewer SPICE | |||
| 278 - 284 | 1WWA | Y | 278 - 284 | Jmol AstexViewer SPICE | |
| 282 - 284 | 1WWA | X | 282 - 284 | Jmol AstexViewer SPICE | |
| 1WWW | X | 282 - 284 | Jmol AstexViewer SPICE | ||
| Y | 282 - 284 | Jmol AstexViewer SPICE |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.