Summary
This is the summary of UniProt entry POLG_WNV (P06935).
| Description: | Genome polyprotein EC=3.4.21.91 EC=3.6.1.15 EC=3.6.4.13 EC=2.1.1.56 EC=2.1.1.57 EC=2.7.7.48 |
| Source organism: |
West Nile virus (WNV)
(NCBI taxonomy ID
11082)
View Pfam proteome data. |
| Length: | 3430 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| disorder | n/a | 1 | 15 |
| Pfam A | Flavi_capsid | 6 | 123 |
| transmembrane | n/a | 21 | 38 |
| transmembrane | n/a | 44 | 66 |
| low_complexity | n/a | 46 | 60 |
| disorder | n/a | 95 | 97 |
| transmembrane | n/a | 107 | 126 |
| Pfam A | Flavi_propep | 128 | 214 |
| low_complexity | n/a | 208 | 216 |
| disorder | n/a | 215 | 216 |
| Pfam A | Flavi_M | 216 | 290 |
| transmembrane | n/a | 250 | 269 |
| transmembrane | n/a | 276 | 292 |
| Pfam A | Flavi_glycoprot | 291 | 585 |
| low_complexity | n/a | 405 | 416 |
| disorder | n/a | 522 | 527 |
| Pfam A | Flavi_glycop_C | 587 | 685 |
| disorder | n/a | 609 | 610 |
| low_complexity | n/a | 714 | 725 |
| transmembrane | n/a | 739 | 760 |
| transmembrane | n/a | 767 | 787 |
| Pfam A | Flavi_NS1 | 789 | 1143 |
| disorder | n/a | 922 | 924 |
| disorder | n/a | 932 | 935 |
| disorder | n/a | 1040 | 1052 |
| disorder | n/a | 1078 | 1083 |
| disorder | n/a | 1085 | 1086 |
| transmembrane | n/a | 1144 | 1163 |
| Pfam A | Flavi_NS2A | 1151 | 1370 |
| transmembrane | n/a | 1175 | 1193 |
| transmembrane | n/a | 1213 | 1231 |
| transmembrane | n/a | 1243 | 1260 |
| low_complexity | n/a | 1245 | 1256 |
| transmembrane | n/a | 1280 | 1301 |
| transmembrane | n/a | 1308 | 1326 |
| transmembrane | n/a | 1338 | 1362 |
| Pfam A | Flavi_NS2B | 1374 | 1501 |
| transmembrane | n/a | 1374 | 1392 |
| transmembrane | n/a | 1398 | 1416 |
| transmembrane | n/a | 1473 | 1494 |
| disorder | n/a | 1509 | 1511 |
| Pfam A | Peptidase_S7 | 1517 | 1669 |
| disorder | n/a | 1601 | 1604 |
| disorder | n/a | 1610 | 1615 |
| disorder | n/a | 1628 | 1629 |
| disorder | n/a | 1667 | 1668 |
| disorder | n/a | 1673 | 1681 |
| Pfam A | Flavi_DEAD | 1685 | 1832 |
| disorder | n/a | 1819 | 1820 |
| disorder | n/a | 1825 | 1838 |
| Pfam A | Helicase_C | 1878 | 1967 |
| disorder | n/a | 1956 | 1958 |
| disorder | n/a | 1961 | 1963 |
