Summary
This is the summary of UniProt entry BCR_HUMAN (P11274).
| Description: | Breakpoint cluster region protein EC=2.7.11.1 |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
View Pfam proteome data. |
| Length: | 1271 amino acids |
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
| Source | Domain | Start | End |
|---|---|---|---|
| Pfam A | Bcr-Abl_Oligo | 1 | 79 |
| disorder | n/a | 9 | 33 |
| coiled_coil | n/a | 28 | 55 |
| disorder | n/a | 36 | 46 |
| disorder | n/a | 70 | 71 |
| disorder | n/a | 73 | 185 |
| low_complexity | n/a | 87 | 121 |
| low_complexity | n/a | 123 | 138 |
| disorder | n/a | 187 | 248 |
| disorder | n/a | 251 | 316 |
| disorder | n/a | 322 | 395 |
| low_complexity | n/a | 340 | 356 |
| low_complexity | n/a | 369 | 387 |
| disorder | n/a | 399 | 401 |
| disorder | n/a | 406 | 475 |
| low_complexity | n/a | 459 | 468 |
| disorder | n/a | 477 | 480 |
| Pfam A | RhoGEF | 502 | 690 |
| low_complexity | n/a | 519 | 531 |
| disorder | n/a | 622 | 635 |
| disorder | n/a | 695 | 703 |
| Pfam A | PH | 704 | 866 |
| coiled_coil | n/a | 784 | 804 |
| disorder | n/a | 800 | 806 |
| disorder | n/a | 809 | 812 |
| low_complexity | n/a | 812 | 829 |
| Pfam A | C2 | 913 | 1000 |
| disorder | n/a | 991 | 998 |
| Pfam A | RhoGAP | 1068 | 1220 |
| transmembrane | n/a | 1164 | 1183 |
| low_complexity | n/a | 1165 | 1186 |
| disorder | n/a | 1217 | 1225 |
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Sequence annotations
This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession P11274. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MVDPVGFAEA WKAQFPDSEP PRMELRSVGD IEQELERCKA SIRRLEQEVN
50 51
QERFRMIYLQ TLLAKEKKSY DRQRWGFRRA AQAPDGASEP RASASRPQPA
100 101
PADGADPPPA EEPEARPDGE GSPGKARPGT ARRPGAAASG ERDDRGPPAS
150 151
VAALRSNFER IRKGHGQPGA DAEKPFYVNV EFHHERGLVK VNDKEVSDRI
200 201
SSLGSQAMQM ERKKSQHGAG SSVGDASRPP YRGRSSESSC GVDGDYEDAE
250 251
LNPRFLKDNL IDANGGSRPP WPPLEYQPYQ SIYVGGMMEG EGKGPLLRSQ
300 301
STSEQEKRLT WPRRSYSPRS FEDCGGGYTP DCSSNENLTS SEEDFSSGQS
350 351
SRVSPSPTTY RMFRDKSRSP SQNSQQSFDS SSPPTPQCHK RHRHCPVVVS
400 401
EATIVGVRKT GQIWPNDGEG AFHGDADGSF GTPPGYGCAA DRAEEQRRHQ
450 451
DGLPYIDDSP SSSPHLSSKG RGSRDALVSG ALESTKASEL DLEKGLEMRK
500 501
WVLSGILASE ETYLSHLEAL LLPMKPLKAA ATTSQPVLTS QQIETIFFKV
550 551
PELYEIHKEF YDGLFPRVQQ WSHQQRVGDL FQKLASQLGV YRAFVDNYGV
600 601
AMEMAEKCCQ ANAQFAEISE NLRARSNKDA KDPTTKNSLE TLLYKPVDRV
650 651
TRSTLVLHDL LKHTPASHPD HPLLQDALRI SQNFLSSINE EITPRRQSMT
700 701
VKKGEHRQLL KDSFMVELVE GARKLRHVFL FTDLLLCTKL KKQSGGKTQQ
750 751
YDCKWYIPLT DLSFQMVDEL EAVPNIPLVP DEELDALKIK ISQIKNDIQR
800 801
EKRANKGSKA TERLKKKLSE QESLLLLMSP SMAFRVHSRN GKSYTFLISS
850 851
DYERAEWREN IREQQKKCFR SFSLTSVELQ MLTNSCVKLQ TVHSIPLTIN
900 901
KEDDESPGLY GFLNVIVHSA TGFKQSSNLY CTLEVDSFGY FVNKAKTRVY
950 951
RDTAEPNWNE EFEIELEGSQ TLRILCYEKC YNKTKIPKED GESTDRLMGK
1000 1001
GQVQLDPQAL QDRDWQRTVI AMNGIEVKLS VKFNSREFSL KRMPSRKQTG
1050 1051
VFGVKIAVVT KRERSKVPYI VRQCVEEIER RGMEEVGIYR VSGVATDIQA
1100 1101
LKAAFDVNNK DVSVMMSEMD VNAIAGTLKL YFRELPEPLF TDEFYPNFAE
1150 1151
GIALSDPVAK ESCMLNLLLS LPEANLLTFL FLLDHLKRVA EKEAVNKMSL
1200 1201
HNLATVFGPT LLRPSEKESK LPANPSQPIT MTDSWSLEVM SQVQVLLYFL
1250 1251
QLEAIPAPDS KRQSILFSTE V
1271
Show the unformatted sequence. |
| Checksums: |
CRC64:4BF66FA1E9D205FE
MD5:e57381f4e6922f554f0236fddba15597
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| Bcr-Abl_Oligo | 1 - 72 | 1K1F | A | 1 - 72 | Jmol AstexViewer SPICE |
| B | 1 - 72 | Jmol AstexViewer SPICE | |||
| C | 1 - 72 | Jmol AstexViewer SPICE | |||
| D | 1 - 72 | Jmol AstexViewer SPICE | |||
| E | 1 - 72 | Jmol AstexViewer SPICE | |||
| F | 1 - 72 | Jmol AstexViewer SPICE | |||
| G | 1 - 72 | Jmol AstexViewer SPICE | |||
| H | 1 - 72 | Jmol AstexViewer SPICE |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.