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16  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: HCK_HUMAN (P08631)

Summary

This is the summary of UniProt entry HCK_HUMAN (P08631).

Description: Tyrosine-protein kinase HCK EC=2.7.10.2
Source organism: Homo sapiens (Human)
Length: 526 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
disorder n/a 1 20
disorder n/a 23 25
disorder n/a 35 36
disorder n/a 43 74
Pfam A SH3_1 84 130
Pfam A SH2 144 226
disorder n/a 181 183
Pfam A Pkinase_Tyr 262 511
disorder n/a 525 526

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P08631. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGGRSSCEDP GCPRDEERAP RMGCMKSKFL QVGGNTFSKT ETSASPHCPV
50
51
YVPDPTSTIK PGPNSHNSNT PGIREAGSED IIVVALYDYE AIHHEDLSFQ
100
101
KGDQMVVLEE SGEWWKARSL ATRKEGYIPS NYVARVDSLE TEEWFFKGIS
150
151
RKDAERQLLA PGNMLGSFMI RDSETTKGSY SLSVRDYDPR QGDTVKHYKI
200
201
RTLDNGGFYI SPRSTFSTLQ ELVDHYKKGN DGLCQKLSVP CMSSKPQKPW
250
251
EKDAWEIPRE SLKLEKKLGA GQFGEVWMAT YNKHTKVAVK TMKPGSMSVE
300
301
AFLAEANVMK TLQHDKLVKL HAVVTKEPIY IITEFMAKGS LLDFLKSDEG
350
351
SKQPLPKLID FSAQIAEGMA FIEQRNYIHR DLRAANILVS ASLVCKIADF
400
401
GLARVIEDNE YTAREGAKFP IKWTAPEAIN FGSFTIKSDV WSFGILLMEI
450
451
VTYGRIPYPG MSNPEVIRAL ERGYRMPRPE NCPEELYNIM MRCWKNRPEE
500
501
RPTFEYIQSV LDDFYTATES QYQQQP                          
526
 

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Checksums:
CRC64:847E877A0A641725
MD5:c699ae0a92fc5cd855420130fb067bab

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Pkinase_Tyr 262 - 511 1AD5 A 267 - 516 Jmol AstexViewer SPICE
B 267 - 516 Jmol AstexViewer SPICE
1QCF A 267 - 516 Jmol AstexViewer SPICE
2C0I A 241 - 490 Jmol AstexViewer SPICE
B 241 - 490 Jmol AstexViewer SPICE
2C0O A 241 - 490 Jmol AstexViewer SPICE
B 241 - 490 Jmol AstexViewer SPICE
2C0T A 241 - 490 Jmol AstexViewer SPICE
B 241 - 490 Jmol AstexViewer SPICE
2HCK A 267 - 516 Jmol AstexViewer SPICE
B 267 - 516 Jmol AstexViewer SPICE
2HK5 A 245 - 494 Jmol AstexViewer SPICE
SH2 144 - 226 1AD5 A 148 - 230 Jmol AstexViewer SPICE
B 148 - 230 Jmol AstexViewer SPICE
1QCF A 148 - 230 Jmol AstexViewer SPICE
2C0I A 123 - 205 Jmol AstexViewer SPICE
B 123 - 205 Jmol AstexViewer SPICE
2C0O A 123 - 205 Jmol AstexViewer SPICE
B 123 - 205 Jmol AstexViewer SPICE
2C0T A 123 - 205 Jmol AstexViewer SPICE
B 123 - 205 Jmol AstexViewer SPICE
2HCK A 148 - 230 Jmol AstexViewer SPICE
B 148 - 230 Jmol AstexViewer SPICE
3HCK A 6 - 88 Jmol AstexViewer SPICE
3NHN A 148 - 230 Jmol AstexViewer SPICE
SH3_1 84 - 130 1AD5 A 87 - 134 Jmol AstexViewer SPICE
B 87 - 134 Jmol AstexViewer SPICE
1QCF A 87 - 134 Jmol AstexViewer SPICE
2C0I A 63 - 109 Jmol AstexViewer SPICE
B 63 - 109 Jmol AstexViewer SPICE
2C0O A 63 - 109 Jmol AstexViewer SPICE
B 63 - 109 Jmol AstexViewer SPICE
2C0T A 63 - 109 Jmol AstexViewer SPICE
B 63 - 109 Jmol AstexViewer SPICE
2HCK A 87 - 134 Jmol AstexViewer SPICE
B 87 - 134 Jmol AstexViewer SPICE
2OI3 A 29 - 75 Jmol AstexViewer SPICE
2OJ2 A 29 - 75 Jmol AstexViewer SPICE
3NHN A 87 - 134 Jmol AstexViewer SPICE
3RBB B 84 - 130 Jmol AstexViewer SPICE
D 84 - 130 Jmol AstexViewer SPICE
3REA B 84 - 130 Jmol AstexViewer SPICE
D 84 - 130 Jmol AstexViewer SPICE
3REB B 84 - 130 Jmol AstexViewer SPICE
D 84 - 130 Jmol AstexViewer SPICE
4HCK A 84 - 130 Jmol AstexViewer SPICE
5HCK A 84 - 130 Jmol AstexViewer SPICE