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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: KCRM_HUMAN (P06732)

Summary

This is the summary of UniProt entry KCRM_HUMAN (P06732).

Description: Creatine kinase M-type EC=2.7.3.2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 381 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
disorder n/a 14 19
Pfam A ATP-gua_PtransN 21 100
disorder n/a 21 26
disorder n/a 51 57
disorder n/a 96 98
disorder n/a 100 116
Pfam A ATP-gua_Ptrans 120 367
disorder n/a 139 142
low_complexity n/a 357 369
disorder n/a 372 374
disorder n/a 378 379

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P06732. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MPFGNTHNKF KLNYKPEEEY PDLSKHNNHM AKVLTLELYK KLRDKETPSG
50
51
FTVDDVIQTG VDNPGHPFIM TVGCVAGDEE SYEVFKELFD PIISDRHGGY
100
101
KPTDKHKTDL NHENLKGGDD LDPNYVLSSR VRTGRSIKGY TLPPHCSRGE
150
151
RRAVEKLSVE ALNSLTGEFK GKYYPLKSMT EKEQQQLIDD HFLFDKPVSP
200
201
LLLASGMARD WPDARGIWHN DNKSFLVWVN EEDHLRVISM EKGGNMKEVF
250
251
RRFCVGLQKI EEIFKKAGHP FMWNQHLGYV LTCPSNLGTG LRGGVHVKLA
300
301
HLSKHPKFEE ILTRLRLQKR GTGGVDTAAV GSVFDVSNAD RLGSSEVEQV
350
351
QLVVDGVKLM VEMEKKLEKG QSIDDMIPAQ K                    
381
 

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Checksums:
CRC64:418FEAD0C2E138C8
MD5:56058feb4d9c3f7490332024fe9e2678

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
ATP-gua_Ptrans 120 - 367 1I0E A 120 - 367 Jmol AstexViewer SPICE
B 120 - 367 Jmol AstexViewer SPICE
C 120 - 367 Jmol AstexViewer SPICE
D 120 - 367 Jmol AstexViewer SPICE
ATP-gua_PtransN 21 - 100 1I0E A 21 - 100 Jmol AstexViewer SPICE
B 21 - 100 Jmol AstexViewer SPICE
C 21 - 100 Jmol AstexViewer SPICE
D 21 - 100 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.