| disorder | n/a | 1973 | 1976 |
| disorder | n/a | 2022 | 2023 |
| Pfam A | Flavi_NS4A | 2123 | 2267 |
| transmembrane | n/a | 2170 | 2191 |
| low_complexity | n/a | 2195 | 2208 |
| transmembrane | n/a | 2200 | 2218 |
| transmembrane | n/a | 2224 | 2241 |
| low_complexity | n/a | 2227 | 2239 |
| transmembrane | n/a | 2253 | 2270 |
| Pfam A | Flavi_NS4B | 2270 | 2519 |
| transmembrane | n/a | 2309 | 2326 |
| transmembrane | n/a | 2347 | 2370 |
| transmembrane | n/a | 2376 | 2395 |
| low_complexity | n/a | 2376 | 2388 |
| transmembrane | n/a | 2443 | 2462 |
| disorder | n/a | 2564 | 2565 |
| disorder | n/a | 2567 | 2577 |
| Pfam A | FtsJ | 2579 | 2750 |
| disorder | n/a | 2625 | 2634 |
| disorder | n/a | 2777 | 2780 |
| Pfam A | Flavi_NS5 | 2778 | 3426 |
| disorder | n/a | 2790 | 2792 |
| disorder | n/a | 2794 | 2799 |
| low_complexity | n/a | 2860 | 2874 |
| disorder | n/a | 2866 | 2870 |
| disorder | n/a | 2873 | 2874 |
| disorder | n/a | 2876 | 2889 |
| disorder | n/a | 2892 | 2897 |
| disorder | n/a | 3118 | 3120 |
| disorder | n/a | 3159 | 3164 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession P06935. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MSKKPGGPGK NRAVNMLKRG MPRGLSLIGL KRAMLSLIDG KGPIRFVLAL
50 51
LAFFRFTAIA PTRAVLDRWR GVNKQTAMKH LLSFKKELGT LTSAINRRST
100 101
KQKKRGGTAG FTILLGLIAC AGAVTLSNFQ GKVMMTVNAT DVTDVITIPT
150 151
AAGKNLCIVR AMDVGYLCED TITYECPVLA AGNDPEDIDC WCTKSSVYVR
200 201
YGRCTKTRHS RRSRRSLTVQ THGESTLANK KGAWLDSTKA TRYLVKTESW
250 251
ILRNPGYALV AAVIGWMLGS NTMQRVVFAI LLLLVAPAYS FNCLGMSNRD
300 301
FLEGVSGATW VDLVLEGDSC VTIMSKDKPT IDVKMMNMEA ANLADVRSYC
350 351
YLASVSDLST RAACPTMGEA HNEKRADPAF VCKQGVVDRG WGNGCGLFGK
400 401
GSIDTCAKFA CTTKATGWII QKENIKYEVA IFVHGPTTVE SHGKIGATQA
450 451
GRFSITPSAP SYTLKLGEYG EVTVDCEPRS GIDTSAYYVM SVGEKSFLVH
500 501
REWFMDLNLP WSSAGSTTWR NRETLMEFEE PHATKQSVVA LGSQEGALHQ
550 551
ALAGAIPVEF SSNTVKLTSG HLKCRVKMEK LQLKGTTYGV CSKAFKFART
600 601
PADTGHGTVV LELQYTGTDG PCKVPISSVA SLNDLTPVGR LVTVNPFVSV
650 651
ATANSKVLIE LEPPFGDSYI VVGRGEQQIN HHWHKSGSSI GKAFTTTLRG
700 701
AQRLAALGDT AWDFGSVGGV FTSVGKAIHQ VFGGAFRSLF GGMSWITQGL
750 751
LGALLLWMGI NARDRSIAMT FLAVGGVLLF LSVNVHADTG CAIDIGRQEL
800 801
