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13  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: AMY1_HUMAN (P04745)

Summary

This is the summary of UniProt entry AMY1_HUMAN (P04745).

Description: Alpha-amylase 1 EC=3.2.1.1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 511 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
sig_p n/a 1 15
Pfam A Alpha-amylase 36 351
disorder n/a 373 375
disorder n/a 378 381
disorder n/a 383 386
Pfam A Alpha-amylase_C 421 510

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P04745. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MKLFWLLFTI GFCWAQYSSN TQQGRTSIVH LFEWRWVDIA LECERYLAPK
50
51
GFGGVQVSPP NENVAIHNPF RPWWERYQPV SYKLCTRSGN EDEFRNMVTR
100
101
CNNVGVRIYV DAVINHMCGN AVSAGTSSTC GSYFNPGSRD FPAVPYSGWD
150
151
FNDGKCKTGS GDIENYNDAT QVRDCRLSGL LDLALGKDYV RSKIAEYMNH
200
201
LIDIGVAGFR IDASKHMWPG DIKAILDKLH NLNSNWFPEG SKPFIYQEVI
250
251
DLGGEPIKSS DYFGNGRVTE FKYGAKLGTV IRKWNGEKMS YLKNWGEGWG
300
301
FMPSDRALVF VDNHDNQRGH GAGGASILTF WDARLYKMAV GFMLAHPYGF
350
351
TRVMSSYRWP RYFENGKDVN DWVGPPNDNG VTKEVTINPD TTCGNDWVCE
400
401
HRWRQIRNMV NFRNVVDGQP FTNWYDNGSN QVAFGRGNRG FIVFNNDDWT
450
451
FSLTLQTGLP AGTYCDVISG DKINGNCTGI KIYVSDDGKA HFSISNSAED
500
501
PFIAIHAESK L                                          
511
 

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Checksums:
CRC64:7710BCAC83EBE8B2
MD5:2e9ff582f8d1ed489f0c6d5662c4898d

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Alpha-amylase 36 - 351 1C8Q A 21 - 336 Jmol AstexViewer SPICE
1JXJ A 21 - 336 Jmol AstexViewer SPICE
1JXK A 21 - 331 Jmol AstexViewer SPICE
1MFU A 21 - 331 Jmol AstexViewer SPICE
1MFV A 21 - 336 Jmol AstexViewer SPICE
1NM9 A 21 - 336 Jmol AstexViewer SPICE
1Q4N X 21 - 336 Jmol AstexViewer SPICE
1SMD A 21 - 336 Jmol AstexViewer SPICE
1XV8 A 21 - 336 Jmol AstexViewer SPICE
B 21 - 336 Jmol AstexViewer SPICE
1Z32 X 21 - 336 Jmol AstexViewer SPICE
3BLK A 21 - 336 Jmol AstexViewer SPICE
3BLP X 21 - 336 Jmol AstexViewer SPICE
3DHP A 21 - 336 Jmol AstexViewer SPICE
Alpha-amylase_C 421 - 510 1C8Q A 406 - 495 Jmol AstexViewer SPICE
1JXJ A 406 - 495 Jmol AstexViewer SPICE
1JXK A 401 - 490 Jmol AstexViewer SPICE
1MFU A 401 - 490 Jmol AstexViewer SPICE
1MFV A 406 - 495 Jmol AstexViewer SPICE
1NM9 A 406 - 495 Jmol AstexViewer SPICE
1Q4N X 406 - 495 Jmol AstexViewer SPICE
1SMD A 406 - 495 Jmol AstexViewer SPICE
1XV8 A 406 - 495 Jmol AstexViewer SPICE
B 406 - 495 Jmol AstexViewer SPICE
1Z32 X 406 - 495 Jmol AstexViewer SPICE
3BLK A 406 - 495 Jmol AstexViewer SPICE
3BLP X 406 - 495 Jmol AstexViewer SPICE
3DHP A 406 - 495 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.