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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: MSCS_ECOLI (P0C0S1)

Summary

This is the summary of UniProt entry MSCS_ECOLI (P0C0S1).

Description: Small-conductance mechanosensitive channel
Source organism: Escherichia coli (strain K12) (NCBI taxonomy ID 83333)
View Pfam proteome data.
Length: 286 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
Pfam A TM_helix 14 66
transmembrane n/a 24 45
low_complexity n/a 28 45
transmembrane n/a 65 85
Pfam A MS_channel 70 268
low_complexity n/a 94 116
transmembrane n/a 97 125

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P0C0S1. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MEDLNVVDSI NGAGSWLVAN QALLLSYAVN IVAALAIIIV GLIIARMISN
50
51
AVNRLMISRK IDATVADFLS ALVRYGIIAF TLIAALGRVG VQTASVIAVL
100
101
GAAGLAVGLA LQGSLSNLAA GVLLVMFRPF RAGEYVDLGG VAGTVLSVQI
150
151
FSTTMRTADG KIIVIPNGKI IAGNIINFSR EPVRRNEFII GVAYDSDIDQ
200
201
VKQILTNIIQ SEDRILKDRE MTVRLNELGA SSINFVVRVW SNSGDLQNVY
250
251
WDVLERIKRE FDAAGISFPY PQMDVNFKRV KEDKAA               
286
 

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Checksums:
CRC64:FF00AD64F795E9FE
MD5:3f5066a57f5874d23b5e7683e1774555

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
MS_channel 70 - 268 2OAU A 70 - 268 Jmol AstexViewer SPICE
B 70 - 268 Jmol AstexViewer SPICE
C 70 - 268 Jmol AstexViewer SPICE
D 70 - 268 Jmol AstexViewer SPICE
E 70 - 268 Jmol AstexViewer SPICE
F 70 - 268 Jmol AstexViewer SPICE
G 70 - 268 Jmol AstexViewer SPICE
TM_helix 27 - 66 2OAU A 27 - 66 Jmol AstexViewer SPICE
B 27 - 66 Jmol AstexViewer SPICE
C 27 - 66 Jmol AstexViewer SPICE
D 27 - 66 Jmol AstexViewer SPICE
E 27 - 66 Jmol AstexViewer SPICE
F 27 - 66 Jmol AstexViewer SPICE
G 27 - 66 Jmol AstexViewer SPICE