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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: RPOB_ECOLI (P0A8V2)

Summary

This is the summary of UniProt entry RPOB_ECOLI (P0A8V2).

Description: DNA-directed RNA polymerase subunit beta EC=2.7.7.6
Source organism: Escherichia coli (strain K12) (NCBI taxonomy ID 83333)
View Pfam proteome data.
Length: 1342 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
Pfam A RNA_pol_Rpb2_1 26 509
Pfam A RNA_pol_Rpb2_2 151 276
Pfam A RNA_pol_Rpb2_2 329 454
Pfam A RNA_pol_Rpb2_3 513 582
disorder n/a 517 518
disorder n/a 525 526
disorder n/a 532 533
disorder n/a 543 545
disorder n/a 556 559
Pfam A RNA_pol_Rpb2_45 591 656
disorder n/a 681 682
disorder n/a 694 696
Pfam A RNA_pol_Rpb2_6 715 1264
disorder n/a 849 850
disorder n/a 856 857
disorder n/a 888 889
coiled_coil n/a 936 970
coiled_coil n/a 1004 1035
disorder n/a 1011 1013
disorder n/a 1070 1073
disorder n/a 1078 1082
Pfam A RNA_pol_Rpb2_7 1266 1342
disorder n/a 1305 1307
disorder n/a 1309 1311

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P0A8V2. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MVYSYTEKKR IRKDFGKRPQ VLDVPYLLSI QLDSFQKFIE QDPEGQYGLE
50
51
AAFRSVFPIQ SYSGNSELQY VSYRLGEPVF DVQECQIRGV TYSAPLRVKL
100
101
RLVIYEREAP EGTVKDIKEQ EVYMGEIPLM TDNGTFVING TERVIVSQLH
150
151
RSPGVFFDSD KGKTHSSGKV LYNARIIPYR GSWLDFEFDP KDNLFVRIDR
200
201
RRKLPATIIL RALNYTTEQI LDLFFEKVIF EIRDNKLQME LVPERLRGET
250
251
ASFDIEANGK VYVEKGRRIT ARHIRQLEKD DVKLIEVPVE YIAGKVVAKD
300
301
YIDESTGELI CAANMELSLD LLAKLSQSGH KRIETLFTND LDHGPYISET
350
351
LRVDPTNDRL SALVEIYRMM RPGEPPTREA AESLFENLFF SEDRYDLSAV
400
401
GRMKFNRSLL REEIEGSGIL SKDDIIDVMK KLIDIRNGKG EVDDIDHLGN
450
451
RRIRSVGEMA ENQFRVGLVR VERAVKERLS LGDLDTLMPQ DMINAKPISA
500
501
AVKEFFGSSQ LSQFMDQNNP LSEITHKRRI SALGPGGLTR ERAGFEVRDV
550
551
HPTHYGRVCP IETPEGPNIG LINSLSVYAQ TNEYGFLETP YRKVTDGVVT
600
601
DEIHYLSAIE EGNYVIAQAN SNLDEEGHFV EDLVTCRSKG ESSLFSRDQV
650
651
DYMDVSTQQV VSVGASLIPF LEHDDANRAL MGANMQRQAV PTLRADKPLV
700
701
GTGMERAVAV DSGVTAVAKR GGVVQYVDAS RIVIKVNEDE MYPGEAGIDI
750
751
YNLTKYTRSN QNTCINQMPC VSLGEPVERG DVLADGPSTD LGELALGQNM
800
801
RVAFMPWNGY NFEDSILVSE RVVQEDRFTT IHIQELACVS RDTKLGPEEI
850
851
TADIPNVGEA ALSKLDESGI VYIGAEVTGG DILVGKVTPK GETQLTPEEK
900
901
LLRAIFGEKA SDVKDSSLRV PNGVSGTVID VQVFTRDGVE KDKRALEIEE
950
951
MQLKQAKKDL SEELQILEAG LFSRIRAVLV AGGVEAEKLD KLPRDRWLEL
1000
1001
GLTDEEKQNQ LEQLAEQYDE LKHEFEKKLE AKRRKITQGD DLAPGVLKIV
1050
1051
KVYLAVKRRI QPGDKMAGRH GNKGVISKIN PIEDMPYDEN GTPVDIVLNP
1100
1101
LGVPSRMNIG QILETHLGMA AKGIGDKINA MLKQQQEVAK LREFIQRAYD
1150
1151
LGADVRQKVD LSTFSDEEVM RLAENLRKGM PIATPVFDGA KEAEIKELLK
1200
1201
LGDLPTSGQI RLYDGRTGEQ FERPVTVGYM YMLKLNHLVD DKMHARSTGS
1250
1251
YSLVTQQPLG GKAQFGGQRF GEMEVWALEA YGAAYTLQEM LTVKSDDVNG
1300
1301
RTKMYKNIVD GNHQMEPGMP ESFNVLLKEI RSLGINIELE DE        
1342
 

Show the unformatted sequence.

Checksums:
CRC64:F9E95344C54AB118
MD5:5a6db54270d33f1e4bfa723559a235e2

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
RNA_pol_Rpb2_1 152 - 443 3LTI A 152 - 443 Jmol AstexViewer SPICE
26 - 509 3IYD C 26 - 509 Jmol AstexViewer SPICE
3LU0 C 26 - 509 Jmol AstexViewer SPICE
RNA_pol_Rpb2_2 151 - 228 3IYD C 151 - 228 Jmol AstexViewer SPICE
151 - 276 3LU0 C 151 - 276 Jmol AstexViewer SPICE
152 - 276 3LTI A 152 - 276 Jmol AstexViewer SPICE
329 - 443 3LTI A 329 - 443 Jmol AstexViewer SPICE
329 - 454 3IYD C 329 - 454 Jmol AstexViewer SPICE
3LU0 C 329 - 454 Jmol AstexViewer SPICE
RNA_pol_Rpb2_3 513 - 582 3IYD C 513 - 582 Jmol AstexViewer SPICE
3LU0 C 513 - 582 Jmol AstexViewer SPICE
RNA_pol_Rpb2_45 591 - 656 3IYD C 591 - 656 Jmol AstexViewer SPICE
3LU0 C 591 - 656 Jmol AstexViewer SPICE
RNA_pol_Rpb2_6 715 - 1264 3IYD C 715 - 1264 Jmol AstexViewer SPICE
3LU0 C 715 - 1264 Jmol AstexViewer SPICE
831 - 1057 3TBI B 831 - 1057 Jmol AstexViewer SPICE
RNA_pol_Rpb2_7 1266 - 1342 3IYD C 1266 - 1342 Jmol AstexViewer SPICE
3LU0 C 1266 - 1342 Jmol AstexViewer SPICE