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38  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: AMYP_HUMAN (P04746)

Summary

This is the summary of UniProt entry AMYP_HUMAN (P04746).

Description: Pancreatic alpha-amylase EC=3.2.1.1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 511 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
sig_p n/a 1 15
Pfam A Alpha-amylase 36 351
disorder n/a 368 370
disorder n/a 374 375
disorder n/a 380 381
disorder n/a 383 385
Pfam A Alpha-amylase_C 421 510

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P04746. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MKFFLLLFTI GFCWAQYSPN TQQGRTSIVH LFEWRWVDIA LECERYLAPK
50
51
GFGGVQVSPP NENVAIYNPF RPWWERYQPV SYKLCTRSGN EDEFRNMVTR
100
101
CNNVGVRIYV DAVINHMCGN AVSAGTSSTC GSYFNPGSRD FPAVPYSGWD
150
151
FNDGKCKTGS GDIENYNDAT QVRDCRLTGL LDLALEKDYV RSKIAEYMNH
200
201
LIDIGVAGFR LDASKHMWPG DIKAILDKLH NLNSNWFPAG SKPFIYQEVI
250
251
DLGGEPIKSS DYFGNGRVTE FKYGAKLGTV IRKWNGEKMS YLKNWGEGWG
300
301
FVPSDRALVF VDNHDNQRGH GAGGASILTF WDARLYKMAV GFMLAHPYGF
350
351
TRVMSSYRWP RQFQNGNDVN DWVGPPNNNG VIKEVTINPD TTCGNDWVCE
400
401
HRWRQIRNMV IFRNVVDGQP FTNWYDNGSN QVAFGRGNRG FIVFNNDDWS
450
451
FSLTLQTGLP AGTYCDVISG DKINGNCTGI KIYVSDDGKA HFSISNSAED
500
501
PFIAIHAESK L                                          
511
 

Show the unformatted sequence.

Checksums:
CRC64:A77B1A34EACB3C2A
MD5:d66e983815647cbdf36d9e6f2d6f2ccb

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Alpha-amylase 36 - 351 1B2Y A 21 - 336 Jmol AstexViewer SPICE
1BSI A 21 - 336 Jmol AstexViewer SPICE
1CPU A 21 - 336 Jmol AstexViewer SPICE
1HNY A 21 - 336 Jmol AstexViewer SPICE
1KB3 A 21 - 336 Jmol AstexViewer SPICE
1KBB A 21 - 336 Jmol AstexViewer SPICE
1KBK A 21 - 336 Jmol AstexViewer SPICE
1KGU A 21 - 336 Jmol AstexViewer SPICE
1KGW A 21 - 336 Jmol AstexViewer SPICE
1KGX A 21 - 336 Jmol AstexViewer SPICE
1U2Y A 21 - 336 Jmol AstexViewer SPICE
1U30 A 21 - 336 Jmol AstexViewer SPICE
1U33 A 21 - 336 Jmol AstexViewer SPICE
1XCW A 21 - 336 Jmol AstexViewer SPICE
1XCX A 21 - 336 Jmol AstexViewer SPICE
1XD0 A 21 - 336 Jmol AstexViewer SPICE
1XD1 A 21 - 336 Jmol AstexViewer SPICE
1XGZ A 21 - 336 Jmol AstexViewer SPICE
1XH0 A 21 - 336 Jmol AstexViewer SPICE
1XH1 A 21 - 336 Jmol AstexViewer SPICE
1XH2 A 21 - 336 Jmol AstexViewer SPICE
2CPU A 21 - 336 Jmol AstexViewer SPICE
2QMK A 21 - 336 Jmol AstexViewer SPICE
2QV4 A 21 - 336 Jmol AstexViewer SPICE
3BAI A 21 - 336 Jmol AstexViewer SPICE
3BAJ A 21 - 336 Jmol AstexViewer SPICE
3BAK A 21 - 336 Jmol AstexViewer SPICE
3BAW A 21 - 336 Jmol AstexViewer SPICE
3BAX A 21 - 336 Jmol AstexViewer SPICE
3BAY A 21 - 336 Jmol AstexViewer SPICE
3CPU A 21 - 336 Jmol AstexViewer SPICE
3IJ7 A 21 - 336 Jmol AstexViewer SPICE
3IJ8 A 21 - 336 Jmol AstexViewer SPICE
3IJ9 A 21 - 336 Jmol AstexViewer SPICE
3OLD A 21 - 336 Jmol AstexViewer SPICE
3OLE A 21 - 336 Jmol AstexViewer SPICE
3OLG A 21 - 336 Jmol AstexViewer SPICE
3OLI A 21 - 336 Jmol AstexViewer SPICE
Alpha-amylase_C 421 - 510 1B2Y A 406 - 495 Jmol AstexViewer SPICE
1BSI A 406 - 495 Jmol AstexViewer SPICE
1CPU A 406 - 495 Jmol AstexViewer SPICE
1HNY A 406 - 495 Jmol AstexViewer SPICE
1KB3 A 406 - 495 Jmol AstexViewer SPICE
1KBB A 406 - 495 Jmol AstexViewer SPICE
1KBK A 406 - 495 Jmol AstexViewer SPICE
1KGU A 406 - 495 Jmol AstexViewer SPICE
1KGW A 406 - 495 Jmol AstexViewer SPICE
1KGX A 406 - 495 Jmol AstexViewer SPICE
1U2Y A 406 - 495 Jmol AstexViewer SPICE
1U30 A 406 - 495 Jmol AstexViewer SPICE
1U33 A 406 - 495 Jmol AstexViewer SPICE
1XCW A 406 - 495 Jmol AstexViewer SPICE
1XCX A 406 - 495 Jmol AstexViewer SPICE
1XD0 A 406 - 495 Jmol AstexViewer SPICE
1XD1 A 406 - 495 Jmol AstexViewer SPICE
1XGZ A 406 - 495 Jmol AstexViewer SPICE
1XH0 A 406 - 495 Jmol AstexViewer SPICE
1XH1 A 406 - 495 Jmol AstexViewer SPICE
1XH2 A 406 - 495 Jmol AstexViewer SPICE
2CPU A 406 - 495 Jmol AstexViewer SPICE
2QMK A 406 - 495 Jmol AstexViewer SPICE
2QV4 A 406 - 495 Jmol AstexViewer SPICE
3BAI A 406 - 495 Jmol AstexViewer SPICE
3BAJ A 406 - 495 Jmol AstexViewer SPICE
3BAK A 406 - 495 Jmol AstexViewer SPICE
3BAW A 406 - 495 Jmol AstexViewer SPICE
3BAX A 406 - 495 Jmol AstexViewer SPICE
3BAY A 406 - 495 Jmol AstexViewer SPICE
3CPU A 406 - 495 Jmol AstexViewer SPICE
3IJ7 A 406 - 495 Jmol AstexViewer SPICE
3IJ8 A 406 - 495 Jmol AstexViewer SPICE
3IJ9 A 406 - 495 Jmol AstexViewer SPICE
3OLD A 406 - 495 Jmol AstexViewer SPICE
3OLE A 406 - 495 Jmol AstexViewer SPICE
3OLG A 406 - 495 Jmol AstexViewer SPICE
3OLI A 406 - 495 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.