RCGSGVFIHN DVEAWMDRYK FYPETPQGLA KIIQKAHAEG VCGLRSVSRL
850 851
EHQMWEAIKD ELNTLLKENG VDLSVVVEKQ NGMYKAAPKR LAATTEKLEM
900 901
GWKAWGKSII FAPELANNTF VIDGPETEEC PTANRAWNSM EVEDFGFGLT
950 951
STRMFLRIRE TNTTECDSKI IGTAVKNNMA VHSDLSYWIE SGLNDTWKLE
1000 1001
RAVLGEVKSC TWPETHTLWG DGVLESDLII PITLAGPRSN HNRRPGYKTQ
1050 1051
NQGPWDEGRV EIDFDYCPGT TVTISDSCEH RGPAARTTTE SGKLITDWCC
1100 1101
RSCTLPPLRF QTENGCWYGM EIRPTRHDEK TLVQSRVNAY NADMIDPFQL
1150 1151
GLMVVFLATQ EVLRKRWTAK ISIPAIMLAL LVLVFGGITY TDVLRYVILV
1200 1201
GAAFAEANSG GDVVHLALMA TFKIQPVFLV ASFLKARWTN QESILLMLAA
1250 1251
AFFQMAYYDA KNVLSWEVPD VLNSLSVAWM ILRAISFTNT SNVVVPLLAL
1300 1301
LTPGLKCLNL DVYRILLLMV GVGSLIKEKR SSAAKKKGAC LICLALASTG
1350 1351
VFNPMILAAG LMACDPNRKR GWPATEVMTA VGLMFAIVGG LAELDIDSMA
1400 1401
IPMTIAGLMF AAFVISGKST DMWIERTADI TWESDAEITG SSERVDVRLD
1450 1451
DDGNFQLMND PGAPWKIWML RMACLAISAY TPWAILPSVI GFWITLQYTK
1500 1501
RGGVLWDTPS PKEYKKGDTT TGVYRIMTRG LLGSYQAGAG VMVEGVFHTL
1550 1551
WHTTKGAALM SGEGRLDPYW GSVKEDRLCY GGPWKLQHKW NGHDEVQMIV
1600 1601
VEPGKNVKNV QTKPGVFKTP EGEIGAVTLD YPTGTSGSPI VDKNGDVIGL
1650 1651
YGNGVIMPNG SYISAIVQGE RMEEPAPAGF EPEMLRKKQI TVLDLHPGAG
1700 1701
KTRKILPQII KEAINKRLRT AVLAPTRVVA AEMSEALRGL PIRYQTSAVH
1750 1751
REHSGNEIVD VMCHATLTHR LMSPHRVPNY NLFIMDEAHF TDPASIAARG
1800 1801
YIATKVELGE AAAIFMTATP PGTSDPFPES NAPISDMQTE IPDRAWNTGY
1850 1851
EWITEYVGKT VWFVPSVKMG NEIALCLQRA GKKVIQLNRK SYETEYPKCK
1900 1901
NDDWDFVITT DISEMGANFK ASRVIDSRKS VKPTIIEEGD GRVILGEPSA
1950 1951
ITAASAAQRR GRIGRNPSQV GDEYCYGGHT NEDDSNFAHW TEARIMLDNI
2000 2001
NMPNGLVAQL YQPEREKVYT MDGEYRLRGE ERKNFLEFLR TADLPVWLAY
2050 2051
KVAAAGISYH DRKWCFDGPR TNTILEDNNE VEVITKLGER KILRPRWADA
2100 2101
RVYSDHQALK SFKDFASGKR SQIGLVEVLG RMPEHFMVKT WEALDTMYVV
2150 2151
ATAEKGGRAH RMALEELPDA LQTIVLIALL SVMSLGVFFL LMQRKGIGKI
2200 2201
GLGGVILGAA TFFCWMAEVP GTKIAGMLLL SLLLMIVLIP EPEKQRSQTD
2250 2251
NQLAVFLICV LTLVGAVAAN EMGWLDKTKN DIGSLLGHRP EARETTLGVE
2300 2301
SFLLDLRPAT AWSLYAVTTA VLTPLLKHLI TSDYINTSLT SINVQASALF
2350 2351
TLARGFPFVD VGVSALLLAV GCWGQVTLTV TVTAAALLFC HYAYMVPGWQ
2400 2401
AEAMRSAQRR TAAGIMKNVV VDGIVATDVP ELERTTPVMQ KKVGQIILIL
2450 2451
VSMAAVVVNP SVRTVREAGI LTTAAAVTLW ENGASSVWNA TTAIGLCHIM
2500 2501
RGGWLSCLSI MWTLIKNMEK PGLKRGGAKG RTLGEVWKER LNHMTKEEFT
