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17  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: FYN_HUMAN (P06241)

Summary

This is the summary of UniProt entry FYN_HUMAN (P06241).

Description: Tyrosine-protein kinase Fyn EC=2.7.10.2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 537 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
disorder n/a 14 35
disorder n/a 40 41
low_complexity n/a 73 86
disorder n/a 74 75
Pfam A SH3_1 88 135
Pfam A SH2 149 231
Pfam A Pkinase_Tyr 271 520
disorder n/a 534 537

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P06241. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGCVQCKDKE ATKLTEERDG SLNQSSGYRY GTDPTPQHYP SFGVTSIPNY
50
51
NNFHAAGGQG LTVFGGVNSS SHTGTLRTRG GTGVTLFVAL YDYEARTEDD
100
101
LSFHKGEKFQ ILNSSEGDWW EARSLTTGET GYIPSNYVAP VDSIQAEEWY
150
151
FGKLGRKDAE RQLLSFGNPR GTFLIRESET TKGAYSLSIR DWDDMKGDHV
200
201
KHYKIRKLDN GGYYITTRAQ FETLQQLVQH YSERAAGLCC RLVVPCHKGM
250
251
PRLTDLSVKT KDVWEIPRES LQLIKRLGNG QFGEVWMGTW NGNTKVAIKT
300
301
LKPGTMSPES FLEEAQIMKK LKHDKLVQLY AVVSEEPIYI VTEYMNKGSL
350
351
LDFLKDGEGR ALKLPNLVDM AAQVAAGMAY IERMNYIHRD LRSANILVGN
400
401
GLICKIADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW
450
451
SFGILLTELV TKGRVPYPGM NNREVLEQVE RGYRMPCPQD CPISLHELMI
500
501
HCWKKDPEER PTFEYLQSFL EDYFTATEPQ YQPGENL              
537
 

Show the unformatted sequence.

Checksums:
CRC64:4A1E443A4B5A0977
MD5:a4554222869c00fd751dc364e23f6a4d

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Pkinase_Tyr 271 - 520 2DQ7 X 11 - 260 Jmol AstexViewer SPICE
SH2 149 - 231 1AOT F 7 - 89 Jmol AstexViewer SPICE
1AOU F 7 - 89 Jmol AstexViewer SPICE
1G83 A 149 - 231 Jmol AstexViewer SPICE
B 149 - 231 Jmol AstexViewer SPICE
SH3_1 88 - 135 1A0N B 88 - 145 Jmol AstexViewer SPICE
1AVZ C 88 - 135 Jmol AstexViewer SPICE
1AZG B 88 - 135 Jmol AstexViewer SPICE
1EFN A 88 - 135 Jmol AstexViewer SPICE
C 88 - 135 Jmol AstexViewer SPICE
1FYN A 88 - 135 Jmol AstexViewer SPICE
1G83 A 88 - 135 Jmol AstexViewer SPICE
B 88 - 135 Jmol AstexViewer SPICE
1M27 C 88 - 135 Jmol AstexViewer SPICE
1NYF A 88 - 135 Jmol AstexViewer SPICE
1NYG A 88 - 135 Jmol AstexViewer SPICE
1SHF A 88 - 135 Jmol AstexViewer SPICE
B 88 - 135 Jmol AstexViewer SPICE
1ZBJ A 5 - 52 Jmol AstexViewer SPICE
3H0F A 88 - 135 Jmol AstexViewer SPICE
3H0H A 88 - 135 Jmol AstexViewer SPICE
3H0I A 88 - 135 Jmol AstexViewer SPICE
B 88 - 135 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.