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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: BCR_HUMAN (P11274)

Summary

This is the summary of UniProt entry BCR_HUMAN (P11274).

Description: Breakpoint cluster region protein EC=2.7.11.1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 1271 amino acids

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Source Domain Start End
Pfam A Bcr-Abl_Oligo 1 79
disorder n/a 9 33
coiled_coil n/a 28 55
disorder n/a 36 46
disorder n/a 70 71
disorder n/a 73 185
low_complexity n/a 87 121
low_complexity n/a 123 138
disorder n/a 187 248
disorder n/a 251 316
disorder n/a 322 395
low_complexity n/a 340 356
low_complexity n/a 369 387
disorder n/a 399 401
disorder n/a 406 475
low_complexity n/a 459 468
disorder n/a 477 480
Pfam A RhoGEF 502 690
low_complexity n/a 519 531
disorder n/a 622 635
disorder n/a 695 703
Pfam A PH 704 866
coiled_coil n/a 784 804
disorder n/a 800 806
disorder n/a 809 812
low_complexity n/a 812 829
Pfam A C2 913 1000
disorder n/a 991 998
Pfam A RhoGAP 1068 1220
transmembrane n/a 1164 1183
low_complexity n/a 1165 1186
disorder n/a 1217 1225

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Sequence annotations

This section shows a graphical representation of this sequence, with Pfam domains shown in the standard Pfam format. Under the Pfam domain image we show various tracks, illustrating features on this sequence that we found in other databases. You can choose which databases to include using the drop-down panel under the image. More...

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P11274. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MVDPVGFAEA WKAQFPDSEP PRMELRSVGD IEQELERCKA SIRRLEQEVN
50
51
QERFRMIYLQ TLLAKEKKSY DRQRWGFRRA AQAPDGASEP RASASRPQPA
100
101
PADGADPPPA EEPEARPDGE GSPGKARPGT ARRPGAAASG ERDDRGPPAS
150
151
VAALRSNFER IRKGHGQPGA DAEKPFYVNV EFHHERGLVK VNDKEVSDRI
200
201
SSLGSQAMQM ERKKSQHGAG SSVGDASRPP YRGRSSESSC GVDGDYEDAE
250
251
LNPRFLKDNL IDANGGSRPP WPPLEYQPYQ SIYVGGMMEG EGKGPLLRSQ
300
301
STSEQEKRLT WPRRSYSPRS FEDCGGGYTP DCSSNENLTS SEEDFSSGQS
350
351
SRVSPSPTTY RMFRDKSRSP SQNSQQSFDS SSPPTPQCHK RHRHCPVVVS
400
401
EATIVGVRKT GQIWPNDGEG AFHGDADGSF GTPPGYGCAA DRAEEQRRHQ
450
451
DGLPYIDDSP SSSPHLSSKG RGSRDALVSG ALESTKASEL DLEKGLEMRK
500
501
WVLSGILASE ETYLSHLEAL LLPMKPLKAA ATTSQPVLTS QQIETIFFKV
550
551
PELYEIHKEF YDGLFPRVQQ WSHQQRVGDL FQKLASQLGV YRAFVDNYGV
600
601
AMEMAEKCCQ ANAQFAEISE NLRARSNKDA KDPTTKNSLE TLLYKPVDRV
650
651
TRSTLVLHDL LKHTPASHPD HPLLQDALRI SQNFLSSINE EITPRRQSMT
700
701
VKKGEHRQLL KDSFMVELVE GARKLRHVFL FTDLLLCTKL KKQSGGKTQQ
750
751
YDCKWYIPLT DLSFQMVDEL EAVPNIPLVP DEELDALKIK ISQIKNDIQR
800
801
EKRANKGSKA TERLKKKLSE QESLLLLMSP SMAFRVHSRN GKSYTFLISS
850
851
DYERAEWREN IREQQKKCFR SFSLTSVELQ MLTNSCVKLQ TVHSIPLTIN
900
901
KEDDESPGLY GFLNVIVHSA TGFKQSSNLY CTLEVDSFGY FVNKAKTRVY
950
951
RDTAEPNWNE EFEIELEGSQ TLRILCYEKC YNKTKIPKED GESTDRLMGK
1000
1001
GQVQLDPQAL QDRDWQRTVI AMNGIEVKLS VKFNSREFSL KRMPSRKQTG
1050
1051
VFGVKIAVVT KRERSKVPYI VRQCVEEIER RGMEEVGIYR VSGVATDIQA
1100
1101
LKAAFDVNNK DVSVMMSEMD VNAIAGTLKL YFRELPEPLF TDEFYPNFAE
1150
1151
GIALSDPVAK ESCMLNLLLS LPEANLLTFL FLLDHLKRVA EKEAVNKMSL
1200
1201
HNLATVFGPT LLRPSEKESK LPANPSQPIT MTDSWSLEVM SQVQVLLYFL
1250
1251
QLEAIPAPDS KRQSILFSTE V                               
1271
 

Show the unformatted sequence.

Checksums:
CRC64:4BF66FA1E9D205FE
MD5:e57381f4e6922f554f0236fddba15597

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Bcr-Abl_Oligo 1 - 72 1K1F A 1 - 72 Jmol AstexViewer SPICE
B 1 - 72 Jmol AstexViewer SPICE
C 1 - 72 Jmol AstexViewer SPICE
D 1 - 72 Jmol AstexViewer SPICE
E 1 - 72 Jmol AstexViewer SPICE
F 1 - 72 Jmol AstexViewer SPICE
G 1 - 72 Jmol AstexViewer SPICE
H 1 - 72 Jmol AstexViewer SPICE

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.