2550 2551
RYRKEAITEV DRSAAKHARR EGNITGGHPV SRGTAKLRWL VERRFLEPVG
2600 2601
KVVDLGCGRG GWCYYMATQK RVQEVKGYTK GGPGHEEPQL VQSYGWNIVT
2650 2651
MKSGVDVFYR PSEASDTLLC DIGESSSSAE VEEHRTVRVL EMVEDWLHRG
2700 2701
PKEFCIKVLC PYMPKVIEKM ETLQRRYGGG LIRNPLSRNS THEMYWVSHA
2750 2751
SGNIVHSVNM TSQVLLGRME KKTWKGPQFE EDVNLGSGTR AVGKPLLNSD
2800 2801
TSKIKNRIER LKKEYSSTWH QDANHPYRTW NYHGSYEVKP TGSASSLVNG
2850 2851
VVRLLSKPWD TITNVTTMAM TDTTPFGQQR VFKEKVDTKA PEPPEGVKYV
2900 2901
LNETTNWLWA FLARDKKPRM CSREEFIGKV NSNAALGAMF EEQNQWKNAR
2950 2951
EAVEDPKFWE MVDEEREAHL RGECNTCIYN MMGKREKKPG EFGKAKGSRA
3000 3001
IWFMWLGARF LEFEALGFLN EDHWLGRKNS GGGVEGLGLQ KLGYILKEVG
3050 3051
TKPGGKVYAD DTAGWDTRIT KADLENEAKV LELLDGEHRR LARSIIELTY
3100 3101
RHKVVKVMRP AADGKTVMDV ISREDQRGSG QVVTYALNTF TNLAVQLVRM
3150 3151
MEGEGVIGPD DVEKLGKGKG PKVRTWLFEN GEERLSRMAV SGDDCVVKPL
3200 3201
DDRFATSLHF LNAMSKVRKD IQEWKPSTGW YDWQQVPFCS NHFTELIMKD
3250 3251
GRTLVVPCRG QDELIGRARI SPGAGWNVRD TACLAKSYAQ MWLLLYFHRR
3300 3301
DLRLMANAIC SAVPANWVPT GRTTWSIHAK GEWMTTEDML AVWNRVWIEE
3350 3351
NEWMEDKTPV ERWSDVPYSG KREDIWCGSL IGTRTRATWA ENIHVAINQV
3400 3401
RSVIGEEKYV DYMSSLRRYE DTIVVEDTVL
3430
Show the unformatted sequence. |
| Checksums: |
CRC64:42D71B7CB12DC45B
MD5:c500693d89d1b6d2bda240a4e4fd5d28
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| Flavi_glycop_C | 587 - 685 | 2P5P | A | 301 - 399 | Jmol AstexViewer SPICE |
| B | 301 - 399 | Jmol AstexViewer SPICE | |||
| C | 301 - 399 | Jmol AstexViewer SPICE | |||
| Flavi_glycoprot | 297 - 583 | 3I50 | E | 7 - 297 | Jmol AstexViewer SPICE |
| Flavi_NS2B | 1419 - 1459 | 2IJO | A | 49 - 89 | Jmol AstexViewer SPICE |
| 1420 - 1458 | 2FP7 | A | 50 - 88 | Jmol AstexViewer SPICE | |
| 1420 - 1459 | 3E90 | C | 50 - 89 | Jmol AstexViewer SPICE | |
| 1420 - 1463 | 2GGV | A | 50 - 93 | Jmol AstexViewer SPICE | |
| 1421 - 1463 | 3E90 | A | 51 - 93 | Jmol AstexViewer SPICE | |
| Peptidase_S7 | 1517 - 1669 | 2GGV | B | 16 - 168 | Jmol AstexViewer SPICE |
| 2IJO | B | 16 - 168 | Jmol AstexViewer SPICE | ||
| 3E90 | B | 16 - 168 | Jmol AstexViewer SPICE | ||
| D | 16 - 168 | Jmol AstexViewer SPICE | |||
| 1520 - 1669 | 2FP7 | B | 19 - 168 | Jmol AstexViewer SPICE |